Tan Lab | DSigDB

Gene Set: D4 : CTD - Methotrexate

Collection

D4 : CTD

Chemical Name

Methotrexate ( From PubChem : METHOTREXATE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
454.439 g/mol	5	13	1.8217	False(3/4)

Structure

InChI

InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

InChIKey

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Links

Gene (619 / 766)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			ABCB1		D008727
CTD	affects(response to substance)			ABCB1		D008727
CTD	increases(response to substance)			ABCB1		D008727
CTD	affects(cotreatment)			ABCB1		D008727
CTD	affects(response to substance)			ABCB1		D008727
CTD	increases(response to substance)			ABCB1		D008727
CTD	increases(expression)			ABCB1		D008727
CTD	affects(transport)			ABCC1		D008727
CTD	decreases(response to substance)			ABCC1		D008727
CTD	decreases(response to substance)			ABCC11		D008727
CTD	increases(response to substance)			ABCC2		D008727
CTD	affects(export)			ABCC2		D008727
CTD	decreases(response to substance)			ABCC2		D008727
CTD	affects(transport)			ABCC2		D008727
CTD	increases(response to substance)			ABCC2		D008727
CTD	decreases(response to substance)			ABCC2		D008727
CTD	decreases(reaction)			ABCC2		D008727
CTD	increases(export)			ABCC2		D008727
CTD	decreases(reaction)			ABCC4		D008727
CTD	increases(transport)			ABCC4		D008727
CTD	affects(transport)			ABCC4		D008727
CTD	decreases(reaction)			ABCC4		D008727
CTD	decreases(expression)			ABCD1		D008727
CTD	increases(expression)			ABCD3		D008727
CTD	affects(response to substance)			ABCG2		D008727
CTD	affects(transport)			ABCG2		D008727
CTD	decreases(response to substance)			ABCG2		D008727
CTD	decreases(response to substance)			ABCG2		D008727
CTD	increases(export)			ABCG2		D008727
CTD	increases(export)			ABCG2		D008727
CTD	increases(transport)			ABCG2		D008727
CTD	increases(reaction)			ABCG2		D008727
CTD	decreases(reaction)			ABCG2		D008727
CTD	increases(expression)			ACAA2		D008727
CTD	increases(expression)			ACACB		D008727
CTD	increases(expression)			ACADM		D008727
CTD	increases(expression)			ACADVL		D008727
CTD	increases(expression)			ACSL4		D008727
CTD	increases(expression)			ACSL6		D008727
CTD	increases(expression)			ACSS2		D008727
CTD	affects(response to substance)			ACTR1A		D008727
CTD	decreases(expression)			ADAMTS7		D008727
CTD	decreases(expression)			ADAT3		D008727
CTD	affects(response to substance)			ADGRL2		D008727
CTD	increases(expression)			ADIPOR1		D008727
CTD	increases(expression)			ADIPOR2		D008727
CTD	affects(response to substance)			ADIRF		D008727
CTD	decreases(expression)			ADM		D008727
CTD	increases(expression)			ADORA3		D008727
CTD	increases(expression)			AGPAT3		D008727
CTD	affects(response to substance)			AIM2		D008727
CTD	increases(expression)			AIP		D008727
CTD	decreases(expression)			ALOX12		D008727
CTD	affects(response to substance)			ALOX5		D008727
CTD	increases(activity)			ALPI		D008727
CTD	increases(reaction)			ALPI		D008727
CTD	decreases(reaction)			ALPI		D008727
CTD	affects(response to substance)			ALPP		D008727
CTD	increases(expression)			AMACR		D008727
CTD	increases(expression)			ANGEL2		D008727
CTD	increases(expression)			ANKH		D008727
CTD	increases(expression)			ANPEP		D008727
CTD	affects(response to substance)			ANXA11		D008727
CTD	affects(response to substance)			AOC1		D008727
CTD	affects(metabolic processing)			AOX1		D008727
CTD	decreases(expression)			AP3D1		D008727
CTD	decreases(expression)			APLN		D008727
CTD	decreases(expression)			APP		D008727
CTD	affects(response to substance)			ARFIP1		D008727
CTD	affects(response to substance)			ARHGDIA		D008727
CTD	decreases(expression)			ARHGDIB		D008727
CTD	affects(response to substance)			ARL6IP4		D008727
CTD	decreases(expression)			ASCL3		D008727
CTD	affects(response to substance)			ATF5		D008727
CTD	affects(response to substance)			ATIC		D008727
CTD	affects(response to substance)			ATP5D		D008727
CTD	increases(expression)			AUH		D008727
CTD	increases(secretion)			AVP		D008727
CTD	affects(response to substance)			B3GNT3		D008727
CTD	affects(response to substance)			BAG6		D008727
CTD	decreases(expression)			BCL2		D008727
CTD	affects(response to substance)			BNIP3		D008727
CTD	increases(reaction)			BRCA1		D008727
CTD	increases(response to substance)			BRCA1		D008727
CTD	affects(response to substance)			BST2		D008727
CTD	affects(response to substance)			BTBD3		D008727
