Tan Lab | DSigDB

Gene Set: D4 : CTD - Diethylstilbestrol

Collection

D4 : CTD

Chemical Name

Diethylstilbestrol ( From PubChem : DIETHYLSTILBESTROL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
268.35 g/mol	2	2	4.8286	True

Structure

InChI

InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+

InChIKey

RGLYKWWBQGJZGM-ISLYRVAYSA-N

Links

Gene (233 / 390)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ABCB1		D004054
CTD	decreases(reaction)			ABCB11		D004054
CTD	increases(transport)			ABCB11		D004054
CTD	decreases(activity)			ABCB11		D004054
CTD	decreases(expression)			ABCC3		D004054
CTD	decreases(expression)			ACKR2		D004054
CTD	increases(expression)			ADAMTS9		D004054
CTD	increases(expression)			ADCY1		D004054
CTD	increases(expression)			ADORA1		D004054
CTD	increases(expression)			AFF3		D004054
CTD	affects(binding)			AHR		D004054
CTD	increases(expression)			ALPPL2		D004054
CTD	increases(expression)			ANO1		D004054
CTD	increases(expression)			ANPEP		D004054
CTD	increases(expression)			APOE		D004054
CTD	affects(binding)			AR		D004054
CTD	decreases(activity)			AR		D004054
CTD	affects(binding)			AR		D004054
CTD	decreases(reaction)			AR		D004054
CTD	increases(activity)			AR		D004054
CTD	decreases(activity)			AR		D004054
CTD	decreases(expression)			ARHGDIA		D004054
CTD	increases(expression)			ARHGDIA		D004054
CTD	increases(expression)			ARL4D		D004054
CTD	increases(expression)			ASRGL1		D004054
CTD	increases(expression)			B4GALT1		D004054
CTD	increases(expression)			BFSP2		D004054
CTD	decreases(expression)			C1ORF192		D004054
CTD	decreases(expression)			C20ORF195		D004054
CTD	increases(expression)			CA2		D004054
CTD	increases(expression)			CABLES1		D004054
CTD	decreases(reaction)			CAMK4		D004054
CTD	increases(activity)			CAMK4		D004054
CTD	increases(expression)			CAPN9		D004054
CTD	increases(expression)			CAPNS1		D004054
CTD	decreases(expression)			CASC1		D004054
CTD	increases(activity)			CASP3		D004054
CTD	increases(expression)			CBFA2T3		D004054
CTD	increases(expression)			CCND1		D004054
CTD	increases(expression)			CDC20		D004054
CTD	increases(expression)			CDK10		D004054
CTD	increases(expression)			CDK5		D004054
CTD	increases(expression)			CDKN1C		D004054
CTD	increases(expression)			CEBPB		D004054
CTD	increases(expression)			CEBPD		D004054
CTD	decreases(expression)			CFAP45		D004054
CTD	increases(expression)			CHAC2		D004054
CTD	affects(activity)			CHRNA3		D004054
CTD	affects(binding)			CHRNA3		D004054
CTD	decreases(reaction)			CHRNA3		D004054
CTD	increases(reaction)			CHRNA3		D004054
CTD	affects(activity)			CHRNA4		D004054
CTD	affects(binding)			CHRNA4		D004054
CTD	decreases(reaction)			CHRNA4		D004054
CTD	affects(activity)			CHRNB2		D004054
CTD	affects(binding)			CHRNB2		D004054
CTD	decreases(reaction)			CHRNB2		D004054
CTD	affects(activity)			CHRNB4		D004054
CTD	affects(binding)			CHRNB4		D004054
CTD	decreases(reaction)			CHRNB4		D004054
CTD	increases(reaction)			CHRNB4		D004054
CTD	increases(expression)			CILP		D004054
CTD	increases(expression)			CITED2		D004054
CTD	increases(expression)			CKS1B		D004054
CTD	increases(expression)			CKS2		D004054
CTD	increases(expression)			CLU		D004054
CTD	affects(binding)			CREBBP		D004054
CTD	increases(reaction)			CREBBP		D004054
CTD	increases(activity)			CTSB		D004054
CTD	affects(localization)			CYCS		D004054
CTD	decreases(reaction)			CYCS		D004054
CTD	decreases(expression)			CYP11A1		D004054
CTD	decreases(expression)			CYP1A1		D004054
CTD	affects(response to substance)			CYP1A2		D004054
CTD	increases(expression)			CYP2B6		D004054
CTD	increases(activity)			CYP3A4		D004054
CTD	increases(expression)			CYP3A4		D004054
CTD	increases(expression)			DAD1		D004054
CTD	increases(expression)			DCC		D004054
CTD	increases(expression)			DDIT3		D004054
CTD	increases(expression)			DDR1		D004054
CTD	increases(expression)			DEPTOR		D004054
CTD	increases(expression)			DHRS3		D004054
CTD	decreases(expression)			DLX4		D004054
CTD	increases(expression)			DNPH1		D004054
CTD	increases(expression)			DOK4		D004054
CTD	decreases(expression)			EFEMP2		D004054
