Tan Lab | DSigDB

Gene Set: D4 : CTD - Clioquinol

Collection

D4 : CTD

Chemical Name

Clioquinol ( From PubChem : CLIOQUINOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
305.5 g/mol	1	2	3.1984	True

Structure

InChI

InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChIKey

QCDFBFJGMNKBDO-UHFFFAOYSA-N

Links

Gene (82 / 190)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			AGO2		D007464
CTD	decreases(expression)			AGO2		D007464
CTD	decreases(expression)			AK1		D007464
CTD	affects(cotreatment)			AKT1		D007464
CTD	decreases(reaction)			AKT1		D007464
CTD	increases(phosphorylation)			AKT1		D007464
CTD	affects(binding)			APP		D007464
CTD	decreases(reaction)			APP		D007464
CTD	increases(degradation)			APP		D007464
CTD	affects(cotreatment)			APP		D007464
CTD	decreases(expression)			APP		D007464
CTD	decreases(reaction)			APP		D007464
CTD	increases(secretion)			APP		D007464
CTD	affects(binding)			AR		D007464
CTD	decreases(expression)			AR		D007464
CTD	increases(phosphorylation)			ATM		D007464
CTD	decreases(expression)			BNIP3L		D007464
CTD	decreases(reaction)			CASP3		D007464
CTD	increases(activity)			CASP3		D007464
CTD	increases(cleavage)			CASP3		D007464
CTD	increases(expression)			CDKN1A		D007464
CTD	affects(cotreatment)			DCP1B		D007464
CTD	decreases(expression)			DCP1B		D007464
CTD	affects(cotreatment)			DICER1		D007464
CTD	decreases(expression)			DICER1		D007464
CTD	affects(cotreatment)			DROSHA		D007464
CTD	affects(expression)			DROSHA		D007464
CTD	affects(binding)			EGFR		D007464
CTD	decreases(reaction)			EGFR		D007464
CTD	increases(phosphorylation)			EGFR		D007464
CTD	decreases(activity)			EGFR		D007464
CTD	decreases(phosphorylation)			EGFR		D007464
CTD	increases(activity)			EGFR		D007464
CTD	affects(cotreatment)			EGFR		D007464
CTD	increases(expression)			EGFR		D007464
CTD	increases(reaction)			EGFR		D007464
CTD	decreases(expression)			EGLN1		D007464
CTD	decreases(expression)			EGLN2		D007464
CTD	increases(expression)			EGR1		D007464
CTD	affects(cotreatment)			EIF4E		D007464
CTD	increases(expression)			EIF4E		D007464
CTD	decreases(expression)			EPO		D007464
CTD	increases(expression)			EPO		D007464
CTD	affects(binding)			FN1		D007464
CTD	affects(cotreatment)			FN1		D007464
CTD	increases(expression)			FN1		D007464
CTD	increases(phosphorylation)			FN1		D007464
CTD	increases(reaction)			FN1		D007464
CTD	increases(expression)			GADD45A		D007464
CTD	increases(phosphorylation)			H2AFX		D007464
CTD	decreases(reaction)			HIF1A		D007464
CTD	increases(hydroxylation)			HIF1A		D007464
CTD	decreases(hydroxylation)			HIF1A		D007464
CTD	decreases(ubiquitination)			HIF1A		D007464
CTD	increases(activity)			HIF1A		D007464
CTD	increases(expression)			HIF1A		D007464
CTD	affects(cotreatment)			HIF1A		D007464
CTD	decreases(reaction)			HIF1AN		D007464
CTD	increases(hydroxylation)			HIF1AN		D007464
CTD	decreases(activity)			HIF1AN		D007464
CTD	decreases(expression)			HIF3A		D007464
CTD	affects(binding)			ITGA2		D007464
CTD	increases(phosphorylation)			ITGA2		D007464
CTD	increases(reaction)			ITGA2		D007464
CTD	affects(binding)			ITGA5		D007464
CTD	increases(phosphorylation)			ITGA5		D007464
CTD	increases(reaction)			ITGA5		D007464
CTD	affects(cotreatment)			MAPK1		D007464
CTD	decreases(reaction)			MAPK1		D007464
CTD	increases(phosphorylation)			MAPK1		D007464
CTD	affects(binding)			MAPK1		D007464
CTD	decreases(reaction)			MAPK1		D007464
CTD	increases(phosphorylation)			MAPK1		D007464
CTD	decreases(activity)			MAPK1		D007464
CTD	decreases(phosphorylation)			MAPK1		D007464
CTD	increases(activity)			MAPK1		D007464
CTD	affects(binding)			MAPK3		D007464
CTD	decreases(reaction)			MAPK3		D007464
CTD	increases(phosphorylation)			MAPK3		D007464
CTD	affects(cotreatment)			MAPK3		D007464
CTD	decreases(reaction)			MAPK3		D007464
CTD	increases(phosphorylation)			MAPK3		D007464
CTD	decreases(activity)			MAPK3		D007464
CTD	decreases(phosphorylation)			MAPK3		D007464
CTD	increases(activity)			MAPK3		D007464
CTD	affects(cotreatment)			MAPK8		D007464
CTD	decreases(reaction)			MAPK8		D007464
