Tan Lab | DSigDB

Gene Set: D4 : CTD - Flupenthixol

Collection

D4 : CTD

Chemical Name

Flupenthixol ( From PubChem : FLUPENTIXOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
434.518 g/mol	1	4	4.4775	True

Structure

InChI

InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5-

InChIKey

Links

Gene (10 / 17)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB1		D005475
CTD	decreases(response to substance)			ABCB1		D005475
CTD	decreases(activity)			ABCB1		D005475
CTD	decreases(activity)			ABCB1		D005475
CTD	affects(binding)			DRD1		D005475
CTD	decreases(expression)			PTGS1		D005475
CTD	decreases(expression)			PTGS2		D005475
PubChem	Potency	uM	17.783	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	22.387	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	35.481	CBX1	-	GI(Protien) :
PubChem	Potency	uM	0.112	DRD1	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	9.441	TDP1	-	GI(Protien) :
PubChem	Potency	uM	56.234	USP1	-	GI(Protien) :
ChEMBL	Potency	nM	35481.300	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	112.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Activity	-		DRD2	-	Target : CHEMBL217

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