Tan Lab | DSigDB

Gene Set: D4 : CTD - Haloperidol

Collection

D4 : CTD

Chemical Name

Haloperidol ( From PubChem : HALOPERIDOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
375.864 g/mol	1	3	4.3635	True

Structure

InChI

InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChIKey

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Links

Gene (51 / 111)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB1		D006220
CTD	decreases(response to substance)			ABCB1		D006220
CTD	decreases(activity)			ABCB1		D006220
CTD	decreases(expression)			ABCB1		D006220
CTD	decreases(reaction)			ABCC1		D006220
CTD	decreases(response to substance)			ABCC1		D006220
CTD	decreases(expression)			ABCC1		D006220
CTD	decreases(reaction)			ABCG2		D006220
CTD	increases(transport)			ABCG2		D006220
CTD	decreases(expression)			ASNS		D006220
CTD	increases(expression)			C10ORF10		D006220
CTD	decreases(expression)			CRH		D006220
CTD	affects(response to substance)			CYP2D6		D006220
CTD	increases(activity)			CYP3A4		D006220
CTD	increases(oxidation)			CYP3A4		D006220
CTD	decreases(reaction)			CYP3A4		D006220
CTD	increases(activity)			CYP3A5		D006220
CTD	increases(oxidation)			CYP3A5		D006220
CTD	decreases(reaction)			CYP3A5		D006220
CTD	affects(activity)			DRD1		D006220
CTD	affects(binding)			DRD1		D006220
CTD	affects(binding)			DRD2		D006220
CTD	affects(activity)			DRD2		D006220
CTD	affects(binding)			DRD2		D006220
CTD	increases(expression)			DRD2		D006220
CTD	decreases(reaction)			DRD2		D006220
CTD	affects(binding)			DRD3		D006220
CTD	affects(activity)			DRD4		D006220
CTD	increases(response to substance)			DTNBP1		D006220
CTD	affects(response to substance)			DTNBP1		D006220
CTD	increases(expression)			FASN		D006220
CTD	increases(expression)			FNDC4		D006220
CTD	increases(expression)			GDPD3		D006220
CTD	decreases(reaction)			GSTP1		D006220
CTD	decreases(response to substance)			GSTP1		D006220
CTD	decreases(expression)			GSTP1		D006220
CTD	increases(activity)			HMGCR		D006220
CTD	increases(abundance)			HMGCR		D006220
CTD	increases(expression)			HMGCR		D006220
CTD	increases(expression)			HMGCS1		D006220
CTD	affects(binding)			HTR2A		D006220
CTD	increases(expression)			INHBE		D006220
CTD	decreases(reaction)			KCNH2		D006220
CTD	increases(transport)			KCNH2		D006220
CTD	decreases(activity)			KCNH2		D006220
CTD	increases(expression)			LDLR		D006220
CTD	affects(binding)			MCHR1		D006220
CTD	increases(expression)			NR0B2		D006220
CTD	increases(expression)			NUPR1		D006220
CTD	affects(expression)			PRL		D006220
CTD	increases(expression)			PRL		D006220
CTD	increases(secretion)			PRL		D006220
CTD	increases(expression)			QKI		D006220
CTD	increases(expression)			SC5D		D006220
CTD	increases(expression)			SCD		D006220
CTD	increases(expression)			SERPINA3		D006220
CTD	affects(binding)			SLC18A2		D006220
CTD	decreases(reaction)			SLC22A2		D006220
CTD	increases(uptake)			SLC22A2		D006220
CTD	increases(expression)			SLC2A4		D006220
CTD	affects(response to substance)			SNAP25		D006220
CTD	increases(activity)			SREBF2		D006220
CTD	increases(cleavage)			SREBF2		D006220
CTD	decreases(expression)			TAGLN		D006220
CTD	increases(expression)			WIPI1		D006220
PubChem	AR Potency (uM)	uM	29.849	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	40.856	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.131	AR	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	0.447	DRD1	-	GI(Protien) :
PubChem	Potency	uM	22.387	DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	20.596	GMNN	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	0.251	KCNH2		GI(Protien) :
PubChem	Potency	uM	0.251	KCNH2		GI(Protien) :
PubChem	Potency	uM	23.281	MTOR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.943	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :
PubChem	Potency	uM	29.855	TDP1	-	GI(Protien) :
ChEMBL	AC50	nM	5011.870	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	5011.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	22387.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	446.700	DRD1	-	Target : CHEMBL2056
ChEMBL	Activity	-		DRD2	-	Target : CHEMBL217
ChEMBL	Potency	nM	23280.900	MTOR	-	Target : CHEMBL2842
ChEMBL	Activity	-		SIGMAR1	-	Target : CHEMBL287

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