Tan Lab | DSigDB

Gene Set: D4 : CTD - Hydroxyurea

Collection

D4 : CTD

Chemical Name

Hydroxyurea ( From PubChem : HYDROXYUREA )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
76.0547 g/mol	3	4	0.1351	True

Structure

InChI

InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

InChIKey

VSNHCAURESNICA-UHFFFAOYSA-N

Links

Gene (96 / 123)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			ALOX5		D006918
CTD	decreases(reaction)			ALOX5		D006918
CTD	decreases(activity)			ATR		D006918
CTD	increases(response to substance)			ATR		D006918
CTD	decreases(reaction)			ATR		D006918
CTD	increases(activity)			ATR		D006918
CTD	increases(phosphorylation)			ATR		D006918
CTD	increases(reaction)			ATR		D006918
CTD	decreases(expression)			ATXN1		D006918
CTD	increases(expression)			BAX		D006918
CTD	decreases(expression)			BLM		D006918
CTD	increases(expression)			BLM		D006918
CTD	decreases(expression)			BORA		D006918
CTD	increases(expression)			BTG2		D006918
CTD	decreases(expression)			BTG3		D006918
CTD	decreases(expression)			C7ORF26		D006918
CTD	increases(activity)			CASP3		D006918
CTD	increases(reaction)			CASP3		D006918
CTD	increases(cleavage)			CASP3		D006918
CTD	increases(reaction)			CASP3		D006918
CTD	increases(cleavage)			CASP3		D006918
CTD	decreases(expression)			CCDC51		D006918
CTD	increases(expression)			CCNA2		D006918
CTD	increases(expression)			CCNB1		D006918
CTD	increases(expression)			CCND1		D006918
CTD	increases(expression)			CCND2		D006918
CTD	increases(expression)			CCND3		D006918
CTD	increases(expression)			CCNE1		D006918
CTD	increases(expression)			CCNG1		D006918
CTD	decreases(expression)			CDCA8		D006918
CTD	decreases(reaction)			CDKN1A		D006918
CTD	increases(expression)			CDKN1A		D006918
CTD	increases(expression)			CDKN1A		D006918
CTD	increases(expression)			CDKN1A		D006918
CTD	affects(cotreatment)			CDKN1A		D006918
CTD	increases(expression)			CDKN1B		D006918
CTD	affects(cotreatment)			CDKN1B		D006918
CTD	increases(expression)			CDKN1B		D006918
CTD	decreases(methylation)			CDKN2A		D006918
CTD	decreases(reaction)			CDKN2A		D006918
CTD	increases(expression)			CDKN2A		D006918
CTD	decreases(reaction)			CHEK1		D006918
CTD	increases(activity)			CHEK1		D006918
CTD	increases(phosphorylation)			CHEK1		D006918
CTD	increases(reaction)			CHEK1		D006918
CTD	decreases(expression)			CKS2		D006918
CTD	decreases(expression)			CLN8		D006918
CTD	decreases(expression)			COA7		D006918
CTD	decreases(expression)			CPT2		D006918
CTD	increases(response to substance)			DCLRE1C		D006918
CTD	increases(expression)			DDB2		D006918
CTD	affects(response to substance)			DNMT1		D006918
CTD	decreases(expression)			E2F1		D006918
CTD	decreases(expression)			EDN3		D006918
CTD	increases(expression)			EPO		D006918
CTD	increases(expression)			FAS		D006918
CTD	decreases(expression)			FOXJ2		D006918
CTD	decreases(expression)			FTSJ2		D006918
CTD	decreases(expression)			FZD1		D006918
CTD	increases(expression)			GADD45A		D006918
CTD	increases(expression)			GDF15		D006918
CTD	decreases(expression)			GRPEL1		D006918
CTD	decreases(expression)			HBP1		D006918
CTD	decreases(expression)			HDAC2		D006918
CTD	increases(reaction)			HDAC2		D006918
CTD	increases(expression)			HSPA8		D006918
CTD	decreases(expression)			ISG20L2		D006918
CTD	decreases(expression)			KIF20A		D006918
CTD	decreases(expression)			KPNA2		D006918
CTD	decreases(methylation)			L1RE1		D006918
CTD	decreases(reaction)			L1RE1		D006918
CTD	decreases(expression)			LHX2		D006918
CTD	decreases(expression)			LRRC47		D006918
CTD	decreases(methylation)			MAGEA1		D006918
CTD	decreases(reaction)			MAGEA1		D006918
CTD	increases(expression)			MDM2		D006918
CTD	increases(expression)			MECOM		D006918
CTD	decreases(expression)			MPZL1		D006918
CTD	decreases(expression)			MSH6		D006918
CTD	increases(expression)			NFKB1		D006918
CTD	increases(expression)			NFKBIA		D006918
CTD	increases(expression)			PCNA		D006918
CTD	decreases(expression)			PELO		D006918
CTD	increases(expression)			PHLDA3		D006918
CTD	increases(expression)			PPM1D		D006918
CTD	decreases(expression)			PRC1		D006918
CTD	increases(expression)			PRKAB1		D006918
CTD	decreases(expression)			PSRC1		D006918
CTD	decreases(expression)			PUS3		D006918
CTD	decreases(expression)			RAP2B		D006918
CTD	increases(expression)			RGS16		D006918
CTD	decreases(expression)			RNF113A		D006918
CTD	increases(expression)			RRM2B		D006918
CTD	increases(expression)			RUNX1		D006918
CTD	increases(expression)			SESN1		D006918
CTD	increases(expression)			SGK1		D006918
CTD	decreases(expression)			SLBP		D006918
CTD	decreases(expression)			SLC1A5		D006918
CTD	increases(reaction)			SNCA		D006918
CTD	increases(response to substance)			SNCA		D006918
CTD	decreases(expression)			TFEC		D006918
CTD	decreases(expression)			TIPIN		D006918
CTD	decreases(expression)			TMEM185B		D006918
CTD	increases(secretion)			TNF		D006918
CTD	increases(expression)			TNFRSF10B		D006918
CTD	decreases(expression)			TOR1A		D006918
CTD	increases(expression)			TP53		D006918
CTD	affects(localization)			TPP2		D006918
CTD	increases(expression)			TRADD		D006918
CTD	increases(reaction)			TRADD		D006918
CTD	increases(expression)			TRIAP1		D006918
CTD	decreases(expression)			TRIM32		D006918
CTD	decreases(expression)			TRIM38		D006918
CTD	decreases(expression)			UBE2C		D006918
CTD	decreases(expression)			UTP3		D006918
CTD	increases(expression)			XPC		D006918
CTD	decreases(response to substance)			XRCC4		D006918
CTD	decreases(expression)			ZBED1		D006918
CTD	decreases(expression)			ZBTB24		D006918
CTD	decreases(expression)			ZNF232		D006918
CTD	decreases(expression)			ZNF45		D006918
CTD	decreases(expression)			ZNF544		D006918
PubChem	Potency	uM	8.912	GLS	-	GI(Protien) :

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