Tan Lab | DSigDB

Gene Set: D4 : CTD - Disulfiram

Collection

D4 : CTD

Chemical Name

Disulfiram ( From PubChem : DISULFIRAM )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
296.539 g/mol	0	6	3.6212	True

Structure

InChI

InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

InChIKey

AUZONCFQVSMFAP-UHFFFAOYSA-N

Links

Gene (116 / 263)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(reaction)			ABCB1		D004221
CTD	increases(hydrolysis)			ABCB1		D004221
CTD	affects(binding)			ABCB1		D004221
CTD	decreases(reaction)			ABCB1		D004221
CTD	decreases(activity)			ABCB1		D004221
CTD	decreases(activity)			ABCB1		D004221
CTD	decreases(reaction)			ABCB11		D004221
CTD	increases(transport)			ABCB11		D004221
CTD	decreases(activity)			ABCB11		D004221
CTD	affects(reaction)			ABCC1		D004221
CTD	increases(hydrolysis)			ABCC1		D004221
CTD	affects(binding)			ABCC1		D004221
CTD	decreases(reaction)			ABCC1		D004221
CTD	decreases(activity)			ABCC1		D004221
CTD	affects(binding)			ABCC4		D004221
CTD	decreases(reaction)			ABCC4		D004221
CTD	increases(hydrolysis)			ABCC4		D004221
CTD	increases(expression)			AKR1B1		D004221
CTD	increases(expression)			AKR1B10		D004221
CTD	increases(expression)			AKR1C1		D004221
CTD	increases(expression)			AKR1C3		D004221
CTD	decreases(reaction)			ALDH1A1		D004221
CTD	decreases(response to substance)			ALDH1A1		D004221
CTD	decreases(activity)			ALDH1A2		D004221
CTD	decreases(activity)			ALDH2		D004221
CTD	increases(metabolic processing)			ALDH3A1		D004221
CTD	affects(cotreatment)			AR		D004221
CTD	decreases(expression)			AR		D004221
CTD	decreases(activity)			ATF1		D004221
CTD	increases(reaction)			ATF1		D004221
CTD	affects(cotreatment)			ATF1		D004221
CTD	decreases(activity)			ATF2		D004221
CTD	increases(reaction)			ATF2		D004221
CTD	affects(cotreatment)			ATF2		D004221
CTD	increases(expression)			BAX		D004221
CTD	increases(activity)			CASP3		D004221
CTD	increases(activity)			CASP7		D004221
CTD	increases(expression)			CAT		D004221
CTD	affects(cotreatment)			CCNA2		D004221
CTD	decreases(expression)			CCNA2		D004221
CTD	increases(expression)			CDKN1B		D004221
CTD	decreases(activity)			CREB1		D004221
CTD	increases(reaction)			CREB1		D004221
CTD	affects(cotreatment)			CREB1		D004221
CTD	decreases(reaction)			CYP2E1		D004221
CTD	increases(chemical synthesis)			CYP2E1		D004221
CTD	increases(metabolic processing)			CYP2E1		D004221
CTD	decreases(reaction)			CYP2E1		D004221
CTD	increases(oxidation)			CYP2E1		D004221
CTD	decreases(activity)			CYP2E1		D004221
CTD	affects(activity)			CYP2E1		D004221
CTD	decreases(activity)			CYP2E1		D004221
CTD	increases(response to substance)			CYP3A4		D004221
CTD	affects(response to substance)			DBH		D004221
CTD	decreases(activity)			DBH		D004221
CTD	increases(expression)			FECH		D004221
CTD	increases(expression)			FTL		D004221
CTD	increases(expression)			G6PD		D004221
CTD	increases(expression)			GCLC		D004221
CTD	increases(expression)			GCLM		D004221
CTD	increases(expression)			GPX3		D004221
CTD	increases(expression)			GSR		D004221
CTD	increases(expression)			HBG2		D004221
CTD	increases(reaction)			HBG2		D004221
CTD	increases(expression)			HMOX1		D004221
CTD	decreases(activity)			HSD11B2		D004221
CTD	increases(expression)			HSPA1B		D004221
CTD	increases(expression)			MAFF		D004221
CTD	increases(expression)			MAFG		D004221
CTD	increases(expression)			MAFK		D004221
CTD	decreases(expression)			MCM2		D004221
CTD	increases(reaction)			MCM2		D004221
CTD	decreases(expression)			MCM5		D004221
CTD	increases(reaction)			MCM5		D004221
CTD	increases(expression)			ME1		D004221
CTD	increases(expression)			MGST1		D004221
CTD	decreases(expression)			MMP2		D004221
CTD	decreases(expression)			MMP9		D004221
CTD	increases(expression)			MT1B		D004221
CTD	increases(reaction)			MT1B		D004221
CTD	increases(expression)			MT1F		D004221
CTD	increases(reaction)			MT1F		D004221
CTD	increases(expression)			MT1G		D004221
CTD	increases(reaction)			MT1G		D004221
CTD	increases(expression)			MT1X		D004221
CTD	increases(reaction)			MT1X		D004221
CTD	increases(expression)			MT1X		D004221
CTD	increases(expression)			MT2A		D004221
CTD	increases(reaction)			MT2A		D004221
CTD	increases(expression)			NQO1		D004221
CTD	affects(binding)			PARP1		D004221
CTD	increases(cleavage)			PARP1		D004221
CTD	affects(cotreatment)			PARP1		D004221
CTD	increases(cleavage)			PARP1		D004221
CTD	increases(expression)			PGD		D004221
CTD	affects(cotreatment)			PTEN		D004221
CTD	decreases(expression)			PTEN		D004221
CTD	increases(expression)			PTGR1		D004221
CTD	increases(expression)			SOD1		D004221
CTD	increases(expression)			SOD2		D004221
CTD	increases(expression)			SOD3		D004221
CTD	increases(expression)			SPSB1		D004221
CTD	increases(expression)			SRXN1		D004221
CTD	increases(expression)			TXN2		D004221
CTD	increases(expression)			TXNRD1		D004221
CTD	increases(expression)			TXNRD2		D004221
CTD	increases(expression)			UGT1A6		D004221
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	IC50	uM	1.622	ABHD5	-	GI(Protien) :
PubChem	IC50	uM	6.959	ABHD5	-	GI(Protien) :
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	Potency	uM	0.651	ADRB2	-	GI(Protien) :
PubChem	IC50	uM	6.637	AGTR1	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM		AHR	-	GI(Protien) :
PubChem	Potency	uM	0.089	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.100	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.178	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.200	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.282	ALDH1A1	-	GI(Protien) :
PubChem	IC50_Mean	uM	2.630	APLNR	-	GI(Protien) :
PubChem	None	uM		APLNR	-	GI(Protien) :
PubChem	None	uM		APLNR	-	GI(Protien) :
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.099	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.123	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.217	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.266	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	16.031	AR	-	GI(Protien) :
PubChem	Potency	uM	18.349	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.282	CBFB	-	GI(Protien) :
PubChem	Potency	uM	0.794	CBFB	-	GI(Protien) :