CTD	increases(expression)			EGLN3		D004054
CTD	increases(expression)			EGR3		D004054
CTD	increases(expression)			ELF3		D004054
CTD	decreases(expression)			ENO2		D004054
CTD	affects(binding)			EP300		D004054
CTD	increases(reaction)			EP300		D004054
CTD	increases(expression)			EPB41L2		D004054
CTD	decreases(expression)			ERP27		D004054
CTD	increases(expression)			ESPN		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(activity)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(activity)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	affects(cotreatment)			ESR1		D004054
CTD	increases(expression)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	decreases(reaction)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	decreases(reaction)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(reaction)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(reaction)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(reaction)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(reaction)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	increases(reaction)			ESR1		D004054
CTD	affects(localization)			ESR1		D004054
CTD	increases(activity)			ESR1		D004054
CTD	increases(activity)			ESR1		D004054
CTD	affects(response to substance)			ESR1		D004054
CTD	increases(expression)			ESR1		D004054
CTD	affects(binding)			ESR1		D004054
CTD	decreases(reaction)			ESR1		D004054
CTD	increases(activity)			ESR1		D004054
CTD	affects(binding)			ESR2		D004054
CTD	increases(activity)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	affects(cotreatment)			ESR2		D004054
CTD	increases(expression)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	decreases(reaction)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	increases(reaction)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	increases(reaction)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	increases(reaction)			ESR2		D004054
CTD	affects(binding)			ESR2		D004054
CTD	increases(reaction)			ESR2		D004054
CTD	increases(activity)			ESR2		D004054
CTD	increases(expression)			ESR2		D004054
CTD	affects(binding)			ESRRA		D004054
CTD	decreases(activity)			ESRRA		D004054
CTD	decreases(reaction)			ESRRA		D004054
CTD	increases(expression)			ESRRA		D004054
CTD	affects(binding)			ESRRB		D004054
CTD	decreases(activity)			ESRRB		D004054
CTD	decreases(reaction)			ESRRB		D004054
CTD	increases(expression)			ESRRB		D004054
CTD	affects(activity)			ESRRG		D004054
CTD	affects(binding)			ESRRG		D004054
CTD	affects(binding)			ESRRG		D004054
CTD	decreases(activity)			ESRRG		D004054
CTD	affects(binding)			ESRRG		D004054
CTD	increases(activity)			ESRRG		D004054
CTD	affects(binding)			ESRRG		D004054
CTD	decreases(reaction)			ESRRG		D004054
CTD	increases(expression)			ESRRG		D004054
CTD	increases(expression)			EZH2		D004054
CTD	increases(expression)			FAM102A		D004054
CTD	decreases(expression)			FAM107A		D004054
CTD	decreases(expression)			FAM129B		D004054
CTD	increases(expression)			FGR		D004054
CTD	increases(expression)			FHL2		D004054
CTD	increases(expression)			FLT3LG		D004054
CTD	decreases(expression)			FOLR1		D004054
CTD	increases(expression)			FOSL1		D004054
CTD	increases(expression)			FOXD1		D004054
CTD	decreases(expression)			FOXJ1		D004054
CTD	increases(expression)			FUT5		D004054
CTD	increases(expression)			FZD2		D004054
CTD	increases(expression)			FZD5		D004054
CTD	increases(expression)			G0S2		D004054
CTD	increases(expression)			GALNT4		D004054
CTD	decreases(expression)			GALR2		D004054
CTD	increases(expression)			GDPD5		D004054
CTD	increases(expression)			GREB1		D004054
CTD	increases(expression)			GSTM3		D004054
CTD	decreases(reaction)			GSTP1		D004054
CTD	increases(metabolic processing)			GSTP1		D004054
CTD	decreases(expression)			HAPLN3		D004054
CTD	increases(expression)			HES2		D004054
CTD	increases(expression)			HINT1		D004054
CTD	affects(binding)			HOTAIR		D004054
CTD	increases(reaction)			HOTAIR		D004054
CTD	affects(binding)			HOTAIR		D004054
CTD	increases(expression)			HOTAIR		D004054
CTD	increases(reaction)			HOTAIR		D004054
