Tan Lab | DSigDB

Gene Set: D4 : CTD - Griseofulvin

Collection

D4 : CTD

Chemical Name

Griseofulvin ( From PubChem : GRISEOFULVIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
352.766 g/mol	0	6	2.8103	True

Structure

InChI

InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1

InChIKey

DDUHZTYCFQRHIY-RBHXEPJQSA-N

Links

Gene (22 / 54)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			CASP3		D006118
CTD	increases(activity)			CASP9		D006118
CTD	affects(metabolic processing)			CYP1A2		D006118
CTD	increases(reaction)			CYP1A2		D006118
CTD	increases(expression)			CYP3A4		D006118
CTD	increases(expression)			GJA1		D006118
CTD	increases(localization)			GJA1		D006118
CTD	decreases(reaction)			IL1A		D006118
CTD	increases(expression)			IL1A		D006118
CTD	affects(binding)			KRT18		D006118
CTD	increases(reaction)			KRT18		D006118
CTD	increases(expression)			KRT18		D006118
CTD	decreases(response to substance)			KRT18		D006118
CTD	decreases(reaction)			SELE		D006118
CTD	increases(expression)			SELE		D006118
CTD	decreases(expression)			SELL		D006118
CTD	decreases(reaction)			TNF		D006118
CTD	increases(expression)			TNF		D006118
CTD	decreases(reaction)			TNF		D006118
CTD	increases(expression)			TNF		D006118
CTD	decreases(reaction)			TNF		D006118
CTD	increases(expression)			TNF		D006118
CTD	decreases(reaction)			VCAM1		D006118
CTD	increases(expression)			VCAM1		D006118
CTD	decreases(reaction)			VCAM1		D006118
CTD	increases(expression)			VCAM1		D006118
CTD	decreases(reaction)			VCAM1		D006118
CTD	increases(expression)			VCAM1		D006118
PubChem	Potency-Replicate_1	uM	6.917	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.694	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	8.708	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.145	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	15.679	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	18.996	AR	-	GI(Protien) :
PubChem	Potency	uM	31.623	AR	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	5.447	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.917	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	8.011	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	8.708	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.868	ESR1	-	GI(Protien) :
PubChem	None	uM		ITGA4	-	GI(Protien) :
PubChem	None	uM		NAE1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.494	PPARG	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	41.639	PPARG	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.547	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	16.789	TDP1	-	GI(Protien) :
PubChem	None	uM		UBE2M	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :

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