CTD	decreases(expression)			C14ORF2		D008727
CTD	decreases(expression)			C16ORF58		D008727
CTD	decreases(expression)			C1QB		D008727
CTD	increases(expression)			C3		D008727
CTD	increases(expression)			C3ORF17		D008727
CTD	decreases(expression)			C3ORF36		D008727
CTD	increases(expression)			C5		D008727
CTD	decreases(expression)			C5AR1		D008727
CTD	increases(expression)			C8A		D008727
CTD	decreases(expression)			C8ORF33		D008727
CTD	affects(response to substance)			CALR		D008727
CTD	increases(expression)			CASP8		D008727
CTD	increases(expression)			CASP8		D008727
CTD	increases(reaction)			CASP8		D008727
CTD	increases(expression)			CAT		D008727
CTD	increases(expression)			CCDC82		D008727
CTD	decreases(expression)			CCL11		D008727
CTD	decreases(expression)			CCL13		D008727
CTD	decreases(expression)			CCL19		D008727
CTD	decreases(expression)			CCL2		D008727
CTD	decreases(expression)			CCL21		D008727
CTD	decreases(expression)			CCL25		D008727
CTD	decreases(expression)			CCL3		D008727
CTD	decreases(expression)			CCL3		D008727
CTD	decreases(reaction)			CCL3		D008727
CTD	decreases(expression)			CCL3L1		D008727
CTD	decreases(expression)			CCL4		D008727
CTD	decreases(expression)			CCL4		D008727
CTD	affects(reaction)			CCL4		D008727
CTD	decreases(expression)			CCL5		D008727
CTD	increases(expression)			CCL5		D008727
CTD	increases(reaction)			CCL5		D008727
CTD	decreases(expression)			CCL8		D008727
CTD	affects(response to substance)			CD151		D008727
CTD	decreases(expression)			CD19		D008727
CTD	decreases(expression)			CD1B		D008727
CTD	increases(expression)			CD1D		D008727
CTD	decreases(expression)			CD2		D008727
CTD	decreases(expression)			CD247		D008727
CTD	decreases(expression)			CD28		D008727
CTD	affects(response to substance)			CD302		D008727
CTD	decreases(expression)			CD3EAP		D008727
CTD	decreases(expression)			CD4		D008727
CTD	decreases(expression)			CD47		D008727
CTD	decreases(expression)			CD48		D008727
CTD	increases(expression)			CD58		D008727
CTD	decreases(expression)			CD68		D008727
CTD	increases(expression)			CD81		D008727
CTD	decreases(expression)			CD86		D008727
CTD	decreases(expression)			CD8A		D008727
CTD	decreases(expression)			CD93		D008727
CTD	affects(response to substance)			CD99		D008727
CTD	affects(response to substance)			CDC34		D008727
CTD	affects(response to substance)			CDK2AP2		D008727
CTD	increases(activity)			CDKN1A		D008727
CTD	increases(expression)			CDKN1A		D008727
CTD	increases(expression)			CDKN1A		D008727
CTD	increases(reaction)			CDKN1A		D008727
CTD	affects(reaction)			CDKN1A		D008727
CTD	affects(response to substance)			CDKN1B		D008727
CTD	decreases(expression)			CEACAM3		D008727
CTD	increases(expression)			CEACAM5		D008727
CTD	increases(expression)			CEACAM6		D008727
CTD	affects(response to substance)			CEP57		D008727
CTD	increases(expression)			CFAP44		D008727
CTD	affects(response to substance)			CGA		D008727
CTD	decreases(expression)			CHRNE		D008727
CTD	affects(response to substance)			CIZ1		D008727
CTD	affects(response to substance)			CKAP4		D008727
CTD	affects(response to substance)			CKMT1B		D008727
CTD	affects(response to substance)			CLN3		D008727
CTD	increases(expression)			CLN8		D008727
CTD	affects(response to substance)			CLPTM1		D008727
CTD	decreases(expression)			CLPTM1		D008727
CTD	affects(response to substance)			CLSTN1		D008727
CTD	affects(response to substance)			CNOT3		D008727
CTD	affects(response to substance)			COL15A1		D008727
CTD	affects(expression)			COL3A1		D008727
CTD	increases(expression)			COL3A1		D008727
CTD	increases(expression)			COL3A1		D008727
CTD	increases(expression)			COL4A4		D008727
CTD	decreases(expression)			COLEC12		D008727
CTD	decreases(expression)			CORO1A		D008727
CTD	decreases(expression)			COX6A1		D008727
CTD	decreases(expression)			COX6B1		D008727
CTD	affects(response to substance)			CPS1		D008727
CTD	affects(response to substance)			CPSF1		D008727
CTD	increases(expression)			CPT1A		D008727
CTD	affects(response to substance)			CREB3		D008727
CTD	decreases(expression)			CSF1		D008727
CTD	decreases(expression)			CSF1R		D008727
CTD	decreases(expression)			CSF3R		D008727
CTD	affects(response to substance)			CST1		D008727
CTD	affects(response to substance)			CST6		D008727
CTD	decreases(expression)			CST7		D008727
CTD	affects(response to substance)			CSTA		D008727
CTD	decreases(expression)			CTGF		D008727
CTD	affects(response to substance)			CTH		D008727
