Tan Lab | DSigDB

Gene Set: D4 : CTD - Isoproterenol

Collection

D4 : CTD

Chemical Name

Isoproterenol ( From PubChem : ISOPROTERENOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
211.258 g/mol	4	4	1.5201	True

Structure

InChI

InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3/t11-/m0/s1

InChIKey

JWZZKOKVBUJMES-NSHDSACASA-N

Links

Gene (79 / 206)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ABCB4		D007545
CTD	decreases(expression)			ABCC3		D007545
CTD	affects(response to substance)			ADRB1		D007545
CTD	decreases(reaction)			ADRB1		D007545
CTD	increases(activity)			ADRB1		D007545
CTD	affects(binding)			ADRB1		D007545
CTD	increases(activity)			ADRB1		D007545
CTD	affects(binding)			ADRB1		D007545
CTD	increases(abundance)			ADRB1		D007545
CTD	increases(activity)			ADRB1		D007545
CTD	affects(binding)			ADRB1		D007545
CTD	decreases(reaction)			ADRB1		D007545
CTD	affects(binding)			ADRB1		D007545
CTD	decreases(reaction)			ADRB1		D007545
CTD	affects(binding)			ADRB1		D007545
CTD	increases(reaction)			ADRB1		D007545
CTD	increases(abundance)			ADRB1		D007545
CTD	increases(uptake)			ADRB1		D007545
CTD	increases(phosphorylation)			ADRB1		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	increases(reaction)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	decreases(reaction)			ADRB2		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	increases(abundance)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	increases(reaction)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	decreases(reaction)			ADRB2		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	increases(phosphorylation)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	increases(abundance)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	increases(phosphorylation)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	decreases(reaction)			ADRB2		D007545
CTD	increases(reaction)			ADRB2		D007545
CTD	increases(expression)			ADRB2		D007545
CTD	increases(uptake)			ADRB2		D007545
CTD	affects(binding)			ADRB2		D007545
CTD	decreases(reaction)			ADRB2		D007545
CTD	decreases(response to substance)			ADRB2		D007545
CTD	increases(activity)			ADRB2		D007545
CTD	affects(binding)			ADRB3		D007545
CTD	increases(activity)			ADRB3		D007545
CTD	affects(binding)			ADRB3		D007545
CTD	increases(abundance)			ADRB3		D007545
CTD	increases(activity)			ADRB3		D007545
CTD	decreases(reaction)			ADRB3		D007545
CTD	increases(activity)			ADRB3		D007545
CTD	decreases(reaction)			ADRB3		D007545
CTD	increases(expression)			ADRBK1		D007545
CTD	increases(expression)			AGT		D007545
CTD	decreases(reaction)			AGT		D007545
CTD	increases(expression)			AHR		D007545
CTD	increases(expression)			ALPP		D007545
CTD	increases(reaction)			ALPP		D007545
CTD	decreases(reaction)			ALPP		D007545
CTD	increases(expression)			APAF1		D007545
CTD	decreases(expression)			ARNT2		D007545
CTD	affects(binding)			ARRB1		D007545
CTD	increases(reaction)			ARRB1		D007545
CTD	increases(phosphorylation)			ARRB2		D007545
CTD	increases(reaction)			ARRB2		D007545
CTD	affects(localization)			ARRB2		D007545
CTD	affects(binding)			ARRB2		D007545
CTD	increases(reaction)			ARRB2		D007545
CTD	affects(binding)			ARRB2		D007545
CTD	decreases(reaction)			ARRB2		D007545
CTD	decreases(expression)			BAK1		D007545
CTD	decreases(expression)			BAX		D007545
CTD	decreases(expression)			BCL2L1		D007545
CTD	increases(expression)			BCL2L11		D007545
CTD	decreases(expression)			C3		D007545
CTD	decreases(expression)			CASP1		D007545
CTD	increases(expression)			CASP1		D007545
CTD	decreases(reaction)			CASP3		D007545
CTD	increases(activity)			CASP3		D007545
CTD	increases(cleavage)			CASP3		D007545
CTD	decreases(reaction)			CASP7		D007545
CTD	increases(activity)			CASP7		D007545
CTD	increases(cleavage)			CASP7		D007545
CTD	decreases(secretion)			CCL17		D007545
CTD	decreases(reaction)			CCL3		D007545
CTD	increases(expression)			CCL3		D007545
CTD	increases(expression)			CCL3		D007545
CTD	decreases(expression)			CCL7		D007545
CTD	increases(activity)			CFTR		D007545
CTD	increases(reaction)			CFTR		D007545
CTD	affects(cotreatment)			CFTR		D007545
CTD	increases(activity)			CFTR		D007545
CTD	increases(activity)			CFTR		D007545
CTD	increases(methylation)			COMT		D007545
CTD	increases(expression)			CXCL8		D007545
CTD	increases(reaction)			CXCL8		D007545
CTD	increases(expression)			CXCL8		D007545
CTD	increases(reaction)			CXCL8		D007545
CTD	decreases(expression)			CYP1A1		D007545