CTD	increases(expression)			HOTAIR		D004054
CTD	affects(binding)			HOXA10		D004054
CTD	increases(reaction)			HOXA10		D004054
CTD	increases(expression)			HOXA10		D004054
CTD	increases(expression)			HOXA9		D004054
CTD	decreases(expression)			HSD17B1		D004054
CTD	decreases(expression)			HSD3B1		D004054
CTD	increases(expression)			IGFBP2		D004054
CTD	increases(expression)			IGFBP6		D004054
CTD	increases(expression)			IL4R		D004054
CTD	increases(expression)			ITGB7		D004054
CTD	increases(expression)			ITPK1		D004054
CTD	increases(expression)			JAG1		D004054
CTD	increases(expression)			JAK3		D004054
CTD	increases(expression)			KCNF1		D004054
CTD	increases(expression)			KCNJ5		D004054
CTD	decreases(expression)			KLK3		D004054
CTD	affects(binding)			KMT2A		D004054
CTD	increases(reaction)			KMT2A		D004054
CTD	increases(expression)			KMT2A		D004054
CTD	affects(binding)			KMT2C		D004054
CTD	increases(reaction)			KMT2C		D004054
CTD	increases(expression)			KMT2C		D004054
CTD	decreases(expression)			KRT17		D004054
CTD	increases(expression)			LAMB3		D004054
CTD	decreases(expression)			LAMP3		D004054
CTD	affects(cotreatment)			LTF		D004054
CTD	increases(expression)			LTF		D004054
CTD	increases(expression)			LYN		D004054
CTD	increases(expression)			MAOA		D004054
CTD	increases(expression)			MAP2K1		D004054
CTD	decreases(expression)			MEOX1		D004054
CTD	increases(expression)			MET		D004054
CTD	decreases(expression)			MFGE8		D004054
CTD	decreases(expression)			MIR34B		D004054
CTD	increases(expression)			MLH1		D004054
CTD	increases(expression)			MLPH		D004054
CTD	increases(expression)			MMP11		D004054
CTD	increases(expression)			MSMB		D004054
CTD	increases(expression)			MYC		D004054
CTD	affects(binding)			MYH10		D004054
CTD	decreases(reaction)			MYH10		D004054
CTD	affects(binding)			NCOA1		D004054
CTD	increases(reaction)			NCOA1		D004054
CTD	affects(binding)			NCOA1		D004054
CTD	increases(reaction)			NCOA1		D004054
CTD	affects(binding)			NCOA1		D004054
CTD	increases(reaction)			NCOA1		D004054
CTD	affects(binding)			NCOA1		D004054
CTD	increases(reaction)			NCOA1		D004054
CTD	affects(binding)			NCOA2		D004054
CTD	affects(binding)			NCOA2		D004054
CTD	increases(reaction)			NCOA2		D004054
CTD	affects(binding)			NCOA2		D004054
CTD	increases(reaction)			NCOA2		D004054
CTD	decreases(expression)			NGEF		D004054
CTD	increases(expression)			NME1		D004054
CTD	increases(expression)			NME2		D004054
CTD	increases(expression)			NOP2		D004054
CTD	affects(binding)			NR1I2		D004054
CTD	increases(activity)			NR1I2		D004054
CTD	affects(binding)			NR1I3		D004054
CTD	increases(reaction)			NR1I3		D004054
CTD	increases(expression)			NRIP1		D004054
CTD	increases(expression)			NRTN		D004054
CTD	increases(expression)			OLFM1		D004054
CTD	increases(expression)			OLFML3		D004054
CTD	increases(expression)			PDCD6		D004054
CTD	increases(expression)			PDZK1		D004054
CTD	increases(expression)			PGR		D004054
CTD	increases(expression)			PGR		D004054
CTD	decreases(reaction)			PGR		D004054
CTD	increases(expression)			PGR		D004054
CTD	decreases(expression)			PIK3IP1		D004054
CTD	increases(expression)			PIM1		D004054
CTD	increases(expression)			PKDCC		D004054
CTD	increases(expression)			PLCB1		D004054
CTD	increases(expression)			PLXDC2		D004054
CTD	increases(expression)			POLA1		D004054
CTD	increases(expression)			PRKCSH		D004054
CTD	decreases(reaction)			PRL		D004054
CTD	increases(secretion)			PRL		D004054
CTD	decreases(expression)			PRODH		D004054
CTD	increases(expression)			PRR5L		D004054
CTD	increases(expression)			PTMA		D004054
CTD	decreases(expression)			RAB20		D004054
CTD	increases(expression)			RAP1GAP		D004054
CTD	decreases(expression)			RASAL1		D004054
CTD	increases(expression)			RBM24		D004054
CTD	decreases(expression)			RBP1		D004054
CTD	increases(activity)			RELA		D004054
CTD	increases(expression)			RELN		D004054
CTD	increases(activity)			REN		D004054
CTD	increases(expression)			RFC5		D004054
CTD	increases(expression)			RGS10		D004054
CTD	increases(expression)			RPA3		D004054
CTD	increases(expression)			RPS19		D004054
