Tan Lab | DSigDB

Gene Set: D4 : CTD - Floxuridine

Collection

D4 : CTD

Chemical Name

Floxuridine ( From PubChem : FLOXURIDINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
246.192 g/mol	3	6	-1.6836	True

Structure

InChI

InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChIKey

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

Links

Gene (31 / 49)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(response to substance)			APEX1		D005467
CTD	decreases(response to substance)			APEX1		D005467
CTD	decreases(response to substance)			ATR		D005467
CTD	increases(activity)			CHEK1		D005467
CTD	increases(phosphorylation)			CHEK1		D005467
CTD	increases(activity)			CHEK2		D005467
CTD	increases(activity)			CHEK2		D005467
CTD	increases(phosphorylation)			CHEK2		D005467
CTD	decreases(reaction)			MLH1		D005467
CTD	decreases(response to substance)			MLH1		D005467
CTD	decreases(reaction)			MSH2		D005467
CTD	decreases(response to substance)			MSH2		D005467
CTD	affects(response to substance)			MTHFR		D005467
CTD	decreases(response to substance)			PARP1		D005467
CTD	decreases(response to substance)			TIMP3		D005467
CTD	affects(response to substance)			TIMP3		D005467
CTD	increases(expression)			TK1		D005467
CTD	increases(expression)			TP53		D005467
CTD	affects(response to substance)			TYMS		D005467
CTD	decreases(response to substance)			TYMS		D005467
CTD	increases(response to substance)			TYMS		D005467
CTD	affects(expression)			UNG		D005467
CTD	affects(stability)			UNG		D005467
CTD	increases(response to substance)			UNG		D005467
CTD	decreases(response to substance)			XRCC1		D005467
CTD	decreases(response to substance)			XRCC4		D005467
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency	uM	0.461	IDH1	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	EC50	uM		MMP14	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.335	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	Potency	uM	0.002	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.003	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.007	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.009	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.037	TDP1	-	GI(Protien) :
PubChem	Potency	uM	3.264	TDP1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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