Tan Lab | DSigDB

Gene Set: D4 : CTD - Fludrocortisone

Collection

D4 : CTD

Chemical Name

Fludrocortisone ( From PubChem : FLUDROCORTISONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
380.45 g/mol	3	5	1.8737	True

Structure

InChI

InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

InChIKey

AAXVEMMRQDVLJB-BULBTXNYSA-N

Links

Gene (11 / 27)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AR		D005438
CTD	increases(activity)			AR		D005438
CTD	affects(binding)			AR		D005438
CTD	decreases(expression)			CCL2		D005438
CTD	increases(expression)			CCL3		D005438
CTD	increases(expression)			CCL4		D005438
CTD	increases(expression)			KLK3		D005438
CTD	affects(binding)			NR3C1		D005438
CTD	increases(activity)			NR3C1		D005438
CTD	affects(binding)			NR3C2		D005438
CTD	decreases(abundance)			NR3C2		D005438
CTD	increases(activity)			NR3C2		D005438
CTD	decreases(expression)			NR3C2		D005438
CTD	affects(binding)			POMC		D005438
CTD	decreases(expression)			POMC		D005438
CTD	increases(activity)			POMC		D005438
CTD	decreases(expression)			VEGFA		D005438
PubChem	Ratio Potency (uM)	uM	0.016	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.019	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.021	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.053	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.060	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.731	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.043	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.043	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.045	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :

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