CTD	decreases(phosphorylation)			CTNNB1		D008727
CTD	increases(reaction)			CTNNB1		D008727
CTD	decreases(expression)			CTSG		D008727
CTD	decreases(expression)			CTSS		D008727
CTD	decreases(expression)			CXCL11		D008727
CTD	increases(expression)			CXCL12		D008727
CTD	decreases(expression)			CXCL8		D008727
CTD	increases(secretion)			CXCL8		D008727
CTD	decreases(reaction)			CXCL8		D008727
CTD	decreases(expression)			CXCR2		D008727
CTD	increases(expression)			CYCS		D008727
CTD	increases(expression)			CYP19A1		D008727
CTD	decreases(reaction)			CYP1A2		D008727
CTD	increases(activity)			CYP1A2		D008727
CTD	decreases(expression)			CYP3A4		D008727
CTD	increases(expression)			CYP4A11		D008727
CTD	increases(expression)			CYP4F3		D008727
CTD	increases(expression)			CYP4V2		D008727
CTD	affects(response to substance)			DAPK3		D008727
CTD	affects(response to substance)			DBN1		D008727
CTD	affects(response to substance)			DCP2		D008727
CTD	increases(expression)			DES		D008727
CTD	increases(expression)			DGAT1		D008727
CTD	increases(expression)			DGAT2		D008727
CTD	affects(response to substance)			DGCR6		D008727
CTD	decreases(response to substance)			DHFR		D008727
CTD	affects(response to substance)			DHRS2		D008727
CTD	affects(response to substance)			DHX15		D008727
CTD	increases(expression)			DIS3L		D008727
CTD	decreases(expression)			DKK1		D008727
CTD	increases(expression)			DLAT		D008727
CTD	increases(expression)			DMXL2		D008727
CTD	decreases(expression)			DNAJB5		D008727
CTD	increases(expression)			DNASE1		D008727
CTD	affects(response to substance)			DRAP1		D008727
CTD	increases(expression)			DUSP1		D008727
CTD	increases(expression)			DUSP10		D008727
CTD	increases(expression)			DUSP14		D008727
CTD	decreases(expression)			DUSP2		D008727
CTD	affects(response to substance)			DUSP4		D008727
CTD	increases(expression)			ECH1		D008727
CTD	increases(expression)			ECHS1		D008727
CTD	affects(response to substance)			EED		D008727
CTD	increases(expression)			EHHADH		D008727
CTD	affects(response to substance)			EIF5A		D008727
CTD	decreases(expression)			ELF1		D008727
CTD	decreases(expression)			EMC10		D008727
CTD	affects(response to substance)			ENOSF1		D008727
CTD	increases(expression)			EPAS1		D008727
CTD	affects(response to substance)			EPRS		D008727
CTD	affects(response to substance)			ERBB2		D008727
CTD	decreases(expression)			ESRRA		D008727
CTD	affects(response to substance)			ESYT1		D008727
CTD	affects(response to substance)			EVL		D008727
CTD	affects(response to substance)			EXOC7		D008727
CTD	affects(response to substance)			F12		D008727
CTD	increases(expression)			F2		D008727
CTD	increases(expression)			F2RL1		D008727
CTD	increases(expression)			F3		D008727
CTD	decreases(expression)			FA2H		D008727
CTD	increases(expression)			FABP1		D008727
CTD	affects(response to substance)			FADS1		D008727
CTD	increases(expression)			FADS1		D008727
CTD	affects(response to substance)			FADS2		D008727
CTD	decreases(expression)			FAM167B		D008727
CTD	affects(response to substance)			FAM171A1		D008727
CTD	decreases(expression)			FAM173A		D008727
CTD	increases(expression)			FAM63A		D008727
CTD	decreases(expression)			FAM89B		D008727
CTD	decreases(expression)			FAR1		D008727
CTD	decreases(expression)			FAS		D008727
CTD	increases(expression)			FAS		D008727
CTD	decreases(expression)			FCER1G		D008727
CTD	increases(expression)			FCGR2A		D008727
CTD	decreases(expression)			FCGR2B		D008727
CTD	decreases(expression)			FCGR3B		D008727
CTD	affects(response to substance)			FER		D008727
CTD	decreases(expression)			FGF12		D008727
CTD	decreases(expression)			FGF19		D008727
CTD	decreases(expression)			FGF8		D008727
CTD	affects(response to substance)			FGFR1		D008727
CTD	affects(response to substance)			FLRT2		D008727
CTD	affects(response to substance)			FMOD		D008727
CTD	increases(expression)			FN1		D008727
CTD	affects(response to substance)			FNBP1		D008727
CTD	affects(response to substance)			FOXN3		D008727
CTD	increases(metabolic processing)			FPGS		D008727
CTD	decreases(expression)			FPR1		D008727
CTD	decreases(expression)			FPR2		D008727
CTD	affects(response to substance)			FSTL1		D008727
CTD	decreases(expression)			FYB		D008727
CTD	affects(response to substance)			GAD1		D008727
CTD	affects(response to substance)			GAMT		D008727
CTD	increases(expression)			GATA3		D008727
CTD	increases(expression)			GCNT1		D008727
CTD	affects(response to substance)			GCSH		D008727
