Tan Lab | DSigDB

Gene Set: D4 : CTD - Daunorubicin

Collection

D4 : CTD

Chemical Name

Daunorubicin ( From PubChem : DAUNORUBICIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
527.52 g/mol	5	11	1.7292	False(2/4)

Structure

InChI

InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1

InChIKey

STQGQHZAVUOBTE-VGBVRHCVSA-N

Links

Gene (146 / 295)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(response to substance)			ABCB1		D003630
CTD	decreases(expression)			ABCB1		D003630
CTD	increases(reaction)			ABCB1		D003630
CTD	increases(reaction)			ABCB1		D003630
CTD	increases(response to substance)			ABCB1		D003630
CTD	decreases(uptake)			ABCB1		D003630
CTD	increases(export)			ABCB1		D003630
CTD	increases(transport)			ABCB1		D003630
CTD	decreases(reaction)			ABCB1		D003630
CTD	increases(transport)			ABCB1		D003630
CTD	decreases(reaction)			ABCB1		D003630
CTD	increases(transport)			ABCB1		D003630
CTD	decreases(response to substance)			ABCB1		D003630
CTD	decreases(reaction)			ABCB1		D003630
CTD	increases(export)			ABCB1		D003630
CTD	affects(cotreatment)			ABCB1		D003630
CTD	decreases(expression)			ABCB1		D003630
CTD	decreases(expression)			ABCB1		D003630
CTD	decreases(reaction)			ABCB1		D003630
CTD	increases(export)			ABCB1		D003630
CTD	decreases(reaction)			ABCB1		D003630
CTD	decreases(response to substance)			ABCB1		D003630
CTD	affects(cotreatment)			ABCB1		D003630
CTD	affects(response to substance)			ABCC1		D003630
CTD	affects(export)			ABCC1		D003630
CTD	affects(response to substance)			ABCC1		D003630
CTD	decreases(response to substance)			ABCC1		D003630
CTD	increases(secretion)			ABCC1		D003630
CTD	decreases(response to substance)			ABCC1		D003630
CTD	decreases(reaction)			ABCC1		D003630
CTD	increases(secretion)			ABCC1		D003630
CTD	decreases(reaction)			ABCC1		D003630
CTD	decreases(reaction)			ABCC1		D003630
CTD	increases(secretion)			ABCC1		D003630
CTD	decreases(reaction)			ABCC1		D003630
CTD	affects(response to substance)			ABCC2		D003630
CTD	decreases(reaction)			ABCG2		D003630
CTD	increases(expression)			ABCG2		D003630
CTD	decreases(response to substance)			ABL1		D003630
CTD	increases(expression)			AGRN		D003630
CTD	increases(reduction)			AKR1A1		D003630
CTD	increases(metabolic processing)			AKR1A1		D003630
CTD	increases(chemical synthesis)			AKR1A1		D003630
CTD	affects(metabolic processing)			AKR1A1		D003630
CTD	increases(reduction)			AKR1B1		D003630
CTD	decreases(response to substance)			AKR1B10		D003630
CTD	increases(reduction)			AKR1B10		D003630
CTD	increases(chemical synthesis)			AKR1B10		D003630
CTD	decreases(reaction)			AKR1B10		D003630
CTD	increases(metabolic processing)			AKR1C3		D003630
CTD	decreases(response to substance)			AKT1		D003630
CTD	affects(response to substance)			ANO3		D003630
CTD	decreases(expression)			ANXA2		D003630
CTD	increases(expression)			ANXA4		D003630
CTD	increases(reduction)			APEX1		D003630
CTD	increases(response to substance)			APEX1		D003630
CTD	increases(expression)			ATM		D003630
CTD	affects(expression)			BARD1		D003630
CTD	affects(cotreatment)			BAX		D003630
CTD	increases(expression)			BAX		D003630
CTD	increases(reaction)			BAX		D003630
CTD	affects(cotreatment)			BAX		D003630
CTD	increases(expression)			BAX		D003630
CTD	affects(cotreatment)			BAX		D003630
CTD	increases(expression)			BAX		D003630
CTD	decreases(response to substance)			BCL2		D003630
CTD	affects(cotreatment)			BCL2		D003630
CTD	decreases(expression)			BCL2		D003630
CTD	affects(cotreatment)			BCL2		D003630
CTD	decreases(expression)			BCL2		D003630
CTD	increases(reaction)			BCL2		D003630
CTD	affects(cotreatment)			BCL2		D003630
CTD	decreases(expression)			BCL2		D003630
CTD	affects(cotreatment)			BCL2		D003630
CTD	decreases(expression)			BCL2		D003630
CTD	affects(cotreatment)			BID		D003630
CTD	increases(expression)			BID		D003630
CTD	affects(cotreatment)			BIRC5		D003630
CTD	decreases(expression)			BIRC5		D003630
CTD	affects(expression)			BIRC5		D003630
CTD	affects(cotreatment)			BIRC5		D003630
CTD	decreases(expression)			BIRC5		D003630
CTD	increases(expression)			BIRC5		D003630
CTD	affects(response to substance)			C4ORF45		D003630
CTD	decreases(expression)			CAB39		D003630
CTD	affects(response to substance)			CACNA1S		D003630
CTD	affects(cotreatment)			CASP3		D003630
CTD	increases(expression)			CASP3		D003630
CTD	increases(reaction)			CASP3		D003630
CTD	affects(cotreatment)			CASP3		D003630
CTD	increases(expression)			CASP3		D003630
CTD	affects(cotreatment)			CASP3		D003630
CTD	increases(expression)			CASP3		D003630
