Tan Lab | DSigDB

Gene Set: D4 : CTD - triptolide

Collection

D4 : CTD

Chemical Name

triptolide ( From PubChem : AC1L1KON )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
360.401 g/mol	1	6	1.1031	True

Structure

InChI

InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3

InChIKey

Links

Gene (27 / 41)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			BIRC3		C001899
CTD	increases(activity)			CASP3		C001899
CTD	increases(cleavage)			CASP3		C001899
CTD	increases(activity)			CASP3		C001899
CTD	increases(activity)			CASP7		C001899
CTD	decreases(expression)			CD80		C001899
CTD	decreases(expression)			CD86		C001899
CTD	decreases(reaction)			CGB		C001899
CTD	increases(abundance)			CGB		C001899
CTD	decreases(reaction)			CXCL8		C001899
CTD	increases(secretion)			CXCL8		C001899
CTD	decreases(reaction)			CXCL8		C001899
CTD	increases(expression)			CXCL8		C001899
CTD	decreases(expression)			DUSP1		C001899
CTD	decreases(expression)			EZH2		C001899
CTD	decreases(response to substance)			HSPA1A		C001899
CTD	decreases(expression)			ICAM1		C001899
CTD	affects(binding)			IL12A		C001899
CTD	decreases(expression)			IL12A		C001899
CTD	affects(binding)			IL12B		C001899
CTD	decreases(expression)			IL12B		C001899
CTD	decreases(phosphorylation)			MAPK14		C001899
CTD	decreases(reaction)			MAPK14		C001899
CTD	increases(expression)			NR3C1		C001899
CTD	increases(phosphorylation)			NR3C1		C001899
CTD	increases(cleavage)			PARP1		C001899
CTD	decreases(expression)			SUV39H1		C001899
CTD	decreases(reaction)			TAC1		C001899
CTD	increases(expression)			TAC1		C001899
CTD	decreases(reaction)			TNF		C001899
CTD	increases(secretion)			TNF		C001899
CTD	affects(cotreatment)			XIAP		C001899
CTD	affects(expression)			XIAP		C001899
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
PubChem	None	uM		S1PR3	-	GI(Protien) :
PubChem	None	uM		S1PR4	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.121	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.153	TDP1	-	GI(Protien) :

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