Tan Lab | DSigDB

Gene Set: D4 : CTD - Metformin

Collection

D4 : CTD

Chemical Name

Metformin ( From PubChem : METFORMIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
129.164 g/mol	3	5	0.2565	True

Structure

InChI

InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)

InChIKey

XZWYZXLIPXDOLR-UHFFFAOYSA-N

Links

Gene (83 / 209)

⊖ Less

Source	Type	Gene	Other
CTD	decreases(reaction)	ABCB1	D008687
CTD	increases(expression)	ABCB1	D008687
CTD	decreases(expression)	ABCB1	D008687
CTD	affects(reaction)	ABCB1	D008687
CTD	increases(expression)	ABCC2	D008687
CTD	decreases(expression)	ACACA	D008687
CTD	increases(phosphorylation)	ACACA	D008687
CTD	increases(phosphorylation)	ACACB	D008687
CTD	decreases(expression)	ADIPOQ	D008687
CTD	increases(reaction)	ADIPOQ	D008687
CTD	affects(cotreatment)	AKT1	D008687
CTD	increases(phosphorylation)	AKT1	D008687
CTD	decreases(reaction)	AKT1	D008687
CTD	increases(phosphorylation)	AKT1	D008687
CTD	affects(response to substance)	ATM	D008687
CTD	increases(expression)	BAD	D008687
CTD	increases(reaction)	BAD	D008687
CTD	increases(expression)	BAX	D008687
CTD	increases(reaction)	BAX	D008687
CTD	decreases(expression)	BCL2	D008687
CTD	increases(reaction)	BCL2	D008687
CTD	decreases(expression)	BCL2L1	D008687
CTD	increases(reaction)	BCL2L1	D008687
CTD	increases(activity)	CASP3	D008687
CTD	increases(reaction)	CASP3	D008687
CTD	decreases(reaction)	CASP3	D008687
CTD	increases(cleavage)	CASP3	D008687
CTD	decreases(activity)	CASP3	D008687
CTD	increases(activity)	CASP7	D008687
CTD	increases(reaction)	CASP7	D008687
CTD	decreases(reaction)	CASP7	D008687
CTD	increases(cleavage)	CASP7	D008687
CTD	decreases(activity)	CASP8	D008687
CTD	decreases(expression)	CAT	D008687
CTD	decreases(expression)	CCL2	D008687
CTD	decreases(expression)	CFD	D008687
CTD	increases(expression)	COX1	D008687
CTD	decreases(expression)	CRP	D008687
CTD	decreases(reaction)	CXCL8	D008687
CTD	increases(secretion)	CXCL8	D008687
CTD	increases(expression)	CXCL8	D008687
CTD	decreases(expression)	CYBA	D008687
CTD	increases(expression)	CYP1A2	D008687
CTD	decreases(reaction)	CYP3A4	D008687
CTD	increases(expression)	CYP3A4	D008687
CTD	decreases(expression)	CYP3A4	D008687
CTD	increases(expression)	CYP3A4	D008687
CTD	decreases(phosphorylation)	EIF4EBP1	D008687
CTD	affects(binding)	ESR1	D008687
CTD	decreases(reaction)	ESR1	D008687
CTD	increases(reaction)	ESR1	D008687
CTD	decreases(expression)	FASN	D008687
CTD	affects(localization)	FOS	D008687
CTD	decreases(reaction)	FOS	D008687
CTD	increases(expression)	GADD45A	D008687
CTD	increases(phosphorylation)	GSK3B	D008687
CTD	increases(expression)	GSN	D008687
CTD	decreases(expression)	HMOX1	D008687
CTD	increases(reaction)	HMOX1	D008687
CTD	decreases(response to substance)	HMOX1	D008687
CTD	increases(expression)	HMOX1	D008687
CTD	affects(binding)	HRH2	D008687
CTD	affects(response to substance)	HRH2	D008687
CTD	decreases(activity)	HRH2	D008687