CTD	affects(cotreatment)			CASP3		D003630
CTD	increases(activity)			CASP3		D003630
CTD	increases(activity)			CASP3		D003630
CTD	affects(cotreatment)			CASP8		D003630
CTD	increases(activity)			CASP8		D003630
CTD	affects(response to substance)			CAT		D003630
CTD	decreases(metabolic processing)			CBR1		D003630
CTD	increases(reduction)			CBR1		D003630
CTD	increases(metabolic processing)			CBR1		D003630
CTD	increases(chemical synthesis)			CBR1		D003630
CTD	affects(binding)			CBR1		D003630
CTD	decreases(reaction)			CBR1		D003630
CTD	increases(metabolic processing)			CBR1		D003630
CTD	affects(response to substance)			CBR3		D003630
CTD	affects(metabolic processing)			CBR3		D003630
CTD	decreases(expression)			CCL2		D003630
CTD	decreases(expression)			CCL4		D003630
CTD	increases(expression)			CCND3		D003630
CTD	affects(expression)			CCNE1		D003630
CTD	increases(expression)			CCNG2		D003630
CTD	increases(expression)			CDC25A		D003630
CTD	affects(response to substance)			CDH13		D003630
CTD	increases(expression)			CDKN1A		D003630
CTD	increases(expression)			CDKN1A		D003630
CTD	affects(expression)			CDKN2A		D003630
CTD	increases(expression)			CDKN2B		D003630
CTD	increases(expression)			CEACAM1		D003630
CTD	decreases(expression)			CEBPZ		D003630
CTD	increases(expression)			CLK2		D003630
CTD	affects(response to substance)			CLYBL		D003630
CTD	affects(response to substance)			CMC2		D003630
CTD	affects(response to substance)			CMIP		D003630
CTD	affects(response to substance)			CWC27		D003630
CTD	decreases(expression)			CXCL8		D003630
CTD	affects(response to substance)			CYP1B1		D003630
CTD	increases(degradation)			DFFA		D003630
CTD	increases(expression)			E2F5		D003630
CTD	decreases(reaction)			EGF		D003630
CTD	increases(abundance)			EGF		D003630
CTD	increases(expression)			EI24		D003630
CTD	increases(phosphorylation)			EIF4EBP1		D003630
CTD	decreases(reaction)			EIF4EBP1		D003630
CTD	increases(expression)			EPM2AIP1		D003630
CTD	increases(expression)			F3		D003630
CTD	increases(expression)			FDXR		D003630
CTD	affects(response to substance)			GAPT		D003630
CTD	affects(response to substance)			GPC5		D003630
CTD	affects(response to substance)			GSTM1		D003630
CTD	affects(response to substance)			HNRNPD		D003630
CTD	affects(response to substance)			IKBKE		D003630
CTD	decreases(expression)			IL6R		D003630
CTD	affects(response to substance)			ILKAP		D003630
CTD	affects(response to substance)			INPP4B		D003630
CTD	affects(response to substance)			KIF1A		D003630
CTD	affects(response to substance)			LSAMP		D003630
CTD	affects(response to substance)			LUZP2		D003630
CTD	affects(response to substance)			MAP1B		D003630
CTD	increases(expression)			MAP2K3		D003630
CTD	decreases(expression)			MAP3K5		D003630
CTD	decreases(expression)			MAPT		D003630
CTD	decreases(expression)			MDM4		D003630
CTD	decreases(response to substance)			MIR21		D003630
CTD	increases(phosphorylation)			MTOR		D003630
CTD	decreases(reaction)			MTOR		D003630
CTD	decreases(expression)			NCK2		D003630
CTD	affects(response to substance)			NGEF		D003630
CTD	decreases(reaction)			NPC1		D003630
CTD	increases(secretion)			NPC1		D003630
CTD	affects(response to substance)			NPC1		D003630
CTD	increases(expression)			NPPB		D003630
CTD	decreases(expression)			NQO1		D003630
CTD	decreases(activity)			NR3C1		D003630
CTD	increases(expression)			NRAS		D003630
CTD	affects(cotreatment)			PARP1		D003630
CTD	increases(cleavage)			PARP1		D003630
CTD	increases(cleavage)			PARP1		D003630
CTD	affects(response to substance)			PIK3R1		D003630
CTD	increases(abundance)			PLAT		D003630
CTD	increases(secretion)			PLAT		D003630
CTD	increases(expression)			PLK3		D003630
CTD	decreases(response to substance)			PPP1R13L		D003630
CTD	decreases(expression)			PRC1		D003630
CTD	increases(cleavage)			PRKCD		D003630
CTD	decreases(response to substance)			PRKCZ		D003630
CTD	affects(response to substance)			PSME2P3		D003630
CTD	increases(response to substance)			PTEN		D003630
CTD	affects(response to substance)			RANBP17		D003630
CTD	increases(expression)			RB1		D003630
CTD	affects(expression)			RBBP5		D003630
CTD	increases(expression)			RBBP6		D003630
CTD	affects(cotreatment)			RELA		D003630
CTD	decreases(expression)			RELA		D003630
CTD	increases(phosphorylation)			RPS6KB1		D003630
CTD	decreases(reaction)			RPS6KB1		D003630
CTD	increases(expression)			SDC1		D003630
CTD	decreases(expression)			SERPINE1		D003630
CTD	decreases(secretion)			SERPINE1		D003630
CTD	increases(abundance)			SERPINE1		D003630
CTD	decreases(reaction)			SERPINE1		D003630
