Tan Lab | DSigDB

Gene Set: D4 : CTD - Isoniazid

Collection

D4 : CTD

Chemical Name

Isoniazid ( From PubChem : ISONIAZID )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
137.139 g/mol	2	4	0.7763	True

Structure

InChI

InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)

InChIKey

QRXWMOHMRWLFEY-UHFFFAOYSA-N

Links

Gene (14 / 37)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			C10ORF10		D007538
CTD	decreases(activity)			CYP2C8		D007538
CTD	decreases(reaction)			CYP2C8		D007538
CTD	affects(response to substance)			CYP2E1		D007538
CTD	affects(response to substance)			CYP2E1		D007538
CTD	increases(metabolic processing)			CYP2E1		D007538
CTD	increases(expression)			CYP2E1		D007538
CTD	increases(response to substance)			CYP3A4		D007538
CTD	decreases(activity)			CYP3A4		D007538
CTD	affects(cotreatment)			GSTT1		D007538
CTD	affects(response to substance)			GSTT1		D007538
CTD	affects(cotreatment)			GSTT1		D007538
CTD	increases(response to substance)			GSTT1		D007538
CTD	increases(expression)			INHBE		D007538
CTD	affects(response to substance)			NAT2		D007538
CTD	affects(metabolic processing)			NAT2		D007538
CTD	affects(metabolic processing)			NAT2		D007538
CTD	increases(acetylation)			NAT2		D007538
CTD	increases(acetylation)			NAT2		D007538
CTD	increases(metabolic processing)			NAT2		D007538
CTD	increases(expression)			NUPR1		D007538
CTD	increases(expression)			PLOD2		D007538
CTD	decreases(expression)			PPARG		D007538
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	0.573	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	7.942	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.333	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	27.389	AHR	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	3981.100	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	3981.070	CYP3A4	-	Target : CHEMBL340

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