Tan Lab | DSigDB

Gene Set: D4 : CTD - DDT

Collection

D4 : CTD

Chemical Name

DDT ( From PubChem : CHLOROPHENOTHANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
354.486 g/mol	0	0	6.4955	False(3/4)

Structure

InChI

InChI=1S/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H

InChIKey

YVGGHNCTFXOJCH-UHFFFAOYSA-N

Links

Gene (90 / 191)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB1		D003634
CTD	increases(expression)			ABCB1		D003634
CTD	increases(expression)			ABCC2		D003634
CTD	decreases(activity)			ABCG2		D003634
CTD	affects(binding)			AHR		D003634
CTD	affects(cotreatment)			AHR		D003634
CTD	increases(expression)			AHR		D003634
CTD	decreases(expression)			ALB		D003634
CTD	affects(cotreatment)			AR		D003634
CTD	decreases(reaction)			AR		D003634
CTD	increases(expression)			AR		D003634
CTD	affects(binding)			AR		D003634
CTD	decreases(activity)			AR		D003634
CTD	affects(binding)			AR		D003634
CTD	affects(binding)			AR		D003634
CTD	decreases(reaction)			AR		D003634
CTD	increases(activity)			AR		D003634
CTD	decreases(reaction)			AR		D003634
CTD	decreases(reaction)			AR		D003634
CTD	increases(activity)			AR		D003634
CTD	increases(activity)			BCL2		D003634
CTD	increases(expression)			BCL2		D003634
CTD	increases(activity)			CASP3		D003634
CTD	decreases(reaction)			CASP3		D003634
CTD	increases(activity)			CASP7		D003634
CTD	decreases(reaction)			CASP7		D003634
CTD	increases(expression)			CCND1		D003634
CTD	decreases(expression)			CDH1		D003634
CTD	decreases(reaction)			CDH1		D003634
CTD	affects(binding)			CDH1		D003634
CTD	decreases(reaction)			CDH1		D003634
CTD	decreases(expression)			CDH1		D003634
CTD	decreases(expression)			CDH1		D003634
CTD	decreases(reaction)			CDH2		D003634
CTD	increases(expression)			CDH2		D003634
CTD	increases(activity)			CDK2		D003634
CTD	increases(activity)			CDK2		D003634
CTD	increases(phosphorylation)			CDK2		D003634
CTD	decreases(reaction)			CDK2		D003634
CTD	decreases(reaction)			CFTR		D003634
CTD	increases(expression)			CFTR		D003634
CTD	increases(stability)			CFTR		D003634
CTD	increases(expression)			COL1A1		D003634
CTD	increases(activity)			CREB1		D003634
CTD	increases(activity)			CREBBP		D003634
CTD	affects(binding)			CTNNB1		D003634
CTD	decreases(reaction)			CTNNB1		D003634
CTD	increases(expression)			CTNNB1		D003634
CTD	increases(activity)			CTSD		D003634
CTD	increases(expression)			CTSD		D003634
CTD	increases(expression)			CYP11A1		D003634
CTD	decreases(reaction)			CYP1A1		D003634
CTD	increases(expression)			CYP1A1		D003634
CTD	affects(cotreatment)			CYP1A1		D003634
CTD	increases(expression)			CYP1A1		D003634
CTD	affects(cotreatment)			CYP1B1		D003634
CTD	increases(expression)			CYP1B1		D003634
CTD	increases(expression)			CYP2B6		D003634
CTD	increases(expression)			CYP2B6		D003634
CTD	increases(expression)			CYP3A4		D003634
CTD	increases(expression)			CYP3A4		D003634
CTD	increases(activity)			ELK1		D003634
CTD	increases(phosphorylation)			ERBB2		D003634
CTD	affects(cotreatment)			ESR1		D003634
CTD	increases(expression)			ESR1		D003634
CTD	affects(binding)			ESR1		D003634
CTD	increases(activity)			ESR1		D003634
CTD	affects(binding)			ESR1		D003634
CTD	increases(activity)			ESR1		D003634
CTD	decreases(expression)			ESR1		D003634
CTD	increases(activity)			ESR1		D003634
CTD	increases(expression)			ESR1		D003634
CTD	affects(cotreatment)			ESR1		D003634
CTD	increases(expression)			ESR1		D003634
CTD	affects(binding)			ESR2		D003634
CTD	increases(activity)			ESR2		D003634
CTD	increases(activity)			ESR2		D003634
CTD	increases(expression)			FAM102A		D003634
CTD	increases(expression)			FN1		D003634
CTD	increases(activity)			FOS		D003634
CTD	increases(expression)			FOSL1		D003634
CTD	decreases(expression)			GABRP		D003634
CTD	increases(activity)			GABRP		D003634
CTD	affects(cotreatment)			GJA1		D003634
CTD	decreases(expression)			GJA1		D003634
CTD	affects(cotreatment)			GNRH1		D003634
CTD	increases(expression)			GNRH1		D003634
CTD	affects(binding)			GPER1		D003634
CTD	affects(binding)			GRB2		D003634
CTD	increases(reaction)			GRB2		D003634
CTD	decreases(expression)			GSN		D003634
CTD	increases(activity)			GSN		D003634
CTD	decreases(expression)			HSD17B1		D003634
CTD	decreases(reaction)			HSD17B1		D003634
CTD	increases(expression)			HSD3B1		D003634