CTD	increases(expression)			RPS3A		D004054
CTD	increases(expression)			S1PR3		D004054
CTD	decreases(expression)			SAT1		D004054
CTD	decreases(expression)			SELENBP1		D004054
CTD	increases(expression)			SERPINA3		D004054
CTD	increases(expression)			SIAH2		D004054
CTD	increases(expression)			SKI		D004054
CTD	decreases(expression)			SLC12A2		D004054
CTD	affects(transport)			SLC2A1		D004054
CTD	decreases(reaction)			SLC2A1		D004054
CTD	decreases(activity)			SLC2A1		D004054
CTD	increases(expression)			SLC3A2		D004054
CTD	increases(expression)			SLC6A14		D004054
CTD	increases(expression)			SLC6A6		D004054
CTD	increases(expression)			SLC7A11		D004054
CTD	increases(expression)			SLC7A5		D004054
CTD	decreases(localization)			SOX17		D004054
CTD	increases(expression)			SOX17		D004054
CTD	increases(expression)			STAT1		D004054
CTD	decreases(activity)			STS		D004054
CTD	decreases(activity)			SULT1E1		D004054
CTD	decreases(reaction)			TFF1		D004054
CTD	increases(expression)			TFF1		D004054
CTD	increases(expression)			TFF1		D004054
CTD	increases(expression)			TGFA		D004054
CTD	increases(expression)			TGFB3		D004054
CTD	increases(expression)			THBS1		D004054
CTD	decreases(expression)			TNFRSF25		D004054
CTD	increases(expression)			TNK2		D004054
CTD	increases(expression)			TOB1		D004054
CTD	increases(expression)			TRAF3		D004054
CTD	decreases(reaction)			TRPC5		D004054
CTD	increases(transport)			TRPC5		D004054
CTD	decreases(reaction)			TSHB		D004054
CTD	increases(abundance)			TSHB		D004054
CTD	increases(activity)			TSHB		D004054
CTD	decreases(reaction)			TSHR		D004054
CTD	increases(abundance)			TSHR		D004054
CTD	increases(activity)			TSHR		D004054
CTD	decreases(expression)			TUBB4A		D004054
CTD	decreases(reaction)			UGT1A1		D004054
CTD	increases(glucuronidation)			UGT1A1		D004054
CTD	decreases(reaction)			UGT1A3		D004054
CTD	increases(glucuronidation)			UGT1A3		D004054
CTD	decreases(reaction)			UGT1A8		D004054
CTD	increases(glucuronidation)			UGT1A8		D004054
CTD	decreases(reaction)			UGT2B7		D004054
CTD	increases(glucuronidation)			UGT2B7		D004054
CTD	increases(expression)			WARS		D004054
CTD	increases(expression)			WNT2B		D004054
CTD	decreases(expression)			WNT7A		D004054
CTD	increases(expression)			YWHAB		D004054
CTD	decreases(expression)			ZMYND10		D004054
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.238	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	27.715	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	33.360	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.641	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.558	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	50.457	AR	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	60.634	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.000	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.001	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.002	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.004	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	30.654	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	48.966	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.966	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	54.040	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.040	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	54.483	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.511	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	23.715	GMNN	-	GI(Protien) :
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	54.941	HSPB1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.782	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	29.849	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	39.811	NR1H4	-	GI(Protien) :
PubChem	Potency	uM	44.668	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	IC50	uM	12.589	SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TNNC1	-	GI(Protien) :
PubChem	None	uM		TNNI3	-	GI(Protien) :
PubChem	None	uM		TNNT2	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	CYP3A4	-	Target : CHEMBL340

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