CTD	decreases(expression)			GEM		D008727
CTD	decreases(expression)			GFI1		D008727
CTD	decreases(expression)			GJA4		D008727
CTD	increases(expression)			GLYATL1		D008727
CTD	affects(response to substance)			GNA11		D008727
CTD	affects(response to substance)			GNE		D008727
CTD	affects(response to substance)			GNG11		D008727
CTD	increases(expression)			GPAM		D008727
CTD	decreases(expression)			GPR183		D008727
CTD	affects(response to substance)			GPX2		D008727
CTD	affects(response to substance)			GPX3		D008727
CTD	affects(response to substance)			GRIN3B		D008727
CTD	affects(response to substance)			GRN		D008727
CTD	increases(phosphorylation)			GSK3B		D008727
CTD	increases(reaction)			GSK3B		D008727
CTD	increases(expression)			GSTA2		D008727
CTD	affects(response to substance)			GSTM1		D008727
CTD	decreases(expression)			GZMA		D008727
CTD	affects(response to substance)			H1FX		D008727
CTD	affects(response to substance)			H2AFX		D008727
CTD	increases(expression)			HADHA		D008727
CTD	increases(expression)			HADHB		D008727
CTD	decreases(expression)			HCRT		D008727
CTD	affects(response to substance)			HDAC4		D008727
CTD	affects(response to substance)			HDGFRP3		D008727
CTD	affects(response to substance)			HDHD1		D008727
CTD	increases(expression)			HERC1		D008727
CTD	affects(response to substance)			HGS		D008727
CTD	increases(expression)			HIBCH		D008727
CTD	affects(response to substance)			HLA-A		D008727
CTD	decreases(expression)			HLA-DRA		D008727
CTD	decreases(expression)			HLA-G		D008727
CTD	affects(response to substance)			HNRNPH1		D008727
CTD	increases(expression)			HPGD		D008727
CTD	decreases(expression)			HPRT1		D008727
CTD	increases(expression)			HRH1		D008727
CTD	increases(expression)			HSD11B1		D008727
CTD	increases(expression)			HSD17B4		D008727
CTD	increases(expression)			HSH2D		D008727
CTD	decreases(expression)			HSPA1B		D008727
CTD	increases(expression)			HSPA4		D008727
CTD	increases(expression)			HSPB1		D008727
CTD	decreases(reaction)			HSPB1		D008727
CTD	decreases(expression)			ICAM1		D008727
CTD	decreases(expression)			ICOSLG		D008727
CTD	decreases(expression)			ID3		D008727
CTD	decreases(expression)			IFNG		D008727
CTD	increases(expression)			IFNG		D008727
CTD	affects(response to substance)			IGFBP7		D008727
CTD	increases(expression)			IL10		D008727
CTD	decreases(reaction)			IL10		D008727
CTD	decreases(expression)			IL15RA		D008727
CTD	decreases(expression)			IL16		D008727
CTD	decreases(expression)			IL17A		D008727
CTD	increases(expression)			IL17RB		D008727
CTD	increases(expression)			IL18		D008727
CTD	decreases(expression)			IL18RAP		D008727
CTD	decreases(expression)			IL1A		D008727
CTD	increases(expression)			IL1A		D008727
CTD	decreases(reaction)			IL1B		D008727
CTD	increases(chemical synthesis)			IL1B		D008727
CTD	increases(expression)			IL1B		D008727
CTD	increases(expression)			IL1B		D008727
CTD	decreases(reaction)			IL1B		D008727
CTD	decreases(expression)			IL1R2		D008727
CTD	decreases(expression)			IL1RL1		D008727
CTD	increases(expression)			IL2		D008727
CTD	affects(reaction)			IL2		D008727
CTD	decreases(expression)			IL2RB		D008727
CTD	decreases(expression)			IL3		D008727
CTD	decreases(expression)			IL32		D008727
CTD	decreases(expression)			IL4		D008727
CTD	decreases(expression)			IL4		D008727
CTD	decreases(reaction)			IL4		D008727
CTD	affects(cotreatment)			IL6		D008727
CTD	decreases(reaction)			IL6		D008727
CTD	increases(secretion)			IL6		D008727
CTD	decreases(expression)			IL6		D008727
CTD	affects(reaction)			IL6		D008727
CTD	decreases(expression)			IMPDH1		D008727
CTD	decreases(expression)			IMPDH2		D008727
CTD	decreases(expression)			INPP4A		D008727
CTD	decreases(expression)			INS		D008727
CTD	increases(expression)			INSR		D008727
CTD	increases(expression)			IRAK4		D008727
CTD	affects(response to substance)			IRF6		D008727
CTD	increases(expression)			ITGA1		D008727
CTD	increases(expression)			ITGA5		D008727
CTD	increases(expression)			ITGAL		D008727
CTD	affects(response to substance)			ITPR1		D008727
CTD	decreases(expression)			JAK3		D008727
CTD	affects(response to substance)			KCMF1		D008727
CTD	affects(response to substance)			KCNK1		D008727
CTD	decreases(expression)			KCNK7		D008727
CTD	affects(response to substance)			KDELR1		D008727
CTD	affects(response to substance)			KDM6A		D008727
CTD	decreases(expression)			KISS1		D008727
CTD	decreases(expression)			KITLG		D008727
