Tan Lab | DSigDB

Gene Set: D4 : CTD - Meclizine

Collection

D4 : CTD

Chemical Name

Meclizine ( From PubChem : MECLIZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
390.948 g/mol	0	2	5.4314	False(3/4)

Structure

InChI

InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3/t25-/m1/s1

InChIKey

Links

Gene (11 / 21)

⊖ Less

Source	Type	Unit	Gene	PMID	Other
CTD	affects(expression)		CLU		D008468
CTD	decreases(reaction)		CYP1A2		D008468
CTD	increases(activity)		CYP1A2		D008468
CTD	increases(expression)		CYP1A2		D008468
CTD	affects(expression)		GAL		D008468
CTD	affects(expression)		GAP43		D008468
CTD	decreases(reaction)		GSTP1		D008468
CTD	increases(metabolic processing)		GSTP1		D008468
CTD	affects(binding)		NCOA1		D008468
CTD	decreases(reaction)		NCOA1		D008468
CTD	affects(binding)		NR1I3		D008468
CTD	decreases(activity)		NR1I3		D008468
CTD	decreases(reaction)		NR1I3		D008468
CTD	increases(activity)		NR1I3		D008468
CTD	increases(expression)		NR1I3		D008468
CTD	increases(activity)		NR1I3		D008468
CTD	affects(expression)		RET		D008468
CTD	affects(expression)		TIMP1		D008468
ChEMBL	Inhibition	-	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-	CYP2D6	-	Target : CHEMBL289

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