CTD	affects(cotreatment)	IGF1	D008687
CTD	decreases(expression)	IGF1	D008687
CTD	increases(phosphorylation)	IGF1	D008687
CTD	affects(cotreatment)	IGF1R	D008687
CTD	decreases(expression)	IGF1R	D008687
CTD	affects(cotreatment)	IGF2	D008687
CTD	decreases(expression)	IGF2	D008687
CTD	increases(phosphorylation)	IGF2	D008687
CTD	affects(cotreatment)	IGF2R	D008687
CTD	decreases(expression)	IGF2R	D008687
CTD	decreases(expression)	IGFBP1	D008687
CTD	decreases(reaction)	IL1B	D008687
CTD	increases(phosphorylation)	IL1B	D008687
CTD	increases(secretion)	IL1B	D008687
CTD	increases(expression)	IL1B	D008687
CTD	decreases(reaction)	IL6	D008687
CTD	increases(secretion)	IL6	D008687
CTD	decreases(expression)	IL6	D008687
CTD	affects(cotreatment)	INS	D008687
CTD	decreases(expression)	INS	D008687
CTD	increases(phosphorylation)	INS	D008687
CTD	increases(reaction)	INS	D008687
CTD	increases(secretion)	INS	D008687
CTD	decreases(expression)	INS	D008687
CTD	decreases(secretion)	INS	D008687
CTD	decreases(expression)	INS	D008687
CTD	increases(expression)	INS	D008687
CTD	affects(cotreatment)	INSR	D008687
CTD	decreases(expression)	INSR	D008687
CTD	affects(reaction)	IRS1	D008687
CTD	decreases(expression)	IRS1	D008687
CTD	affects(localization)	JUN	D008687
CTD	decreases(reaction)	JUN	D008687
CTD	increases(expression)	JUND	D008687
CTD	increases(expression)	KRT80	D008687
CTD	decreases(reaction)	MAPK1	D008687
CTD	increases(phosphorylation)	MAPK1	D008687
CTD	decreases(reaction)	MAPK1	D008687
CTD	increases(phosphorylation)	MAPK1	D008687
CTD	decreases(phosphorylation)	MAPK1	D008687
CTD	decreases(reaction)	MAPK10	D008687
CTD	increases(phosphorylation)	MAPK10	D008687
CTD	decreases(reaction)	MAPK3	D008687
CTD	increases(phosphorylation)	MAPK3	D008687
CTD	decreases(reaction)	MAPK3	D008687
CTD	increases(phosphorylation)	MAPK3	D008687
CTD	decreases(phosphorylation)	MAPK3	D008687
CTD	decreases(reaction)	MAPK9	D008687
CTD	increases(phosphorylation)	MAPK9	D008687
CTD	increases(expression)	MEF2A	D008687
CTD	increases(expression)	MEF2C	D008687
CTD	increases(expression)	MEF2D	D008687
CTD	decreases(reaction)	MMP2	D008687
CTD	increases(expression)	MMP2	D008687
CTD	decreases(activity)	MMP2	D008687
CTD	decreases(expression)	MMP2	D008687
CTD	decreases(reaction)	MMP9	D008687
CTD	increases(activity)	MMP9	D008687
CTD	increases(expression)	MMP9	D008687
CTD	decreases(activity)	MMP9	D008687
CTD	decreases(expression)	MMP9	D008687
CTD	increases(expression)	MYC	D008687
CTD	affects(expression)	NAMPT	D008687
CTD	affects(reaction)	NAMPT	D008687
CTD	affects(localization)	NFE2L2	D008687
CTD	decreases(reaction)	NFE2L2	D008687
CTD	increases(stability)	NFE2L2	D008687
CTD	decreases(expression)	NFE2L2	D008687
CTD	decreases(degradation)	NFKBIA	D008687
CTD	decreases(phosphorylation)	NFKBIA	D008687
CTD	decreases(expression)	NQO1	D008687
CTD	increases(expression)	NRF1	D008687
CTD	increases(activity)	PLAT	D008687
CTD	affects(binding)	POU5F1	D008687