CTD	decreases(expression)			KLF2		D008727
CTD	increases(expression)			KLHDC10		D008727
CTD	decreases(expression)			KLHDC7B		D008727
CTD	affects(response to substance)			KLK6		D008727
CTD	increases(expression)			KLKB1		D008727
CTD	affects(response to substance)			KLRC2		D008727
CTD	decreases(expression)			KLRD1		D008727
CTD	affects(response to substance)			KRR1		D008727
CTD	decreases(expression)			KRT71		D008727
CTD	decreases(expression)			KRT82		D008727
CTD	decreases(expression)			LAGE3		D008727
CTD	affects(response to substance)			LAMC1		D008727
CTD	increases(expression)			LBP		D008727
CTD	affects(response to substance)			LCK		D008727
CTD	decreases(expression)			LGR5		D008727
CTD	decreases(expression)			LILRB1		D008727
CTD	decreases(expression)			LILRB2		D008727
CTD	decreases(expression)			LILRB3		D008727
CTD	affects(response to substance)			LPAR1		D008727
CTD	affects(response to substance)			LPAR2		D008727
CTD	decreases(expression)			LPPR4		D008727
CTD	increases(expression)			LSP1		D008727
CTD	decreases(expression)			LY96		D008727
CTD	affects(response to substance)			MAGEA6		D008727
CTD	affects(response to substance)			MAGED1		D008727
CTD	increases(expression)			MALT1		D008727
CTD	affects(response to substance)			MAP2K2		D008727
CTD	affects(response to substance)			MAP2K6		D008727
CTD	decreases(expression)			MAP2K6		D008727
CTD	increases(phosphorylation)			MAP3K7		D008727
CTD	affects(response to substance)			MAP7		D008727
CTD	decreases(expression)			MAPK14		D008727
CTD	increases(phosphorylation)			MAPK14		D008727
CTD	decreases(reaction)			MAPK14		D008727
CTD	affects(expression)			MAPKAPK2		D008727
CTD	increases(expression)			MAPKAPK2		D008727
CTD	decreases(reaction)			MAPKAPK2		D008727
CTD	affects(response to substance)			MBD3		D008727
CTD	increases(expression)			MBP		D008727
CTD	increases(expression)			MBP		D008727
CTD	affects(response to substance)			MCF2L		D008727
CTD	increases(activity)			MDM2		D008727
CTD	increases(expression)			MDM2		D008727
CTD	increases(expression)			MDM2		D008727
CTD	increases(reaction)			MDM2		D008727
CTD	affects(reaction)			MDM2		D008727
CTD	increases(expression)			MECR		D008727
CTD	affects(response to substance)			MED15		D008727
CTD	affects(response to substance)			MED16		D008727
CTD	affects(response to substance)			MEGF9		D008727
CTD	decreases(expression)			MFAP4		D008727
CTD	affects(response to substance)			MFGE8		D008727
CTD	decreases(expression)			MIS18A		D008727
CTD	increases(expression)			MLXIP		D008727
CTD	decreases(expression)			MMP3		D008727
CTD	affects(response to substance)			MPHOSPH6		D008727
CTD	decreases(expression)			MRGPRX2		D008727
CTD	decreases(expression)			MRVI1		D008727
CTD	affects(response to substance)			MSLN		D008727
CTD	affects(metabolic processing)			MTHFR		D008727
CTD	affects(response to substance)			MTHFR		D008727
CTD	affects(response to substance)			MTHFR		D008727
CTD	decreases(metabolic processing)			MTHFR		D008727
CTD	increases(response to substance)			MTHFR		D008727
CTD	affects(response to substance)			MTHFR		D008727
CTD	increases(expression)			MTM1		D008727
CTD	decreases(expression)			MTMR7		D008727
CTD	decreases(expression)			MTR		D008727
CTD	decreases(reaction)			MTR		D008727
CTD	affects(metabolic processing)			MTR		D008727
CTD	affects(cotreatment)			MTR		D008727
CTD	decreases(expression)			MUC6		D008727
CTD	decreases(expression)			MYC		D008727
CTD	affects(response to substance)			MYO1E		D008727
CTD	affects(response to substance)			MYO6		D008727
CTD	decreases(activity)			NAT1		D008727
CTD	decreases(expression)			NBL1		D008727
CTD	increases(expression)			NBR1		D008727
CTD	decreases(expression)			NCF4		D008727
CTD	decreases(expression)			NCK1		D008727
CTD	affects(response to substance)			NDUFS8		D008727
CTD	increases(expression)			NFAT5		D008727
CTD	increases(expression)			NFATC3		D008727
CTD	affects(response to substance)			NFE2L1		D008727
CTD	affects(response to substance)			NFKB2		D008727
CTD	increases(expression)			NGF		D008727
CTD	increases(expression)			NINL		D008727
CTD	decreases(expression)			NOD2		D008727
CTD	decreases(reaction)			NOS2		D008727
CTD	increases(chemical synthesis)			NOS2		D008727
CTD	increases(expression)			NOS2		D008727
CTD	decreases(expression)			NOS2		D008727
CTD	affects(response to substance)			NOS3		D008727
CTD	decreases(expression)			NPTN		D008727
CTD	decreases(expression)			NR3C1		D008727
