DSigDB

Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - Methylprednisolone

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Collection	D4 : CTD
Chemical Name	Methylprednisolone ( From PubChem : METHYLPREDNISOLONE )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Approved Approved Not Approved Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 374.471 g/mol 3 5 1.8036 True
Structure
InChI	InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChIKey	VHRSUDSXCMQTMA-PJHHCJLFSA-N
Links
Gene (20 / 59) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD affects(cotreatment) ABCB1 D008775 CTD affects(response to substance) ABCB1 D008775 CTD increases(secretion) ABCB1 D008775 CTD increases(response to substance) ABCB1 D008775 CTD decreases(reaction) ABCB1 D008775 CTD increases(expression) ABCB1 D008775 CTD increases(expression) ABCB1 D008775 CTD affects(transport) ABCG2 D008775 CTD decreases(reaction) ABCG2 D008775 CTD affects(cotreatment) CXCL8 D008775 CTD decreases(expression) CXCL8 D008775 CTD decreases(expression) CYP3A4 D008775 CTD increases(activity) CYP3A4 D008775 CTD increases(expression) F8 D008775 CTD affects(binding) FCER2 D008775 CTD decreases(reaction) FCER2 D008775 CTD increases(reaction) FCER2 D008775 CTD increases(expression) FCER2 D008775 CTD decreases(expression) GFAP D008775 CTD affects(cotreatment) HTR3A D008775 CTD decreases(activity) HTR3A D008775 CTD affects(binding) IL4 D008775 CTD decreases(reaction) IL4 D008775 CTD increases(reaction) IL4 D008775 CTD increases(activity) IL4 D008775 CTD increases(phosphorylation) IL4 D008775 CTD increases(expression) IL4 D008775 CTD decreases(reaction) IL4R D008775 CTD increases(expression) IL4R D008775 CTD increases(phosphorylation) IL4R D008775 CTD decreases(reaction) JAK1 D008775 CTD increases(phosphorylation) JAK1 D008775 CTD decreases(expression) MBP D008775 CTD decreases(reaction) PLA1A D008775 CTD increases(expression) PLA1A D008775 CTD decreases(reaction) PLA2G4A D008775 CTD increases(expression) PLA2G4A D008775 CTD affects(binding) STAT6 D008775 CTD decreases(reaction) STAT6 D008775 CTD increases(reaction) STAT6 D008775 CTD increases(activity) STAT6 D008775 CTD increases(phosphorylation) STAT6 D008775 CTD decreases(expression) VWF D008775 CTD increases(expression) VWF D008775 PubChem None uM ABCB1 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.019 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 0.032 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 0.039 AR - GI(Protien) : PubChem Ratio Potency (uM) uM 0.047 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 0.049 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 0.051 AR - GI(Protien) : PubChem None uM CFTR - GI(Protien) : PubChem Potency uM 0.026 NFE2L2 - GI(Protien) : PubChem Potency uM 0.033 NFE2L2 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.021 NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.031 NR3C1 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.038 NR3C1 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : ChEMBL Potency nM 25.900 NFE2L2 - Target : CHEMBL1075094
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