CTD	decreases(reaction)	POU5F1	D008687
CTD	increases(reaction)	POU5F1	D008687
CTD	decreases(expression)	PPARG	D008687
CTD	increases(expression)	PPARGC1A	D008687
CTD	affects(reaction)	PPARGC1A	D008687
CTD	increases(expression)	PPARGC1A	D008687
CTD	decreases(activity)	PRKAA1	D008687
CTD	decreases(phosphorylation)	PRKAA1	D008687
CTD	decreases(reaction)	PRKAA1	D008687
CTD	increases(activity)	PRKAA1	D008687
CTD	increases(phosphorylation)	PRKAA1	D008687
CTD	affects(reaction)	PRKAA1	D008687
CTD	decreases(reaction)	PRKAA1	D008687
CTD	increases(chemical synthesis)	PRKAA1	D008687
CTD	affects(reaction)	PRKAA1	D008687
CTD	decreases(expression)	PRKAA1	D008687
CTD	increases(expression)	PRKAA1	D008687
CTD	affects(response to substance)	PRKAA1	D008687
CTD	increases(activity)	PRKAA2	D008687
CTD	increases(phosphorylation)	PRKAA2	D008687
CTD	decreases(reaction)	PRKCA	D008687
CTD	increases(phosphorylation)	PRKCA	D008687
CTD	decreases(expression)	PRKCB	D008687
CTD	decreases(secretion)	PRL	D008687
CTD	decreases(phosphorylation)	RAF1	D008687
CTD	decreases(reaction)	RELA	D008687
CTD	increases(phosphorylation)	RELA	D008687
CTD	decreases(reaction)	RELA	D008687
CTD	increases(expression)	RELA	D008687
CTD	affects(localization)	RELA	D008687
CTD	decreases(expression)	RELA	D008687
CTD	decreases(localization)	RELA	D008687
CTD	affects(reaction)	RELA	D008687
CTD	affects(expression)	SIRT1	D008687
CTD	affects(reaction)	SIRT1	D008687
CTD	decreases(reaction)	SLC15A1	D008687
CTD	increases(activity)	SLC15A1	D008687
CTD	increases(expression)	SLC15A1	D008687
CTD	decreases(activity)	SLC15A1	D008687
CTD	decreases(expression)	SLC15A1	D008687
CTD	decreases(reaction)	SLC22A1	D008687
CTD	increases(uptake)	SLC22A1	D008687
CTD	increases(response to substance)	SLC22A1	D008687
CTD	decreases(reaction)	SLC22A2	D008687
CTD	increases(uptake)	SLC22A2	D008687
CTD	decreases(reaction)	SLC22A2	D008687
CTD	increases(uptake)	SLC22A2	D008687
CTD	decreases(reaction)	SLC22A2	D008687
CTD	increases(uptake)	SLC22A2	D008687
CTD	affects(transport)	SLC22A2	D008687
CTD	decreases(reaction)	SLC22A2	D008687
CTD	decreases(transport)	SLC22A2	D008687
CTD	increases(uptake)	SLC22A2	D008687
CTD	decreases(reaction)	SLC22A3	D008687
CTD	increases(uptake)	SLC22A3	D008687
CTD	decreases(reaction)	SLC22A3	D008687
CTD	increases(uptake)	SLC22A3	D008687
CTD	affects(reaction)	SLC2A4	D008687
CTD	decreases(expression)	SLC2A4	D008687
CTD	increases(expression)	SLC2A4	D008687
CTD	increases(expression)	SLC2A4	D008687
CTD	decreases(reaction)	SLC47A1	D008687
CTD	increases(uptake)	SLC47A1	D008687
CTD	decreases(reaction)	SLC47A2	D008687
CTD	increases(uptake)	SLC47A2	D008687
CTD	increases(expression)	SOD2	D008687
CTD	affects(reaction)	SOD2	D008687
CTD	increases(expression)	TFAM	D008687
CTD	decreases(reaction)	TNF	D008687
CTD	increases(expression)	TNF	D008687
CTD	decreases(expression)	VEGFA	D008687

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