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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - Dichlororibofuranosylbenzimidazole

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Collection	D4 : CTD
Chemical Name	Dichlororibofuranosylbenzimidazole ( From PubChem : MLS003171503 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 319.141 g/mol 3 6 0.9546 True
Structure
InChI	InChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10+,11-,12-/m0/s1
InChIKey	XHSQDZXAVJRBMX-USZNOCQGSA-N
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Gene (17 / 33) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ABCB1 D004004 CTD increases(expression) ABCB1 D004004 CTD decreases(reaction) ABCB1 D004004 CTD increases(expression) ABCB1 D004004 CTD decreases(expression) ABL1 D004004 CTD increases(reaction) ABL1 D004004 CTD decreases(reaction) BCL2L1 D004004 CTD increases(expression) BCL2L1 D004004 CTD decreases(reaction) CDKN1A D004004 CTD increases(expression) CDKN1A D004004 CTD decreases(reaction) CES2 D004004 CTD increases(expression) CES2 D004004 CTD decreases(expression) CFTR D004004 CTD decreases(reaction) CFTR D004004 CTD decreases(reaction) CYP3A4 D004004 CTD increases(expression) CYP3A4 D004004 CTD affects(localization) FBL D004004 CTD decreases(reaction) HIF1A D004004 CTD increases(expression) HIF1A D004004 CTD affects(cotreatment) PARP1 D004004 CTD increases(cleavage) PARP1 D004004 CTD decreases(phosphorylation) POLR2A D004004 CTD increases(reaction) POLR2A D004004 CTD affects(expression) SLC38A2 D004004 CTD decreases(reaction) TNF D004004 CTD increases(expression) TNF D004004 CTD decreases(reaction) TYMS D004004 CTD increases(expression) TYMS D004004 PubChem Potency uM 14.581 TDP1 - GI(Protien) : PubChem Potency uM 8.912 ATAD5 - GI(Protien) : PubChem None uM IL1B - GI(Protien) : PubChem Potency uM 14.581 TDP1 - GI(Protien) : ChEMBL Potency nM 8912.500 ATAD5 - Target : CHEMBL1741209
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