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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - Dichlorodiphenyl Dichloroethylene

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Collection	D4 : CTD
Chemical Name	Dichlorodiphenyl Dichloroethylene ( From PubChem : P,P'-DDE )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 318.025 g/mol 0 0 6.1879 False(3/4)
Structure
InChI	InChI=1S/C14H8Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8H
InChIKey	UCNVFOCBFJOQAL-UHFFFAOYSA-N
Links
Gene (45 / 129) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) ABCB1 D003633 CTD increases(expression) ABCB1 D003633 CTD decreases(activity) ABCG2 D003633 CTD affects(cotreatment) ACVR1C D003633 CTD increases(expression) ACVR1C D003633 CTD affects(cotreatment) ACVRL1 D003633 CTD increases(expression) ACVRL1 D003633 CTD affects(cotreatment) ALK D003633 CTD increases(expression) ALK D003633 CTD affects(cotreatment) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD affects(reaction) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD affects(binding) AR D003633 CTD decreases(activity) AR D003633 CTD affects(binding) AR D003633 CTD increases(activity) AR D003633 CTD affects(binding) AR D003633 CTD affects(binding) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD affects(binding) AR D003633 CTD decreases(reaction) AR D003633 CTD affects(cotreatment) AR D003633 CTD decreases(expression) AR D003633 CTD decreases(reaction) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(expression) AR D003633 CTD affects(binding) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD increases(activity) AR D003633 CTD increases(activity) AR D003633 CTD affects(binding) AR D003633 CTD increases(reaction) AR D003633 CTD increases(expression) AR D003633 CTD increases(phosphorylation) AR D003633 CTD increases(expression) AR D003633 CTD decreases(reaction) AR D003633 CTD increases(activity) AR D003633 CTD increases(expression) BAX D003633 CTD increases(expression) BCL2 D003633 CTD increases(cleavage) BID D003633 CTD increases(expression) BRCA1 D003633 CTD decreases(reaction) BRCA1 D003633 CTD increases(activity) CASP3 D003633 CTD increases(activity) CASP8 D003633 CTD increases(activity) CASP9 D003633 CTD increases(expression) CCND1 D003633 CTD decreases(reaction) CCND1 D003633 CTD decreases(expression) CLU D003633 CTD decreases(reaction) CLU D003633 CTD increases(activity) CREBBP D003633 CTD affects(cotreatment) CYP19A1 D003633 CTD increases(activity) CYP19A1 D003633 CTD increases(activity) CYP19A1 D003633 CTD increases(expression) CYP19A1 D003633 CTD increases(expression) CYP19A1 D003633 CTD increases(expression) CYP1B1 D003633 CTD increases(expression) CYP2B6 D003633 CTD increases(expression) CYP3A4 D003633 CTD affects(cotreatment) ERBB3 D003633 CTD increases(expression) ERBB3 D003633 CTD increases(activity) ESR1 D003633 CTD affects(binding) ESR1 D003633 CTD affects(cotreatment) ESR1 D003633 CTD decreases(expression) ESR1 D003633 CTD decreases(reaction) ESR1 D003633 CTD affects(binding) ESR1 D003633 CTD decreases(reaction) ESR1 D003633 CTD affects(binding) ESR1 D003633 CTD decreases(expression) ESR1 D003633 CTD increases(activity) ESR1 D003633 CTD increases(expression) ESR1 D003633 CTD decreases(reaction) ESR1 D003633 CTD increases(activity) ESR2 D003633 CTD affects(binding) ESR2 D003633 CTD affects(cotreatment) FSHB D003633 CTD increases(activity) FSHB D003633 CTD affects(cotreatment) IL4 D003633 CTD increases(expression) IL4 D003633 CTD affects(cotreatment) KIT D003633 CTD increases(expression) KIT D003633 CTD affects(binding) KLK3 D003633 CTD increases(activity) KLK3 D003633 CTD increases(reaction) KLK3 D003633 CTD increases(expression) KLK3 D003633 CTD increases(activity) MAPK1 D003633 CTD increases(phosphorylation) MAPK1 D003633 CTD increases(activity) MAPK3 D003633 CTD increases(phosphorylation) MAPK3 D003633 CTD increases(expression) NFKB1 D003633 CTD increases(phosphorylation) NFKBIA D003633 CTD affects(binding) NR1I2 D003633 CTD increases(activity) NR1I2 D003633 CTD increases(activity) PARP1 D003633 CTD affects(cotreatment) PDGFRA D003633 CTD increases(expression) PDGFRA D003633 CTD affects(cotreatment) PDGFRB D003633 CTD increases(expression) PDGFRB D003633 CTD affects(binding) PGR D003633 CTD decreases(reaction) PGR D003633 CTD decreases(reaction) PGR D003633 CTD increases(expression) PGR D003633 CTD increases(expression) PGR D003633 CTD increases(expression) PGR D003633 CTD decreases(reaction) PGR D003633 CTD increases(expression) PTGS2 D003633 CTD increases(expression) SOD1 D003633 CTD decreases(activity) SRD5A2 D003633 CTD affects(cotreatment) TFF1 D003633 CTD increases(expression) TFF1 D003633 CTD increases(expression) TFF1 D003633 CTD decreases(reaction) TFF1 D003633 CTD increases(expression) TNF D003633 CTD increases(expression) TP53 D003633 CTD increases(activity) VASP D003633 CTD increases(phosphorylation) VASP D003633 PubChem Potency uM 7.943 CYP3A4 - GI(Protien) : PubChem Potency uM 66.824 NFE2L2 - GI(Protien) : PubChem Ratio Potency (uM) uM 75.873 NFE2L2 - GI(Protien) : PubChem None uM PAFAH1B2 - GI(Protien) : ChEMBL Potency nM 7943.300 CYP3A4 - Target : CHEMBL340
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