Tan Lab | DSigDB

Gene Set: D4 : CTD - Chlordecone

Collection

D4 : CTD

Chemical Name

Chlordecone ( From PubChem : CHLORDECONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
490.636 g/mol	0	1	4.6182	True

Structure

InChI

InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20/t2-,3+,4-,5+,6+,7-,8+,9-

InChIKey

LHHGDZSESBACKH-RCJZDJILSA-N

Links

Gene (42 / 97)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB1		D007631
CTD	decreases(activity)			ABCC2		D007631
CTD	decreases(activity)			ABCG2		D007631
CTD	increases(reduction)			AKR1C4		D007631
CTD	affects(binding)			ALB		D007631
CTD	affects(binding)			AR		D007631
CTD	affects(binding)			AR		D007631
CTD	decreases(reaction)			AR		D007631
CTD	increases(activity)			AR		D007631
CTD	decreases(expression)			B3GALT5		D007631
CTD	affects(binding)			CDH1		D007631
CTD	decreases(reaction)			CDH1		D007631
CTD	decreases(expression)			CDH1		D007631
CTD	decreases(expression)			CTNNB1		D007631
CTD	increases(expression)			CYP2B6		D007631
CTD	increases(expression)			CYP3A4		D007631
CTD	affects(binding)			ESR1		D007631
CTD	increases(activity)			ESR1		D007631
CTD	affects(binding)			ESR1		D007631
CTD	affects(binding)			ESR1		D007631
CTD	decreases(reaction)			ESR1		D007631
CTD	increases(activity)			ESR1		D007631
CTD	decreases(reaction)			ESR1		D007631
CTD	increases(expression)			ESR1		D007631
CTD	affects(binding)			ESR2		D007631
CTD	decreases(activity)			ESR2		D007631
CTD	affects(binding)			ESR2		D007631
CTD	affects(binding)			ESR2		D007631
CTD	decreases(reaction)			ESR2		D007631
CTD	affects(binding)			GPER1		D007631
CTD	increases(activity)			GPER1		D007631
CTD	affects(binding)			JUP		D007631
CTD	decreases(reaction)			JUP		D007631
CTD	affects(binding)			NR1I2		D007631
CTD	increases(activity)			NR1I2		D007631
CTD	increases(activity)			NR1I2		D007631
CTD	affects(binding)			PGR		D007631
CTD	decreases(reaction)			PGR		D007631
CTD	decreases(expression)			POU5F1		D007631
CTD	increases(expression)			WISP2		D007631
CTD	decreases(reaction)			WISP2		D007631
PubChem	None	uM		ADAM10	-	GI(Protien) :
PubChem	None	uM		ADAM17	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.515	AR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	60.137	AR	-	GI(Protien) :
PubChem	Potency	uM	39.811	ATXN2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.862	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	52.164	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.382	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	6.298	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.804	ESR1	-	GI(Protien) :
PubChem	Potency	uM	7.943	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	18.691	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.515	ESR1	-	GI(Protien) :
PubChem	Potency	uM	28.184	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	32.913	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	52.644	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	56.843	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	64.227	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	65.671	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	65.671	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	67.475	ESR1	-	GI(Protien) :
PubChem	None	uM		FASN	-	GI(Protien) :
PubChem	Potency	uM	4.467	GLP1R	-	GI(Protien) :
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	None	uM		HSD17B4	-	GI(Protien) :
PubChem	AC50_uM	uM	2.685	HSP90AA1	-	GI(Protien) :
PubChem	Potency	uM	17.783	KCNH2		GI(Protien) :
PubChem	Potency	uM	17.783	KCNH2		GI(Protien) :
PubChem	Potency	uM	28.184	KCNH2		GI(Protien) :
PubChem	Potency	uM	28.184	KCNH2		GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.408	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	16.949	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.849	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	39.811	NR3C1	-	GI(Protien) :
PubChem	None	uM		PECR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	55.626	PPARD	-	GI(Protien) :
PubChem	Potency	uM	44.668	PPARG	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
PubChem	Potency	uM	39.811	VDR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.048	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	CYP3A4	-	Target : CHEMBL340

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