PubChem	None	uM		CBR3	-	GI(Protien) :
PubChem	Potency	uM	17.783	CBX1	-	GI(Protien) :
PubChem	Potency	uM	28.184	CBX1	-	GI(Protien) :
PubChem	None	uM		CCR6	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CXCR6	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.035	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.069	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.168	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.794	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	0.398	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	2.512	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	0.891	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	1.259	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	1.337	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	3.548	EHMT2	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	7.943	GLS	-	GI(Protien) :
PubChem	Potency	uM	0.015	GMNN	-	GI(Protien) :
PubChem	Potency	uM	0.030	GMNN	-	GI(Protien) :
PubChem	Potency	uM	0.107	GMNN	-	GI(Protien) :
PubChem	Potency	uM	0.206	GMNN	-	GI(Protien) :
PubChem	Potency	uM	14.581	GMNN	-	GI(Protien) :
PubChem	Potency	uM	21.267	GMNN	-	GI(Protien) :
PubChem	Potency	uM	2.512	HPGD	-	GI(Protien) :
PubChem	Potency	uM	2.818	HPGD	-	GI(Protien) :
PubChem	Potency	uM	3.162	HPGD	-	GI(Protien) :
PubChem	Potency	uM	3.981	HPGD	-	GI(Protien) :
PubChem	AC50_uM	uM	5.178	HSP90AA1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.042	HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.153	HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.750	HSPB1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	10.000	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	1.849	MTOR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.077	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.306	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	7.080	NFKB1	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	70.795	NR1I2	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	IC50	uM		PHOSPHO1	-	GI(Protien) :
PubChem	IC50	uM	6.959	PLIN1	-	GI(Protien) :
PubChem	None	uM		PLIN1	-	GI(Protien) :
PubChem	IC50	uM	1.622	PLIN5	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	Potency	uM	0.844	PLK1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.087	PPARD	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	15.485	PPARG	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	Potency	uM	1.062	RGS4	-	GI(Protien) :
PubChem	Potency	uM	0.282	RUNX1	-	GI(Protien) :
PubChem	Potency	uM	0.794	RUNX1	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	Potency	uM	0.021	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.033	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.045	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.053	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.054	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.054	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.060	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.116	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.141	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.146	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.398	THPO	-	GI(Protien) :
PubChem	Potency	uM	1.259	VDR	-	GI(Protien) :
PubChem	Potency	uM	3.162	VDR	-	GI(Protien) :
PubChem	Potency	uM	5.012	VDR	-	GI(Protien) :
PubChem	Potency	uM	11.220	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	651.300	ADRB2	-	Target : CHEMBL210
ChEMBL	IC50	nM	6637.000	AGTR1	-	Target : CHEMBL227
ChEMBL	Potency	nM	199.500	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	100.000	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	281.800	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	177.800	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	89.100	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	18348.900	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	794.300	CBFB	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	281.800	CBFB	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	28183.800	CBX1	-	Target : CHEMBL1741193
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	6309.570	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1584.890	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	794.330	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	794.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	5011.870	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	5011.900	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	2511.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	2511.890	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	398.100	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	398.110	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	7943.280	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1337.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1258.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3548.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	891.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	21267.100	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	15.100	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	30.000	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	106.600	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	206.000	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	3162.300	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	3981.100	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	2818.400	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	2511.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	158.500	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	79432.800	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	10000.000	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	1849.300	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	7079.500	NFKB1	-	Target : CHEMBL3251
ChEMBL	Potency	nM	794.300	RUNX1	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	281.800	RUNX1	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	398.100	THPO	-	Target : CHEMBL1293256

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