CTD	increases(phosphorylation)			MAPK8		D007464
CTD	increases(expression)			MIF		D007464
CTD	affects(cotreatment)			MIR130A		D007464
CTD	decreases(expression)			MIR130A		D007464
CTD	affects(cotreatment)			MIR15A		D007464
CTD	decreases(expression)			MIR15A		D007464
CTD	affects(cotreatment)			MIR223		D007464
CTD	decreases(expression)			MIR223		D007464
CTD	affects(cotreatment)			MIR29A		D007464
CTD	decreases(expression)			MIR29A		D007464
CTD	affects(cotreatment)			MMP2		D007464
CTD	increases(activity)			MMP2		D007464
CTD	increases(expression)			MMP2		D007464
CTD	affects(cotreatment)			MMP3		D007464
CTD	increases(activity)			MMP3		D007464
CTD	increases(expression)			MMP3		D007464
CTD	decreases(expression)			P4HA2		D007464
CTD	increases(expression)			PGK1		D007464
CTD	affects(binding)			SRC		D007464
CTD	increases(activity)			SRC		D007464
CTD	increases(phosphorylation)			SRC		D007464
CTD	decreases(reaction)			SULT1A3		D007464
CTD	increases(sulfation)			SULT1A3		D007464
CTD	decreases(reaction)			TP53		D007464
CTD	increases(phosphorylation)			TP53		D007464
CTD	decreases(expression)			VEGFA		D007464
CTD	increases(expression)			VEGFA		D007464
CTD	increases(expression)			VEGFA		D007464
CTD	decreases(expression)			VOPP1		D007464
PubChem	Potency-Replicate_1	uM	0.944	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	5.108	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	29.424	AHR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.006	AHR	-	GI(Protien) :
PubChem	Potency	uM	25.119	ALDH1A1	-	GI(Protien) :
PubChem	IC50_CXCR6_Mean	uM		APLNR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	21.646	AR	-	GI(Protien) :
PubChem	Potency	uM	39.811	BAZ2B	-	GI(Protien) :
PubChem	None	uM		CASP1	-	GI(Protien) :
PubChem	None	uM		CCR6	-	GI(Protien) :
PubChem	IC50_CXCR6_Mean	uM		CCR6	-	GI(Protien) :
PubChem	None	uM		CXCR6	-	GI(Protien) :
PubChem	IC50_CXCR6_Mean	uM		CXCR6	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.250	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	3.981	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	35.481	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.710	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	28.726	ESR1	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	AC50_uM	uM	1.158	HSP90AA1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.691	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	10.000	HTT	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPK1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	5.956	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.669	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	26.603	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
PubChem	EC50	uM		NOD2	-	GI(Protien) :
PubChem	Potency	uM	39.811	NR1H4	-	GI(Protien) :
PubChem	Potency	uM	28.184	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	IC50	uM	5.790	OPRK1	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	None	uM		RBBP8	-	GI(Protien) :
PubChem	None	uM		SIX1	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	Potency	uM	15.849	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
PubChem	Potency	uM	21.136	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.109	TDP1	-	GI(Protien) :
PubChem	None	uM		TNF	-	GI(Protien) :
PubChem	Potency	uM	7.943	TP53	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.695	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	25118.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	39810.700	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	AC50	nM	31.620	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	3981.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	35481.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10000.000	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	79432.800	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	14125.400	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	12589.300	MAPK1	-	Target : CHEMBL4040
ChEMBL	IC50	nM	5790.000	OPRK1	-	Target : CHEMBL237
ChEMBL	Potency	nM	7943.300	TP53	-	Target : CHEMBL4096

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