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Gene Set: D4 : CTD - Dopamine

Collection D4 : CTD
Chemical Name Dopamine ( From PubChem : DOPAMINE )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotApprovedApprovedNotApprovedApprovedNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
153.178 g/mol 3 3 1.2993 True
Structure
InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
InChIKey VYFYYTLLBUKUHU-UHFFFAOYSA-N
Links

Gene (62 / 194)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDdecreases(reaction)AGT
D004298
CTDincreases(reaction)AGT
D004298
CTDincreases(secretion)AGT
D004298
CTDdecreases(expression)BAX
D004298
CTDincreases(expression)BBC3
D004298
CTDdecreases(expression)BCL2
D004298
CTDdecreases(reaction)BCL2
D004298
CTDincreases(expression)BNIP3
D004298
CTDdecreases(reaction)CASP3
D004298
CTDincreases(activity)CASP3
D004298
CTDincreases(cleavage)CASP3
D004298
CTDaffects(cotreatment)CASP3
D004298
CTDincreases(activity)CASP3
D004298
CTDincreases(activity)CASP3
D004298
CTDincreases(activity)CASP3
D004298
CTDincreases(cleavage)CASP3
D004298
CTDincreases(cleavage)CASP3
D004298
CTDdecreases(reaction)CASP3
D004298
CTDdecreases(reaction)CASP3
D004298
CTDdecreases(reaction)CASP7
D004298
CTDincreases(activity)CASP7
D004298
CTDincreases(cleavage)CASP7
D004298
CTDincreases(activity)CASP7
D004298
CTDdecreases(abundance)CAT
D004298
CTDdecreases(reaction)CAT
D004298
CTDdecreases(reaction)COMT
D004298
CTDincreases(methylation)COMT
D004298
CTDincreases(methylation)COMT
D004298
CTDdecreases(activity)COMT
D004298
CTDincreases(abundance)COMT
D004298
CTDdecreases(activity)COMT
D004298
CTDincreases(abundance)COMT
D004298
CTDdecreases(reaction)CYP1A1
D004298
CTDincreases(activity)CYP1A1
D004298
CTDdecreases(activity)CYP2D6
D004298
CTDdecreases(activity)CYP3A4
D004298
CTDaffects(localization)DRD1
D004298
CTDaffects(binding)DRD1
D004298
CTDincreases(activity)DRD1
D004298
CTDdecreases(reaction)DRD1
D004298
CTDaffects(binding)DRD2
D004298
CTDaffects(cotreatment)DRD2
D004298
CTDincreases(reaction)DRD2
D004298
CTDincreases(expression)F3
D004298
CTDincreases(reaction)F3
D004298
CTDaffects(cotreatment)FOS
D004298
CTDdecreases(reaction)FOS
D004298
CTDincreases(expression)FOS
D004298
CTDincreases(cleavage)GCLC
D004298
CTDincreases(reaction)GCLC
D004298
CTDdecreases(reaction)GDNF
D004298
CTDdecreases(secretion)GDNF
D004298
CTDdecreases(activity)GSTA1
D004298
CTDdecreases(activity)GSTM1
D004298
CTDdecreases(activity)GSTP1
D004298
CTDdecreases(reaction)HIF1A
D004298
CTDincreases(expression)HIF1A
D004298
CTDincreases(phosphorylation)HIF1A
D004298
CTDdecreases(abundance)HMOX1
D004298
CTDdecreases(reaction)HMOX1
D004298
CTDaffects(binding)HTR3A
D004298
CTDincreases(activity)HTR3A
D004298
CTDaffects(binding)HTR3B
D004298
CTDincreases(activity)HTR3B
D004298
CTDincreases(expression)INS
D004298
CTDincreases(reaction)INS
D004298
CTDincreases(secretion)INS
D004298
CTDincreases(phosphorylation)JUN
D004298
CTDdecreases(reaction)JUN
D004298
CTDaffects(cotreatment)LRRK2
D004298
CTDincreases(response to substance)LRRK2
D004298
CTDincreases(activity)MAPK1
D004298
CTDincreases(phosphorylation)MAPK1
D004298
CTDaffects(reaction)MAPK1
D004298
CTDincreases(activity)MAPK3
D004298
CTDincreases(phosphorylation)MAPK3
D004298
CTDaffects(reaction)MAPK3
D004298
CTDaffects(binding)MAPT
D004298
CTDincreases(reaction)MAPT
D004298
CTDdecreases(phosphorylation)MTOR
D004298
CTDdecreases(reaction)MTR
D004298
CTDincreases(activity)MTR
D004298
CTDincreases(reaction)MTR
D004298
CTDincreases(expression)PARK2
D004298
CTDdecreases(reaction)PARK2
D004298
CTDincreases(abundance)PARK2
D004298
CTDincreases(cleavage)PARK2
D004298
CTDincreases(phosphorylation)PARK2
D004298
CTDincreases(cleavage)PARP1
D004298
CTDincreases(reaction)PARP1
D004298
CTDincreases(cleavage)PARP1
D004298
CTDdecreases(reaction)PARP1
D004298
CTDincreases(cleavage)PARP1
D004298
CTDdecreases(reaction)PARP1
D004298
CTDincreases(cleavage)PARP1
D004298
CTDdecreases(expression)PRL
D004298
