Tan Lab | DSigDB

Gene Set: D4 : CTD - Malathion

Collection

D4 : CTD

Chemical Name

Malathion ( From PubChem : MALATHION )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
330.358 g/mol	0	8	2.7724	True

Structure

InChI

InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3/t8-/m0/s1

InChIKey

JXSJBGJIGXNWCI-QMMMGPOBSA-N

Links

Gene (37 / 77)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			ACHE		D008294
CTD	decreases(activity)			ACHE		D008294
CTD	decreases(activity)			ACHE		D008294
CTD	decreases(activity)			ACHE		D008294
CTD	decreases(reaction)			ACHE		D008294
CTD	increases(expression)			AKR1C1		D008294
CTD	increases(expression)			AKR1C2		D008294
CTD	affects(binding)			AR		D008294
CTD	affects(cotreatment)			AR		D008294
CTD	decreases(reaction)			AR		D008294
CTD	increases(activity)			AR		D008294
CTD	decreases(activity)			AR		D008294
CTD	decreases(activity)			BCHE		D008294
CTD	decreases(activity)			BCHE		D008294
CTD	decreases(reaction)			BCHE		D008294
CTD	decreases(expression)			BUB1		D008294
CTD	affects(cotreatment)			CAT		D008294
CTD	decreases(reaction)			CAT		D008294
CTD	increases(activity)			CAT		D008294
CTD	decreases(expression)			CDC20		D008294
CTD	decreases(expression)			CENPF		D008294
CTD	affects(metabolic processing)			CYP1A2		D008294
CTD	increases(expression)			CYP1A2		D008294
CTD	increases(expression)			CYP2A6		D008294
CTD	affects(metabolic processing)			CYP2B6		D008294
CTD	increases(expression)			CYP2B6		D008294
CTD	increases(reaction)			CYP2B6		D008294
CTD	decreases(activity)			CYP2B6		D008294
CTD	increases(expression)			CYP2B6		D008294
CTD	decreases(reaction)			CYP2C9		D008294
CTD	increases(hydroxylation)			CYP2C9		D008294
CTD	decreases(activity)			CYP2C9		D008294
CTD	decreases(reaction)			CYP2E1		D008294
CTD	increases(hydroxylation)			CYP2E1		D008294
CTD	decreases(activity)			CYP2E1		D008294
CTD	affects(metabolic processing)			CYP3A4		D008294
CTD	affects(cotreatment)			CYP3A4		D008294
CTD	increases(expression)			CYP3A4		D008294
CTD	increases(expression)			CYP3A4		D008294
CTD	affects(metabolic processing)			CYP3A5		D008294
CTD	affects(metabolic processing)			CYP3A7		D008294
CTD	increases(expression)			DVL1		D008294
CTD	increases(response to substance)			EHBP1		D008294
CTD	decreases(activity)			ESR1		D008294
CTD	affects(cotreatment)			HRAS		D008294
CTD	increases(expression)			HRAS		D008294
CTD	increases(expression)			HRAS		D008294
CTD	increases(expression)			HSPB2		D008294
CTD	affects(cotreatment)			MCM2		D008294
CTD	increases(expression)			MCM2		D008294
CTD	increases(expression)			NR1I3		D008294
CTD	decreases(reaction)			PCNA		D008294
CTD	increases(expression)			PCNA		D008294
CTD	decreases(expression)			PLAT		D008294
CTD	decreases(expression)			RFC3		D008294
CTD	decreases(reaction)			SLC22A2		D008294
CTD	increases(uptake)			SLC22A2		D008294
CTD	decreases(reaction)			SLC22A6		D008294
CTD	increases(uptake)			SLC22A6		D008294
CTD	decreases(reaction)			TP53		D008294
CTD	increases(expression)			TP53		D008294
CTD	increases(expression)			TP53		D008294
CTD	increases(expression)			TP53		D008294
CTD	affects(cotreatment)			TP53I3		D008294
CTD	increases(expression)			TP53I3		D008294
CTD	decreases(expression)			TYMS		D008294
PubChem	Potency-Replicate_1	uM	30.638	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	32.924	AHR	-	GI(Protien) :
PubChem	Potency	uM	1.000	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.859	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	29.767	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	48.558	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.022	TDP1	-	GI(Protien) :
PubChem	Potency	uM	4.328	TDP1	-	GI(Protien) :
PubChem	Potency	uM	28.184	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	1000.000	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159

Download gene sets

gmt, text, Detailed text