CTD	affects(response to substance)			NUP88		D008727
CTD	decreases(expression)			NXN		D008727
CTD	increases(expression)			OCRL		D008727
CTD	increases(expression)			ODC1		D008727
CTD	decreases(expression)			OGN		D008727
CTD	increases(expression)			OPRK1		D008727
CTD	affects(response to substance)			P4HB		D008727
CTD	affects(response to substance)			PAPOLA		D008727
CTD	increases(cleavage)			PARP1		D008727
CTD	increases(expression)			PCK1		D008727
CTD	increases(expression)			PCYOX1		D008727
CTD	increases(expression)			PDCD7		D008727
CTD	decreases(expression)			PDGFB		D008727
CTD	affects(response to substance)			PDK1		D008727
CTD	affects(response to substance)			PDLIM7		D008727
CTD	increases(expression)			PECR		D008727
CTD	affects(response to substance)			PER2		D008727
CTD	affects(response to substance)			PEX11A		D008727
CTD	increases(expression)			PEX7		D008727
CTD	decreases(expression)			PF4		D008727
CTD	affects(response to substance)			PHACTR2		D008727
CTD	affects(response to substance)			PHF10		D008727
CTD	increases(expression)			PHYH		D008727
CTD	affects(response to substance)			PI3		D008727
CTD	affects(response to substance)			PIK3C2B		D008727
CTD	affects(response to substance)			PIN1		D008727
CTD	decreases(reaction)			PLA1A		D008727
CTD	increases(expression)			PLA1A		D008727
CTD	increases(expression)			PLA2G2A		D008727
CTD	increases(expression)			PLCXD1		D008727
CTD	affects(response to substance)			PLD3		D008727
CTD	decreases(expression)			PLSCR1		D008727
CTD	increases(expression)			PLXNB1		D008727
CTD	affects(response to substance)			PNMA2		D008727
CTD	increases(expression)			PNPLA3		D008727
CTD	decreases(expression)			PNPLA4		D008727
CTD	affects(response to substance)			PPAP2A		D008727
CTD	increases(expression)			PPAP2B		D008727
CTD	increases(expression)			PPARA		D008727
CTD	decreases(expression)			PPARD		D008727
CTD	affects(response to substance)			PPID		D008727
CTD	increases(expression)			PPIL4		D008727
CTD	affects(response to substance)			PPP2R5C		D008727
CTD	affects(response to substance)			PPP3CA		D008727
CTD	affects(response to substance)			PPRC1		D008727
CTD	decreases(expression)			PRC1		D008727
CTD	increases(expression)			PRKAG2		D008727
CTD	decreases(expression)			PRL		D008727
CTD	decreases(expression)			PRNP		D008727
CTD	increases(expression)			PROS1		D008727
CTD	decreases(expression)			PRR3		D008727
CTD	decreases(expression)			PRTN3		D008727
CTD	affects(response to substance)			PSAP		D008727
CTD	increases(expression)			PTEN		D008727
CTD	decreases(expression)			PTGIS		D008727
CTD	affects(response to substance)			PTOV1		D008727
CTD	decreases(expression)			PTPRC		D008727
CTD	affects(response to substance)			PTPRG		D008727
CTD	affects(response to substance)			PVRL2		D008727
CTD	increases(expression)			PXN		D008727
CTD	decreases(expression)			PYCRL		D008727
CTD	decreases(activity)			QDPR		D008727
CTD	affects(response to substance)			RAB11FIP2		D008727
CTD	affects(response to substance)			RAB1A		D008727
CTD	decreases(expression)			RAB6C		D008727
CTD	increases(expression)			RAC1		D008727
CTD	increases(expression)			RALGPS2		D008727
CTD	decreases(expression)			RAMP1		D008727
CTD	decreases(expression)			RAMP2		D008727
CTD	affects(response to substance)			RB1		D008727
CTD	affects(response to substance)			RB1		D008727
CTD	increases(response to substance)			RB1		D008727
CTD	affects(response to substance)			RBMS1		D008727
CTD	decreases(expression)			RELB		D008727
CTD	decreases(expression)			RGS1		D008727
CTD	decreases(expression)			RGS2		D008727
CTD	decreases(expression)			RGS4		D008727
CTD	increases(expression)			RP2		D008727
CTD	affects(response to substance)			RPL23A		D008727
CTD	decreases(expression)			RPL26		D008727
CTD	increases(expression)			RSAD1		D008727
CTD	decreases(expression)			S100A11		D008727
CTD	decreases(expression)			S100A9		D008727
CTD	affects(response to substance)			S100P		D008727
CTD	decreases(expression)			SCAND1		D008727
CTD	increases(expression)			SCD		D008727
CTD	affects(response to substance)			SDF4		D008727
CTD	increases(expression)			SDS		D008727
CTD	decreases(expression)			SEC23B		D008727
CTD	increases(expression)			SEC31B		D008727
CTD	decreases(expression)			SELE		D008727
CTD	decreases(expression)			SELL		D008727
CTD	decreases(expression)			SEMA4A		D008727
CTD	affects(response to substance)			SEMG1		D008727
CTD	increases(expression)			SEPP1		D008727
CTD	decreases(expression)			SERF2		D008727
