Tan Lab | DSigDB

Gene Set: D4 : CTD - Emodin

Collection

D4 : CTD

Chemical Name

Emodin ( From PubChem : EMODIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
270.237 g/mol	3	5	1.8872	True

Structure

InChI

InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3

InChIKey

RHMXXJGYXNZAPX-UHFFFAOYSA-N

Links

Gene (112 / 204)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ACTA1		D004642
CTD	affects(binding)			AHR		D004642
CTD	increases(activity)			AHR		D004642
CTD	affects(cotreatment)			AKT1		D004642
CTD	decreases(expression)			AKT1		D004642
CTD	decreases(reaction)			AKT1		D004642
CTD	increases(phosphorylation)			AKT1		D004642
CTD	decreases(expression)			AKT1		D004642
CTD	increases(expression)			ATM		D004642
CTD	increases(phosphorylation)			ATM		D004642
CTD	decreases(expression)			BAG5		D004642
CTD	decreases(expression)			BCL2		D004642
CTD	decreases(expression)			BFAR		D004642
CTD	decreases(expression)			BIRC5		D004642
CTD	decreases(expression)			CANX		D004642
CTD	increases(activity)			CASP3		D004642
CTD	increases(expression)			CASP3		D004642
CTD	decreases(expression)			CCNB2		D004642
CTD	decreases(expression)			CDK13		D004642
CTD	decreases(expression)			CDK4		D004642
CTD	decreases(expression)			CELSR3		D004642
CTD	affects(cotreatment)			COPS5		D004642
CTD	decreases(expression)			COPS5		D004642
CTD	decreases(expression)			CTSD		D004642
CTD	decreases(reaction)			CYP1A1		D004642
CTD	increases(expression)			CYP1A1		D004642
CTD	increases(expression)			CYP1A1		D004642
CTD	increases(expression)			CYP1A1		D004642
CTD	increases(expression)			CYP1B1		D004642
CTD	increases(expression)			CYP1B1		D004642
CTD	decreases(expression)			DHFR		D004642
CTD	increases(expression)			DNAJB1		D004642
CTD	increases(expression)			E2F5		D004642
CTD	increases(expression)			EI24		D004642
CTD	decreases(expression)			EIF2B1		D004642
CTD	increases(activity)			ESR1		D004642
CTD	increases(activity)			ESR2		D004642
CTD	increases(expression)			FOXO1		D004642
CTD	increases(expression)			GAS2		D004642
CTD	increases(expression)			GPX1		D004642
CTD	decreases(expression)			GSTM3		D004642
CTD	decreases(reaction)			GSTP1		D004642
CTD	increases(expression)			GSTP1		D004642
CTD	increases(expression)			H2AFX		D004642
CTD	affects(reaction)			H2AFX		D004642
CTD	decreases(expression)			HACD3		D004642
CTD	affects(cotreatment)			IFNA2		D004642
CTD	decreases(expression)			IFNA2		D004642
CTD	decreases(reaction)			IL6		D004642
CTD	increases(phosphorylation)			IL6		D004642
CTD	decreases(expression)			ITPR1		D004642
CTD	decreases(reaction)			JAK1		D004642
CTD	increases(phosphorylation)			JAK1		D004642
CTD	decreases(phosphorylation)			JAK1		D004642
CTD	decreases(reaction)			JAK2		D004642
CTD	increases(phosphorylation)			JAK2		D004642
CTD	decreases(phosphorylation)			JAK2		D004642
CTD	affects(cotreatment)			JUND		D004642
CTD	decreases(expression)			JUND		D004642
CTD	decreases(expression)			KRT19		D004642
CTD	decreases(expression)			MACF1		D004642
CTD	decreases(reaction)			MAPK14		D004642
CTD	increases(activity)			MAPK14		D004642
CTD	increases(phosphorylation)			MAPK14		D004642
CTD	increases(reaction)			MAPK14		D004642
CTD	decreases(expression)			MAPT		D004642
CTD	decreases(expression)			MCL1		D004642
CTD	increases(expression)			NFKBIA		D004642
CTD	increases(activity)			PARP1		D004642
CTD	decreases(expression)			PDCL		D004642
CTD	decreases(expression)			PECAM1		D004642
CTD	increases(expression)			PIK3C3		D004642
CTD	increases(expression)			PPM1D		D004642
CTD	increases(expression)			PRDX6		D004642
CTD	decreases(expression)			PRKCD		D004642
CTD	increases(expression)			PTPN6		D004642
CTD	decreases(activity)			PTPN6		D004642
CTD	decreases(phosphorylation)			PTPN6		D004642
CTD	decreases(reaction)			PTPN6		D004642
CTD	decreases(expression)			RAF1		D004642
CTD	decreases(expression)			RB1		D004642
CTD	increases(expression)			RCN2		D004642
CTD	decreases(expression)			RHOA		D004642
CTD	decreases(expression)			ROCK1		D004642
CTD	decreases(expression)			ROCK2		D004642
CTD	decreases(expression)			SAE1		D004642
CTD	decreases(reaction)			SERPINE1		D004642
CTD	increases(reaction)			SERPINE1		D004642
CTD	increases(secretion)			SERPINE1		D004642
CTD	decreases(phosphorylation)			SRC		D004642
CTD	increases(expression)			ST8SIA1		D004642
CTD	affects(localization)			STAT3		D004642
CTD	decreases(reaction)			STAT3		D004642
CTD	increases(phosphorylation)			STAT3		D004642
CTD	decreases(activity)			STAT3		D004642
CTD	decreases(phosphorylation)			STAT3		D004642
