Tan Lab | DSigDB

Gene Set: D4 : CTD - Mitotane

Collection

D4 : CTD

Chemical Name

Mitotane ( From PubChem : MITOTANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
320.041 g/mol	0	0	5.929	False(3/4)

Structure

InChI

InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H/t13-/m1/s1

InChIKey

JWBOIMRXGHLCPP-CYBMUJFWSA-N

Links

Gene (47 / 101)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB1		D008939
CTD	increases(export)			ABCB1		D008939
CTD	decreases(activity)			ABCB1		D008939
CTD	increases(expression)			ALDH1L2		D008939
CTD	affects(binding)			AR		D008939
CTD	decreases(activity)			AR		D008939
CTD	affects(binding)			AR		D008939
CTD	decreases(reaction)			AR		D008939
CTD	affects(cotreatment)			BAX		D008939
CTD	decreases(expression)			BAX		D008939
CTD	affects(cotreatment)			BCL2		D008939
CTD	decreases(expression)			BCL2		D008939
CTD	increases(activity)			CASP3		D008939
CTD	increases(activity)			CASP7		D008939
CTD	increases(expression)			CCNB1		D008939
CTD	increases(localization)			CCNB1		D008939
CTD	decreases(expression)			COX2		D008939
CTD	decreases(expression)			COX4I1		D008939
CTD	increases(activity)			CREB1		D008939
CTD	increases(activity)			CREBBP		D008939
CTD	decreases(reaction)			CYP11A1		D008939
CTD	increases(expression)			CYP11A1		D008939
CTD	decreases(activity)			CYP11A1		D008939
CTD	decreases(expression)			CYP11A1		D008939
CTD	decreases(expression)			CYP11A1		D008939
CTD	affects(reaction)			CYP11B1		D008939
CTD	increases(expression)			CYP11B1		D008939
CTD	decreases(expression)			CYP11B1		D008939
CTD	increases(expression)			CYP11B1		D008939
CTD	decreases(expression)			CYP11B2		D008939
CTD	decreases(reaction)			CYP17A1		D008939
CTD	increases(expression)			CYP17A1		D008939
CTD	decreases(expression)			CYP17A1		D008939
CTD	decreases(reaction)			CYP21A2		D008939
CTD	increases(expression)			CYP21A2		D008939
CTD	decreases(expression)			CYP21A2		D008939
CTD	affects(abundance)			CYP2B6		D008939
CTD	increases(expression)			CYP3A4		D008939
CTD	increases(reaction)			CYP3A4		D008939
CTD	increases(activity)			CYP3A4		D008939
CTD	increases(activity)			ELK1		D008939
CTD	increases(expression)			ESR1		D008939
CTD	increases(reaction)			ESR1		D008939
CTD	affects(binding)			ESR1		D008939
CTD	affects(binding)			ESR1		D008939
CTD	decreases(reaction)			ESR1		D008939
CTD	increases(expression)			GDF15		D008939
CTD	decreases(reaction)			GSTP1		D008939
CTD	increases(metabolic processing)			GSTP1		D008939
CTD	decreases(expression)			HSD3B1		D008939
CTD	decreases(reaction)			HSD3B2		D008939
CTD	increases(expression)			HSD3B2		D008939
CTD	decreases(expression)			HSD3B2		D008939
CTD	increases(response to substance)			IFNB1		D008939
CTD	decreases(secretion)			IFNB1		D008939
CTD	increases(reaction)			IFNB1		D008939
CTD	affects(binding)			NCOA1		D008939
CTD	increases(reaction)			NCOA1		D008939
CTD	increases(activity)			NOTCH1		D008939
CTD	affects(binding)			NR1I2		D008939
CTD	increases(reaction)			NR1I2		D008939
CTD	increases(expression)			NR1I2		D008939
CTD	affects(binding)			PGR		D008939
CTD	decreases(reaction)			PGR		D008939
CTD	decreases(expression)			PRKAR1A		D008939
CTD	increases(expression)			PTGS2		D008939
CTD	increases(expression)			RRM1		D008939
CTD	decreases(response to substance)			RRM1		D008939
CTD	increases(expression)			SERPINA6		D008939
CTD	increases(reaction)			SERPINA6		D008939
CTD	increases(expression)			SERPINE2		D008939
CTD	increases(expression)			SHBG		D008939
CTD	increases(reaction)			SHBG		D008939
CTD	decreases(reaction)			STAR		D008939
CTD	increases(expression)			STAR		D008939
CTD	decreases(expression)			STAR		D008939
CTD	decreases(expression)			STAR		D008939
CTD	decreases(expression)			TGFB1		D008939
CTD	affects(cotreatment)			TP53		D008939
CTD	decreases(expression)			TP53		D008939
CTD	increases(expression)			TRIB3		D008939
PubChem	None	uM		ARNT	-	GI(Protien) :
PubChem	Potency	uM	28.184	ATM	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.001	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.555	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.696	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.413	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.804	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.972	ESR1	-	GI(Protien) :
PubChem	Potency	uM	5.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	5.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	31.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	31.623	KCNH2		GI(Protien) :
PubChem	None	uM		KCNK3	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	31.623	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.539	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		TACC3	-	GI(Protien) :
ChEMBL	Potency	nM	28183.800	ATM	-	Target : CHEMBL3797

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