CTD	decreases(expression)			SERPINH1		D008727
CTD	increases(expression)			SETD6		D008727
CTD	affects(response to substance)			SF3B1		D008727
CTD	decreases(expression)			SF3B3		D008727
CTD	decreases(expression)			SFTPB		D008727
CTD	affects(response to substance)			SGCE		D008727
CTD	affects(response to substance)			SH3BGRL3		D008727
CTD	affects(response to substance)			SH3GLB2		D008727
CTD	affects(response to substance)			SHMT1		D008727
CTD	decreases(expression)			SIRT2		D008727
CTD	decreases(expression)			SKA2		D008727
CTD	decreases(expression)			SKA3		D008727
CTD	affects(response to substance)			SKAP1		D008727
CTD	decreases(expression)			SLC11A1		D008727
CTD	decreases(reaction)			SLC19A1		D008727
CTD	increases(transport)			SLC19A1		D008727
CTD	decreases(activity)			SLC19A1		D008727
CTD	decreases(uptake)			SLC19A1		D008727
CTD	affects(reaction)			SLC19A1		D008727
CTD	decreases(response to substance)			SLC19A1		D008727
CTD	affects(response to substance)			SLC19A1		D008727
CTD	affects(response to substance)			SLC19A1		D008727
CTD	increases(response to substance)			SLC19A1		D008727
CTD	increases(transport)			SLC19A1		D008727
CTD	increases(uptake)			SLC22A6		D008727
CTD	increases(uptake)			SLC22A7		D008727
CTD	affects(transport)			SLC22A8		D008727
CTD	increases(uptake)			SLC22A8		D008727
CTD	affects(response to substance)			SLC26A2		D008727
CTD	decreases(expression)			SLC27A1		D008727
CTD	increases(expression)			SLC27A2		D008727
CTD	affects(response to substance)			SLC27A2		D008727
CTD	increases(expression)			SLC31A2		D008727
CTD	decreases(expression)			SLC38A10		D008727
CTD	decreases(reaction)			SLC46A1		D008727
CTD	increases(transport)			SLC46A1		D008727
CTD	decreases(activity)			SLC46A1		D008727
CTD	decreases(reaction)			SLC46A1		D008727
CTD	increases(uptake)			SLC46A1		D008727
CTD	increases(response to substance)			SLC46A1		D008727
CTD	increases(transport)			SLC46A1		D008727
CTD	increases(expression)			SLC47A1		D008727
CTD	affects(response to substance)			SLC52A2		D008727
CTD	decreases(expression)			SLCO2A1		D008727
CTD	affects(response to substance)			SLMO2		D008727
CTD	affects(response to substance)			SPG20		D008727
CTD	decreases(expression)			SPHK1		D008727
CTD	decreases(expression)			SPHK2		D008727
CTD	decreases(expression)			SRC		D008727
CTD	decreases(expression)			SRM		D008727
CTD	increases(expression)			STAT4		D008727
CTD	decreases(expression)			STAT5A		D008727
CTD	increases(expression)			STX16		D008727
CTD	affects(response to substance)			SUCLG2		D008727
CTD	increases(expression)			SUGP2		D008727
CTD	increases(expression)			SULT2A1		D008727
CTD	increases(expression)			SUN1		D008727
CTD	increases(expression)			SYNJ2		D008727
CTD	decreases(expression)			TAGLN		D008727
CTD	decreases(expression)			TAOK2		D008727
CTD	decreases(expression)			TBKBP1		D008727
CTD	increases(expression)			TCF12		D008727
CTD	affects(response to substance)			TCF12		D008727
CTD	decreases(expression)			TCF21		D008727
CTD	affects(metabolic processing)			TCN2		D008727
CTD	decreases(expression)			TENM1		D008727
CTD	decreases(expression)			TGFB1		D008727
CTD	affects(response to substance)			TGFB1		D008727
CTD	decreases(expression)			THBS1		D008727
CTD	decreases(expression)			THNSL1		D008727
CTD	affects(response to substance)			TLE1		D008727
CTD	affects(response to substance)			TLN1		D008727
CTD	decreases(expression)			TLR4		D008727
CTD	affects(response to substance)			TMEFF1		D008727
CTD	affects(response to substance)			TMEM259		D008727
CTD	increases(expression)			TNC		D008727
CTD	affects(cotreatment)			TNF		D008727
CTD	decreases(reaction)			TNF		D008727
CTD	increases(secretion)			TNF		D008727
CTD	decreases(expression)			TNF		D008727
CTD	decreases(reaction)			TNF		D008727
CTD	decreases(expression)			TNFAIP8		D008727
CTD	increases(expression)			TNFRSF10A		D008727
CTD	increases(expression)			TNFRSF10B		D008727
CTD	increases(secretion)			TNFRSF11B		D008727
CTD	decreases(expression)			TNFRSF9		D008727
CTD	decreases(expression)			TNFSF11		D008727
CTD	increases(expression)			TNFSF4		D008727
CTD	decreases(expression)			TNFSF9		D008727
CTD	increases(expression)			TNRC6A		D008727
CTD	affects(response to substance)			TOB1		D008727
CTD	decreases(expression)			TOM1		D008727
CTD	increases(expression)			TOMM40		D008727
CTD	decreases(expression)			TOR2A		D008727
CTD	increases(reaction)			TP53		D008727
CTD	increases(response to substance)			TP53		D008727
