Tan Lab | DSigDB

Gene Set: D4 : CTD - Methimazole

Collection

D4 : CTD

Chemical Name

Methimazole ( From PubChem : METHIMAZOLE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
114.169 g/mol	1	2	1.0827	True

Structure

InChI

InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

InChIKey

Links

Gene (31 / 39)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCB11		D008713
CTD	decreases(expression)			CAT		D008713
CTD	increases(expression)			CCL2		D008713
CTD	increases(expression)			CNST		D008713
CTD	increases(expression)			CXCL8		D008713
CTD	increases(expression)			DIO1		D008713
CTD	increases(oxidation)			FMO1		D008713
CTD	decreases(oxidation)			FMO2		D008713
CTD	increases(oxidation)			FMO2		D008713
CTD	affects(metabolic processing)			FMO3		D008713
CTD	increases(metabolic processing)			FMO3		D008713
CTD	increases(expression)			GCLC		D008713
CTD	increases(expression)			GULP1		D008713
CTD	decreases(expression)			HAMP		D008713
CTD	increases(expression)			HAMP		D008713
CTD	increases(expression)			HP		D008713
CTD	increases(expression)			ID2		D008713
CTD	increases(expression)			ID3		D008713
CTD	increases(expression)			IL6		D008713
CTD	increases(expression)			ITGB5		D008713
CTD	increases(expression)			KLF9		D008713
CTD	increases(expression)			LGALS3		D008713
CTD	increases(expression)			LRP2		D008713
CTD	increases(expression)			MGST1		D008713
CTD	increases(activity)			PON1		D008713
CTD	increases(expression)			SLC5A5		D008713
CTD	increases(expression)			TBX3		D008713
CTD	increases(expression)			TGOLN2		D008713
CTD	decreases(activity)			TPO		D008713
CTD	decreases(activity)			TPO		D008713
CTD	decreases(reaction)			TPO		D008713
CTD	increases(expression)			TSHB		D008713
CTD	increases(reaction)			TSHB		D008713
CTD	decreases(expression)			TSHR		D008713
CTD	increases(expression)			TSHR		D008713
CTD	increases(expression)			ZNF676		D008713
PubChem	Potency	uM	44.668	EHMT2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.950	HSPB1	-	GI(Protien) :
ChEMBL	Potency	nM	44668.400	EHMT2	-	Target : CHEMBL6032

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