CTD	increases(expression)			HSPA5		D003634
CTD	decreases(expression)			IL2		D003634
CTD	affects(cotreatment)			IL4		D003634
CTD	increases(expression)			IL4		D003634
CTD	increases(expression)			ITGA5		D003634
CTD	decreases(reaction)			ITGB1		D003634
CTD	increases(expression)			ITGB1		D003634
CTD	decreases(reaction)			JAK1		D003634
CTD	increases(phosphorylation)			JAK1		D003634
CTD	increases(activity)			JUN		D003634
CTD	increases(expression)			JUN		D003634
CTD	increases(activity)			MAP2K6		D003634
CTD	increases(reaction)			MAP2K6		D003634
CTD	increases(activity)			MAPK1		D003634
CTD	increases(phosphorylation)			MAPK1		D003634
CTD	increases(phosphorylation)			MAPK1		D003634
CTD	increases(phosphorylation)			MAPK14		D003634
CTD	increases(activity)			MAPK3		D003634
CTD	increases(phosphorylation)			MAPK3		D003634
CTD	increases(phosphorylation)			MAPK3		D003634
CTD	decreases(phosphorylation)			MAPK8		D003634
CTD	decreases(phosphorylation)			MAPK9		D003634
CTD	increases(phosphorylation)			MET		D003634
CTD	increases(expression)			MIR149		D003634
CTD	decreases(expression)			MIR15B		D003634
CTD	decreases(expression)			MIR16-1		D003634
CTD	increases(expression)			MIR1915		D003634
CTD	increases(expression)			MIR193A		D003634
CTD	decreases(expression)			MIR21		D003634
CTD	decreases(expression)			MIR27B		D003634
CTD	decreases(expression)			MIR342		D003634
CTD	increases(expression)			MIR638		D003634
CTD	increases(expression)			MIR663A		D003634
CTD	decreases(expression)			MIR92B		D003634
CTD	decreases(expression)			MIR99B		D003634
CTD	decreases(reaction)			MMP3		D003634
CTD	increases(expression)			MMP3		D003634
CTD	decreases(expression)			MT2A		D003634
CTD	decreases(reaction)			MT2A		D003634
CTD	decreases(expression)			NFKB1		D003634
CTD	increases(activity)			NOTCH1		D003634
CTD	increases(reaction)			NOTCH1		D003634
CTD	affects(binding)			NR1I2		D003634
CTD	increases(activity)			NR1I2		D003634
CTD	increases(activity)			NR1I2		D003634
CTD	affects(binding)			NR1I3		D003634
CTD	increases(activity)			NR1I3		D003634
CTD	increases(localization)			NR1I3		D003634
CTD	increases(expression)			PDCD4		D003634
CTD	affects(binding)			PGR		D003634
CTD	decreases(reaction)			PGR		D003634
CTD	decreases(reaction)			PGR		D003634
CTD	increases(expression)			PGR		D003634
CTD	increases(activity)			PGR		D003634
CTD	increases(expression)			PGR		D003634
CTD	affects(cotreatment)			POMC		D003634
CTD	increases(expression)			POMC		D003634
CTD	decreases(reaction)			PTGS2		D003634
CTD	increases(expression)			PTGS2		D003634
CTD	increases(phosphorylation)			RB1		D003634
CTD	increases(activity)			RXRB		D003634
CTD	increases(activity)			SERPINB5		D003634
CTD	increases(expression)			SERPINB5		D003634
CTD	decreases(expression)			SLC10A1		D003634
CTD	affects(binding)			SOS1		D003634
CTD	increases(reaction)			SOS1		D003634
CTD	increases(phosphorylation)			STAT1		D003634
CTD	decreases(reaction)			STAT3		D003634
CTD	increases(expression)			STAT3		D003634
CTD	increases(phosphorylation)			STAT3		D003634
CTD	affects(localization)			STAT3		D003634
CTD	increases(activity)			TFF1		D003634
CTD	increases(expression)			TFF1		D003634
CTD	decreases(reaction)			TNF		D003634
CTD	increases(expression)			TNF		D003634
CTD	increases(expression)			TNF		D003634
CTD	decreases(reaction)			TNF		D003634
CTD	increases(expression)			TNF		D003634
CTD	affects(binding)			TSHR		D003634
CTD	decreases(activity)			TSHR		D003634
CTD	decreases(activity)			TSHR		D003634
CTD	decreases(localization)			TSHR		D003634
CTD	decreases(reaction)			VEGFA		D003634
CTD	increases(expression)			VEGFA		D003634
CTD	increases(expression)			VIM		D003634
PubChem	Ratio Potency (uM)	uM	28.613	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.364	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.157	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.555	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.591	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	30.903	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	62.090	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		ESR1	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	39.811	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.641	NR3C1	-	GI(Protien) :

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