CTDdecreases(reaction)PRL
D004298
CTDaffects(reaction)RGS3
D004298
CTDincreases(activity)RGS3
D004298
CTDincreases(phosphorylation)RGS3
D004298
CTDdecreases(phosphorylation)RPS6KB1
D004298
CTDincreases(metabolic processing)SCT
D004298
CTDdecreases(reaction)SLC18A1
D004298
CTDincreases(uptake)SLC18A1
D004298
CTDaffects(binding)SLC18A2
D004298
CTDdecreases(activity)SLC18A2
D004298
CTDdecreases(reaction)SLC18A2
D004298
CTDincreases(uptake)SLC18A2
D004298
CTDdecreases(reaction)SLC22A16
D004298
CTDincreases(uptake)SLC22A16
D004298
CTDdecreases(reaction)SLC25A14
D004298
CTDincreases(expression)SLC25A14
D004298
CTDincreases(abundance)SLC25A14
D004298
CTDdecreases(response to substance)SLC25A14
D004298
CTDdecreases(reaction)SLC6A2
D004298
CTDincreases(activity)SLC6A2
D004298
CTDincreases(reaction)SLC6A2
D004298
CTDaffects(cotreatment)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(expression)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(export)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(uptake)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(uptake)SLC6A3
D004298
CTDaffects(localization)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(activity)SLC6A3
D004298
CTDincreases(reaction)SLC6A3
D004298
CTDaffects(cotreatment)SLC6A3
D004298
CTDincreases(response to substance)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(uptake)SLC6A3
D004298
CTDdecreases(reaction)SLC6A3
D004298
CTDincreases(uptake)SLC6A3
D004298
CTDincreases(response to substance)SLC6A3
D004298
CTDincreases(transport)SLC6A3
D004298
CTDincreases(uptake)SLC6A3
D004298
CTDdecreases(reaction)SLC6A4
D004298
CTDincreases(activity)SLC6A4
D004298
CTDincreases(reaction)SLC6A4
D004298
CTDincreases(response to substance)SNCA
D004298
CTDaffects(abundance)SNCA
D004298
CTDdecreases(reaction)SULT1A1
D004298
CTDincreases(sulfation)SULT1A1
D004298
CTDdecreases(reaction)SULT1A3
D004298
CTDincreases(sulfation)SULT1A3
D004298
CTDdecreases(reaction)SULT1A3
D004298
CTDincreases(sulfation)SULT1A3
D004298
CTDdecreases(reaction)SULT1A3
D004298
CTDincreases(sulfation)SULT1A3
D004298
CTDdecreases(reaction)SULT1A3
D004298
CTDincreases(sulfation)SULT1A3
D004298
CTDdecreases(reaction)SULT1A3
D004298
CTDincreases(sulfation)SULT1A3
D004298
CTDincreases(sulfation)SULT1A3
D004298
CTDdecreases(reaction)TAAR1
D004298
CTDincreases(activity)TAAR1
D004298
CTDincreases(reaction)TAAR1
D004298
CTDincreases(chemical synthesis)TH
D004298
CTDincreases(expression)TNF
D004298
CTDincreases(reaction)TNF
D004298
CTDdecreases(reaction)TNF
D004298
CTDdecreases(uptake)TNF
D004298
CTDincreases(secretion)TNF
D004298
CTDincreases(uptake)TNF
D004298
CTDincreases(expression)TP53
D004298
CTDincreases(phosphorylation)TP53
D004298
PubChem PotencyuM0.052DRD1-GI(Protien) :
PubChem PotencyuM0.100DRD1-GI(Protien) :
PubChem PotencyuM0.251DRD1-GI(Protien) :
PubChem PotencyuM8.912EHMT2-GI(Protien) :
PubChem PotencyuM0.844FEN1-GI(Protien) :
PubChem PotencyuM0.844FEN1-GI(Protien) :
PubChem PotencyuM10.000HIF1A-GI(Protien) :
PubChem PotencyuM1.062MPHOSPH8-GI(Protien) :
PubChem Potency-Replicate_1uM0.376NFE2L2-GI(Protien) :
PubChem Ratio Potency (uM)uM0.643NFE2L2-GI(Protien) :
PubChem PotencyuM4.109TDP1-GI(Protien) :
PubChem PotencyuM5.173TDP1-GI(Protien) :
PubChem PotencyuM12.589TP53-GI(Protien) :
ChEMBLActivity-ADRA2A
-Target : CHEMBL1867
ChEMBLPotencynM251.200DRD1
-Target : CHEMBL2056
ChEMBLPotencynM100.000DRD1
-Target : CHEMBL2056
ChEMBLPotencynM8912.500EHMT2
-Target : CHEMBL6032
ChEMBLPotencynM843.700FEN1
-Target : CHEMBL5027
ChEMBLPotencynM10000.000HIF1A
-Target : CHEMBL4261
ChEMBLPotencynM501.200HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM31622.800HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM15848.900KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM1062.100MPHOSPH8
-Target : CHEMBL1741210
ChEMBLPotencynM14125.400RECQL
-Target : CHEMBL1293236
ChEMBLPotencynM12589.300TP53
-Target : CHEMBL4096
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