CTD	decreases(expression)			TP53		D008727
CTD	increases(expression)			TP53		D008727
CTD	increases(reaction)			TP53		D008727
CTD	affects(reaction)			TP53		D008727
CTD	increases(activity)			TP53		D008727
CTD	increases(expression)			TP53		D008727
CTD	increases(reaction)			TP53		D008727
CTD	increases(expression)			TPCN1		D008727
CTD	increases(expression)			TRAF3		D008727
CTD	affects(response to substance)			TRIM28		D008727
CTD	increases(expression)			TSC2		D008727
CTD	affects(response to substance)			TSPAN4		D008727
CTD	affects(response to substance)			TTF2		D008727
CTD	affects(response to substance)			TYK2		D008727
CTD	affects(response to substance)			TYMS		D008727
CTD	decreases(response to substance)			TYMS		D008727
CTD	affects(response to substance)			TYMS		D008727
CTD	increases(response to substance)			TYMS		D008727
CTD	increases(response to substance)			TYMS		D008727
CTD	decreases(expression)			TYROBP		D008727
CTD	affects(response to substance)			UBA1		D008727
CTD	decreases(expression)			UBE2C		D008727
CTD	decreases(expression)			UBQLN3		D008727
CTD	affects(response to substance)			UGCG		D008727
CTD	increases(expression)			UGT1A1		D008727
CTD	decreases(expression)			UGT1A10		D008727
CTD	increases(expression)			UGT1A4		D008727
CTD	increases(expression)			UGT1A6		D008727
CTD	decreases(response to substance)			UGT1A6		D008727
CTD	decreases(expression)			UGT1A8		D008727
CTD	decreases(expression)			UGT1A9		D008727
CTD	affects(response to substance)			UQCR11		D008727
CTD	affects(response to substance)			USH1C		D008727
CTD	increases(expression)			UVSSA		D008727
CTD	decreases(expression)			VAV2		D008727
CTD	decreases(expression)			VAV3		D008727
CTD	decreases(expression)			VCAM1		D008727
CTD	affects(response to substance)			VDR		D008727
CTD	decreases(expression)			VPS13B		D008727
CTD	affects(response to substance)			VWA5A		D008727
CTD	affects(response to substance)			WDR18		D008727
CTD	increases(expression)			WDR26		D008727
CTD	affects(response to substance)			WDR3		D008727
CTD	decreases(expression)			WDR45B		D008727
CTD	increases(expression)			WDR59		D008727
CTD	decreases(expression)			WISP1		D008727
CTD	increases(expression)			WNT5A		D008727
CTD	increases(expression)			XRCC6BP1		D008727
CTD	decreases(expression)			YTHDF2		D008727
CTD	increases(expression)			ZBTB43		D008727
CTD	increases(expression)			ZCCHC8		D008727
CTD	increases(expression)			ZFP14		D008727
CTD	increases(expression)			ZHX3		D008727
CTD	increases(expression)			ZNF10		D008727
CTD	affects(response to substance)			ZNF175		D008727
CTD	affects(response to substance)			ZNF580		D008727
CTD	increases(expression)			ZNF614		D008727
CTD	increases(expression)			ZNF638		D008727
PubChem	Potency	uM	7.519	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	7.943	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	0.005	IDH1	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency	uM	79.433	MPHOSPH8	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	IC50	uM	0.211	NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.010	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.060	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.154	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.581	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	1.458	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.376	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	Potency	uM	39.811	POLB	-	GI(Protien) :
PubChem	Potency	uM	31.623	POLH	-	GI(Protien) :
PubChem	Potency	uM	31.623	POLI	-	GI(Protien) :
PubChem	Potency	uM	0.447	PPARG	-	GI(Protien) :
PubChem	Potency	uM	0.010	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.011	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.021	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.041	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.126	TDP1	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	Potency	uM	39.811	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	19952.600	APEX1	-	Target : CHEMBL5619
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	7519.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	79432.800	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	580.500	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	1458.100	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	39810.700	POLB	-	Target : CHEMBL2392

Download gene sets

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