Tan Lab | DSigDB

Gene Set: D4 : CTD - Mebendazole

Collection

D4 : CTD

Chemical Name

Mebendazole ( From PubChem : MEBENDAZOLE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
295.293 g/mol	2	5	3.0452	True

Structure

InChI

InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)

InChIKey

OPXLLQIJSORQAM-UHFFFAOYSA-N

Links

Gene (25 / 45)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			BAX		D008463
CTD	decreases(reaction)			BAX		D008463
CTD	increases(phosphorylation)			BAX		D008463
CTD	affects(response to substance)			BCL2		D008463
CTD	increases(phosphorylation)			BCL2		D008463
CTD	affects(binding)			BCL2		D008463
CTD	decreases(reaction)			BCL2		D008463
CTD	increases(expression)			CCL2		D008463
CTD	increases(expression)			CXCL8		D008463
CTD	increases(expression)			CXCL8		D008463
CTD	increases(secretion)			CXCL8		D008463
CTD	decreases(reaction)			CXCL8		D008463
CTD	increases(expression)			CYP1A1		D008463
CTD	increases(expression)			CYP1A1		D008463
CTD	increases(expression)			CYP1A2		D008463
CTD	increases(expression)			FOS		D008463
CTD	decreases(reaction)			GSTP1		D008463
CTD	increases(metabolic processing)			GSTP1		D008463
CTD	increases(expression)			IL6R		D008463
CTD	increases(phosphorylation)			MAPK1		D008463
CTD	increases(phosphorylation)			MAPK3		D008463
CTD	increases(phosphorylation)			MAPK8		D008463
CTD	increases(phosphorylation)			MAPK9		D008463
CTD	decreases(expression)			MAPT		D008463
CTD	increases(expression)			TNF		D008463
CTD	increases(secretion)			TNF		D008463
CTD	decreases(reaction)			TNF		D008463
CTD	increases(expression)			VEGFA		D008463
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	3.879	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.522	AHR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.349	AR	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.286	GMNN	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.758	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.059	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.255	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.326	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.461	TDP1	-	GI(Protien) :
ChEMBL	AC50	nM	3981.070	CYP1A2	-	Target : CHEMBL3356

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