Tan Lab | DSigDB

Gene Set: D4 : CTD - Levodopa

Collection

D4 : CTD

Chemical Name

Levodopa ( From PubChem : LEVODOPA )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
197.188 g/mol	4	5	0.7525	True

Structure

InChI

InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

InChIKey

WTDRDQBEARUVNC-LURJTMIESA-N

Links

Gene (31 / 64)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(secretion)			AVP		D007980
CTD	increases(activity)			CASP3		D007980
CTD	affects(response to substance)			CASP3		D007980
CTD	affects(response to substance)			COMT		D007980
CTD	affects(response to substance)			COMT		D007980
CTD	increases(methylation)			COMT		D007980
CTD	decreases(activity)			COMT		D007980
CTD	decreases(reaction)			COMT		D007980
CTD	increases(abundance)			COMT		D007980
CTD	decreases(activity)			COMT		D007980
CTD	increases(abundance)			COMT		D007980
CTD	decreases(activity)			DBH		D007980
CTD	increases(response to substance)			DDC		D007980
CTD	affects(cotreatment)			DDC		D007980
CTD	decreases(abundance)			DDC		D007980
CTD	increases(abundance)			DDC		D007980
CTD	increases(expression)			GH1		D007980
CTD	increases(activity)			MAP3K5		D007980
CTD	affects(response to substance)			MAP3K5		D007980
CTD	decreases(expression)			PRL		D007980
CTD	affects(response to substance)			SOD1		D007980
CTD	decreases(expression)			TSHB		D007980
PubChem	Ratio Potency (uM)	uM	2.788	AR	-	GI(Protien) :
PubChem	Potency	uM	1.358	BLM	-	GI(Protien) :
PubChem	Potency	uM	19.953	CBX1	-	GI(Protien) :
PubChem	Potency	uM	31.623	CBX1	-	GI(Protien) :
PubChem	Potency	uM	8.200	DRD1	-	GI(Protien) :
PubChem	Potency	uM	7.943	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	19.953	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	3.769	FEN1	-	GI(Protien) :
PubChem	Potency	uM	3.769	FEN1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	None	uM		MBD2	-	GI(Protien) :
PubChem	None	uM		MBD2	-	GI(Protien) :
PubChem	Potency	uM	7.519	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	7.569	POLH	-	GI(Protien) :
PubChem	Potency	uM	31.623	POLH	-	GI(Protien) :
PubChem	Potency	uM	3.359	POLI	-	GI(Protien) :
PubChem	Potency	uM	22.387	POLI	-	GI(Protien) :
PubChem	Potency	uM	1.000	POLK	-	GI(Protien) :
PubChem	Potency	uM	11.917	POLK	-	GI(Protien) :
PubChem	Potency	uM	22.387	POLK	-	GI(Protien) :
PubChem	IC50	uM	0.526	PSIP1	-	GI(Protien) :
PubChem	IC50	uM	0.662	PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
PubChem	None	uM		UHRF1	-	GI(Protien) :
PubChem	Potency	uM	4.294	WRN	-	GI(Protien) :
PubChem	Potency	uM	6.702	WRN	-	GI(Protien) :
ChEMBL	Potency	nM	1995.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	31622.800	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	19952.600	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	7943.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3768.600	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	3981.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	316.200	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	39810.700	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	12589.300	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	7519.300	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	12589.300	RECQL	-	Target : CHEMBL1293236

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