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Gene Set: D4 : CTD - Flutamide

Collection D4 : CTD
Chemical Name Flutamide ( From PubChem : FLUTAMIDE )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotNotApprovedApprovedNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
276.212 g/mol 1 2 3.8043 True
Structure
InChI InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
InChIKey MKXKFYHWDHIYRV-UHFFFAOYSA-N
Links

Gene (33 / 118)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDincreases(hydrolysis)AADAC
D005485
CTDincreases(activity)ABCB1
D005485
CTDincreases(expression)ABCB1
D005485
CTDincreases(reaction)ABCB1
D005485
CTDaffects(cotreatment)ABCG2
D005485
CTDdecreases(reaction)ABCG2
D005485
CTDincreases(expression)ABCG2
D005485
CTDdecreases(phosphorylation)AKT1
D005485
CTDdecreases(reaction)AKT1
D005485
CTDdecreases(reaction)AR
D005485
CTDincreases(activity)AR
D005485
CTDaffects(binding)AR
D005485
CTDdecreases(activity)AR
D005485
CTDaffects(binding)AR
D005485
CTDdecreases(activity)AR
D005485
CTDdecreases(expression)AR
D005485
CTDaffects(binding)AR
D005485
CTDincreases(activity)AR
D005485
CTDdecreases(reaction)AR
D005485
CTDincreases(activity)AR
D005485
CTDaffects(binding)AR
D005485
CTDdecreases(reaction)AR
D005485
CTDincreases(activity)AR
D005485
CTDdecreases(reaction)AR
D005485
CTDincreases(activity)AR
D005485
CTDdecreases(reaction)AR
D005485
CTDincreases(expression)AR
D005485
CTDaffects(binding)AR
D005485
CTDdecreases(reaction)AR
D005485
CTDincreases(activity)AR
D005485
CTDdecreases(activity)AR
D005485
CTDaffects(cotreatment)CHEK2
D005485
CTDdecreases(reaction)CHEK2
D005485
CTDincreases(phosphorylation)CHEK2
D005485
CTDaffects(localization)CTNNB1
D005485
CTDaffects(cotreatment)CYP1A2
D005485
CTDaffects(response to substance)CYP1A2
D005485
CTDaffects(cotreatment)CYP2C19
D005485
CTDaffects(response to substance)CYP2C19
D005485
CTDaffects(cotreatment)CYP2C9
D005485
CTDaffects(response to substance)CYP2C9
D005485
CTDaffects(cotreatment)CYP2D6
D005485
CTDaffects(response to substance)CYP2D6
D005485
CTDaffects(cotreatment)CYP3A4
D005485
CTDaffects(response to substance)CYP3A4
D005485
CTDincreases(activity)CYP3A4
D005485
CTDincreases(expression)CYP3A4
D005485
CTDdecreases(reaction)FGF2
D005485
CTDincreases(expression)FGF2
D005485
CTDaffects(cotreatment)FSHB
D005485
CTDdecreases(expression)FSHB
D005485
CTDdecreases(reaction)GAS6
D005485
CTDincreases(expression)GAS6
D005485
CTDdecreases(expression)GAS6
D005485
CTDdecreases(reaction)GREB1
D005485
CTDincreases(expression)GREB1
D005485
CTDdecreases(reaction)GSTP1
D005485
CTDincreases(metabolic processing)GSTP1
D005485
CTDdecreases(reaction)IGF1
D005485
CTDincreases(expression)IGF1
D005485
CTDdecreases(reaction)IGFBP2
D005485
CTDincreases(expression)IGFBP2
D005485
CTDdecreases(secretion)IGFBP3
D005485
CTDdecreases(reaction)KLK3
D005485
CTDincreases(expression)KLK3
D005485
CTDaffects(cotreatment)LHB
D005485
CTDdecreases(expression)LHB
D005485
CTDaffects(response to substance)NFE2L2
D005485
CTDaffects(binding)NKX3-1
D005485
CTDdecreases(activity)NKX3-1
D005485
CTDdecreases(expression)NKX3-1
D005485
CTDaffects(binding)NR1I2
D005485
CTDincreases(activity)NR1I2
D005485
CTDincreases(activity)NR1I2
D005485
CTDincreases(expression)NR1I2
D005485
CTDincreases(reaction)NR1I2
D005485
CTDdecreases(reaction)SCNN1A
D005485
CTDincreases(expression)SCNN1A
D005485
CTDdecreases(activity)SRD5A2
D005485
CTDdecreases(expression)TNFRSF11B
D005485
CTDdecreases(reaction)TNFRSF11B
D005485
PubChem NoneuMABCB1-GI(Protien) :
PubChem Potency-Replicate_1uM12.650AR-GI(Protien) :
PubChem Ratio Potency (uM)uM13.448AR-GI(Protien) :
PubChem AR Potency (uM)uM29.849AR-GI(Protien) :
PubChem Potency-Replicate_1uM29.849AR-GI(Protien) :
PubChem Potency-Replicate_1uM49.944AR-GI(Protien) :
PubChem Potency-Replicate_1uM61.131AR-GI(Protien) :
PubChem Potency-Replicate_1uM62.875CYP19A1-GI(Protien) :
PubChem NoneuMCYP19A1-GI(Protien) :
PubChem NoneuMCYP1A2-GI(Protien) :
PubChem NoneuMCYP1A2-GI(Protien) :
PubChem PotencyuM2.512EHMT2-GI(Protien) :
PubChem ER Potency (uM)uM27.644ESR1-GI(Protien) :
PubChem Potency-Replicate_1uM29.849ESR1-GI(Protien) :
PubChem Potency-Replicate_1uM48.966ESR1-GI(Protien) :
PubChem Potency-Replicate_1uM49.944ESR1-GI(Protien) :
PubChem Ratio Potency (uM)uM52.873ESR1-GI(Protien) :
PubChem ER Potency (uM)uM56.038ESR1-GI(Protien) :
PubChem NoneuMINS-GI(Protien) :
PubChem Potency-Replicate_1uM19.331NFE2L2-GI(Protien) :
PubChem Potency-Replicate_1uM23.708NFE2L2-GI(Protien) :
PubChem Ratio Potency (uM)uM26.601NFE2L2-GI(Protien) :
PubChem Ratio Potency (uM)uM35.721NFE2L2-GI(Protien) :
PubChem PotencyuM61.131NFE2L2-GI(Protien) :
PubChem PotencyuM66.824NFE2L2-GI(Protien) :
PubChem Potency-Replicate_1uM11.220NR1I2-GI(Protien) :
PubChem PotencyuM8.414TDP1-GI(Protien) :
PubChem PotencyuM9.200TDP1-GI(Protien) :
PubChem PotencyuM11.220TDP1-GI(Protien) :
PubChem PotencyuM11.582TDP1-GI(Protien) :
PubChem PotencyuM12.995TDP1-GI(Protien) :
PubChem PotencyuM13.336TDP1-GI(Protien) :
ChEMBLAC50nM316.230CYP1A2
-Target : CHEMBL3356
ChEMBLInhibition-CYP2C19
-Target : CHEMBL3622
ChEMBLInhibition-CYP2C9
-Target : CHEMBL3397
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
ChEMBLPotencynM2511.900EHMT2
-Target : CHEMBL6032
Download gene sets gmt, text, Detailed text
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