CTD	decreases(reaction)			CYP1A2		D007545
CTD	increases(activity)			CYP1A2		D007545
CTD	increases(reaction)			EGFR		D007545
CTD	increases(uptake)			EGFR		D007545
CTD	decreases(expression)			FHL1		D007545
CTD	decreases(expression)			FN1		D007545
CTD	decreases(expression)			HIF1AN		D007545
CTD	increases(expression)			HIF3A		D007545
CTD	increases(expression)			HMOX1		D007545
CTD	decreases(reaction)			HMOX1		D007545
CTD	decreases(expression)			HSPA1L		D007545
CTD	increases(expression)			HSPA1L		D007545
CTD	increases(expression)			HSPA2		D007545
CTD	decreases(expression)			HSPA5		D007545
CTD	decreases(expression)			HSPA8		D007545
CTD	decreases(secretion)			IFNG		D007545
CTD	increases(expression)			IL12B		D007545
CTD	decreases(expression)			IL1A		D007545
CTD	increases(expression)			IL1A		D007545
CTD	increases(expression)			IL1B		D007545
CTD	affects(response to substance)			IL1RN		D007545
CTD	decreases(expression)			IL4		D007545
CTD	increases(expression)			IL4		D007545
CTD	affects(response to substance)			IL5RA		D007545
CTD	increases(expression)			IL6		D007545
CTD	increases(reaction)			IL6		D007545
CTD	decreases(expression)			IL6		D007545
CTD	increases(expression)			IL6		D007545
CTD	increases(expression)			IL7		D007545
CTD	decreases(reaction)			ITGAM		D007545
CTD	increases(expression)			ITGAM		D007545
CTD	increases(reaction)			ITGAM		D007545
CTD	affects(binding)			KCNE1		D007545
CTD	increases(activity)			KCNE1		D007545
CTD	decreases(reaction)			KCNE1		D007545
CTD	affects(binding)			KCNQ1		D007545
CTD	increases(activity)			KCNQ1		D007545
CTD	decreases(reaction)			KCNQ1		D007545
CTD	decreases(secretion)			LEP		D007545
CTD	decreases(reaction)			LEP		D007545
CTD	increases(phosphorylation)			MAPK1		D007545
CTD	increases(reaction)			MAPK1		D007545
CTD	affects(binding)			MAPK1		D007545
CTD	affects(binding)			MAPK1		D007545
CTD	increases(activity)			MAPK1		D007545
CTD	increases(phosphorylation)			MAPK1		D007545
CTD	decreases(phosphorylation)			MAPK1		D007545
CTD	decreases(reaction)			MAPK1		D007545
CTD	increases(phosphorylation)			MAPK3		D007545
CTD	increases(reaction)			MAPK3		D007545
CTD	affects(binding)			MAPK3		D007545
CTD	affects(binding)			MAPK3		D007545
CTD	increases(activity)			MAPK3		D007545
CTD	increases(phosphorylation)			MAPK3		D007545
CTD	decreases(phosphorylation)			MAPK3		D007545
CTD	decreases(reaction)			MAPK3		D007545
CTD	increases(expression)			MMP9		D007545
CTD	decreases(reaction)			MMP9		D007545
CTD	affects(cotreatment)			MYBPC3		D007545
CTD	increases(response to substance)			MYBPC3		D007545
CTD	decreases(expression)			NOS2		D007545
CTD	increases(expression)			PMAIP1		D007545
CTD	decreases(expression)			REG3G		D007545
CTD	increases(activity)			REN		D007545
CTD	increases(expression)			REN		D007545
CTD	decreases(reaction)			REN		D007545
CTD	decreases(reaction)			RYR2		D007545
CTD	increases(phosphorylation)			RYR2		D007545
CTD	decreases(reaction)			SELE		D007545
CTD	increases(secretion)			SELE		D007545
CTD	decreases(reaction)			SELL		D007545
CTD	increases(reaction)			SELL		D007545
CTD	increases(secretion)			SELL		D007545
CTD	decreases(expression)			SFN		D007545
CTD	decreases(expression)			TFRC		D007545
CTD	decreases(expression)			TGFB1		D007545
CTD	decreases(expression)			TIMP1		D007545
CTD	increases(expression)			TIMP3		D007545
CTD	decreases(expression)			TIMP4		D007545
CTD	decreases(reaction)			TNF		D007545
CTD	increases(expression)			TNF		D007545
CTD	decreases(reaction)			TNF		D007545
CTD	increases(secretion)			TNF		D007545
CTD	decreases(expression)			TNF		D007545
CTD	increases(expression)			TNF		D007545
CTD	decreases(expression)			TNFRSF1A		D007545
CTD	decreases(expression)			TP53		D007545
CTD	increases(expression)			TP53		D007545
CTD	decreases(expression)			UCP3		D007545
CTD	increases(expression)			UCP3		D007545
CTD	decreases(expression)			VEGFA		D007545
CTD	increases(expression)			VEGFA		D007545
PubChem	Potency	uM	0.011	CBX1	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	14.125	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	13.092	MTOR	-	GI(Protien) :
PubChem	Potency	uM	79.433	VDR	-	GI(Protien) :
ChEMBL	Inhibition	-		ADRB2	-	Target : CHEMBL210
ChEMBL	Activity	-		ADRB2	-	Target : CHEMBL210
ChEMBL	Potency	nM	10.600	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	14125.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	13091.800	MTOR	-	Target : CHEMBL2842

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