CTD	decreases(expression)			STIP1		D004642
CTD	increases(expression)			SUPT20H		D004642
CTD	decreases(expression)			TAOK3		D004642
CTD	decreases(expression)			TBCC		D004642
CTD	decreases(reaction)			TNF		D004642
CTD	increases(reaction)			TNF		D004642
CTD	increases(secretion)			TNF		D004642
CTD	decreases(reaction)			TNF		D004642
CTD	increases(expression)			TNF		D004642
CTD	decreases(reaction)			TOP2A		D004642
CTD	increases(hydrolysis)			TOP2A		D004642
CTD	increases(activity)			TOP2A		D004642
CTD	affects(reaction)			TOP2A		D004642
CTD	increases(expression)			TOP2A		D004642
CTD	increases(expression)			TRAF2		D004642
CTD	decreases(expression)			TUBB3		D004642
CTD	decreases(expression)			TXNL4B		D004642
CTD	decreases(expression)			TXNRD1		D004642
CTD	increases(glucuronidation)			UGT1A1		D004642
CTD	increases(glucuronidation)			UGT1A10		D004642
CTD	increases(glucuronidation)			UGT1A7		D004642
CTD	increases(glucuronidation)			UGT1A8		D004642
CTD	increases(glucuronidation)			UGT1A9		D004642
CTD	increases(metabolic processing)			UGT2B15		D004642
CTD	decreases(expression)			VDAC1		D004642
CTD	decreases(expression)			VEGFA		D004642
PubChem	Potency-Replicate_1	uM	5.974	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	8.438	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	14.221	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	34.376	AHR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AHR	-	GI(Protien) :
PubChem	Potency	uM	12.589	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	14.125	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	22.387	ALDH1A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.918	AR	-	GI(Protien) :
PubChem	None	uM		CASP3	-	GI(Protien) :
PubChem	Potency	uM	22.387	CBX1	-	GI(Protien) :
PubChem	Potency	uM	66.824	CXCL8	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.782	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	1.683	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	8.912	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.723	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	5.324	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.026	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.592	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.762	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.965	ESR1	-	GI(Protien) :
PubChem	Potency	uM	15.003	FEN1	-	GI(Protien) :
PubChem	Potency	uM	39.811	FEN1	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	Potency	uM	8.912	MAPT	-	GI(Protien) :
PubChem	Potency	uM	10.000	MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	Potency	uM	10.621	MPHOSPH8	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.229	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	9.688	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.461	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	18.834	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	11.220	POLB	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
PubChem	Potency	uM	21.136	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.589	THPO	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	22387.200	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	14125.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	35481.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	22387.200	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	7943.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	3981.100	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	7943.300	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	31622.800	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	12589.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	10000.000	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	8912.500	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1683.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15003.000	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	44668.400	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	8912.500	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	10000.000	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	10621.300	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Inhibition	-		PIK3CA	-	Target : CHEMBL4005
ChEMBL	Inhibition	-		PIK3CA	-	Target : CHEMBL4005
ChEMBL	Potency	nM	11220.200	POLB	-	Target : CHEMBL2392
ChEMBL	Inhibition	-		PTP4A3	-	Target : CHEMBL4162
ChEMBL	Potency	nM	12589.300	THPO	-	Target : CHEMBL1293256

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