Tan Lab | DSigDB

Gene Set: D4 : CTD - Naloxone

Collection

D4 : CTD

Chemical Name

Naloxone ( From PubChem : NALOXONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Not	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
327.374 g/mol	2	5	1.2393	True

Structure

InChI

InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

InChIKey

UZHSEJADLWPNLE-GRGSLBFTSA-N

Links

Gene (25 / 55)

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Source	Type	Unit	Gene	PMID	Other
CTD	decreases(secretion)		AVP		D009270
CTD	decreases(reaction)		BAX		D009270
CTD	increases(expression)		BAX		D009270
CTD	decreases(expression)		BCL2		D009270
CTD	decreases(reaction)		BCL2		D009270
CTD	decreases(reaction)		CCL2		D009270
CTD	increases(expression)		CCL2		D009270
CTD	decreases(expression)		CCL5		D009270
CTD	decreases(reaction)		CCL5		D009270
CTD	affects(binding)		CES1		D009270
CTD	increases(metabolic processing)		CES1		D009270
CTD	affects(binding)		CES1		D009270
CTD	decreases(reaction)		DDB2		D009270
CTD	increases(expression)		DDB2		D009270
CTD	decreases(reaction)		FGF2		D009270
CTD	decreases(secretion)		FGF2		D009270
CTD	increases(response to substance)		IL1B		D009270
CTD	decreases(reaction)		IL2		D009270
CTD	decreases(response to substance)		IL2		D009270
CTD	decreases(reaction)		IL6		D009270
CTD	increases(expression)		IL6		D009270
CTD	decreases(reaction)		KLF7		D009270
CTD	increases(expression)		KLF7		D009270
CTD	affects(expression)		LHB		D009270
CTD	increases(expression)		LHB		D009270
CTD	increases(activity)		MAPK1		D009270
CTD	increases(phosphorylation)		MAPK1		D009270
CTD	increases(reaction)		MAPK1		D009270
CTD	increases(activity)		MAPK3		D009270
CTD	increases(phosphorylation)		MAPK3		D009270
CTD	increases(reaction)		MAPK3		D009270
CTD	decreases(expression)		NPPA		D009270
CTD	affects(binding)		OPRM1		D009270
CTD	affects(cotreatment)		OPRM1		D009270
CTD	decreases(activity)		OPRM1		D009270
CTD	increases(expression)		OPRM1		D009270
CTD	increases(expression)		POMC		D009270
CTD	increases(response to substance)		POMC		D009270
CTD	affects(binding)		POMC		D009270
CTD	increases(activity)		POMC		D009270
CTD	increases(expression)		POMC		D009270
CTD	affects(expression)		PRL		D009270
CTD	increases(activity)		REN		D009270
CTD	affects(binding)		TLR4		D009270
CTD	affects(reaction)		TLR4		D009270
CTD	decreases(reaction)		TNF		D009270
CTD	increases(expression)		TNF		D009270
CTD	decreases(reaction)		TP53		D009270
CTD	increases(expression)		TP53		D009270
CTD	decreases(reaction)		TP53		D009270
CTD	increases(expression)		TP53		D009270
CTD	increases(phosphorylation)		TP53		D009270
CTD	affects(metabolic processing)		UGT2B7		D009270
ChEMBL	Inhibition	-	OPRD1	-	Target : CHEMBL236
ChEMBL	Activity	-	OPRM1	-	Target : CHEMBL233

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