CTD	decreases(reaction)			SLC22A16		D003630
CTD	increases(uptake)			SLC22A16		D003630
CTD	affects(response to substance)			SLIT3		D003630
CTD	increases(activity)			SMPD1		D003630
CTD	increases(expression)			SMPD1		D003630
CTD	increases(expression)			SMPD3		D003630
CTD	increases(response to substance)			SMPD3		D003630
CTD	affects(response to substance)			SNW1		D003630
CTD	affects(response to substance)			SP110		D003630
CTD	increases(expression)			SP3		D003630
CTD	affects(response to substance)			TAGLN3		D003630
CTD	increases(expression)			TAP1		D003630
CTD	affects(response to substance)			TAP2		D003630
CTD	increases(expression)			TAX1BP3		D003630
CTD	affects(response to substance)			TM4SF20		D003630
CTD	increases(expression)			TNFRSF10A		D003630
CTD	increases(reaction)			TNFRSF10A		D003630
CTD	increases(expression)			TNFRSF10B		D003630
CTD	increases(reaction)			TNFRSF10B		D003630
CTD	affects(cotreatment)			TNFSF10		D003630
CTD	increases(activity)			TNFSF10		D003630
CTD	increases(cleavage)			TNFSF10		D003630
CTD	increases(expression)			TNFSF10		D003630
CTD	increases(expression)			TNFSF10		D003630
CTD	increases(reaction)			TNFSF10		D003630
CTD	increases(expression)			TNFSF9		D003630
CTD	affects(cotreatment)			TP53		D003630
CTD	increases(activity)			TP53		D003630
CTD	increases(activity)			TP53		D003630
CTD	increases(expression)			TP53		D003630
CTD	increases(expression)			TP53I3		D003630
CTD	increases(expression)			TP53TG1		D003630
CTD	affects(response to substance)			TYMS		D003630
CTD	affects(response to substance)			VDR		D003630
CTD	decreases(expression)			VEGFA		D003630
CTD	affects(response to substance)			ZBTB20		D003630
PubChem	Ratio Potency (uM)	uM	0.952	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.952	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.131	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	14.960	AR	-	GI(Protien) :
PubChem	Potency	uM	14.125	BLM	-	GI(Protien) :
PubChem	Potency	uM	16.231	BLM	-	GI(Protien) :
PubChem	Potency	uM	28.184	BLM	-	GI(Protien) :
PubChem	Potency	uM	0.251	CBFB	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.758	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	15.849	EHMT2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.477	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.477	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.531	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.562	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.485	ESR1	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	Potency	uM	2.239	HTT	-	GI(Protien) :
PubChem	Potency	uM	4.467	MAPT	-	GI(Protien) :
PubChem	Potency	uM	5.012	MAPT	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.349	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.700	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	5.012	POLK	-	GI(Protien) :
PubChem	Potency	uM	11.917	POLK	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	Potency	uM	0.251	RUNX1	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.021	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.024	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.027	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.038	TDP1	-	GI(Protien) :
PubChem	Potency	uM	11.220	THRB	-	GI(Protien) :
PubChem	Potency	uM	22.387	THRB	-	GI(Protien) :
PubChem	Potency	uM	31.623	THRB	-	GI(Protien) :
PubChem	Potency	uM	44.668	THRB	-	GI(Protien) :
PubChem	Potency	uM	39.811	USP1	-	GI(Protien) :
PubChem	Potency	uM	44.668	USP1	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Potency	nM	10000.000	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	28183.800	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	14125.400	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	16231.300	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	251.200	CBFB	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	15848.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Inhibition	-		HDAC6	-	Target : CHEMBL1865
ChEMBL	Potency	nM	2238.700	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	35481.300	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	25118.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	4466.800	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	5011.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	31622.800	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	28183.800	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	251.200	RUNX1	-	Target : CHEMBL2093862
ChEMBL	Potency	nM	11220.200	THRB	-	Target : CHEMBL1947
ChEMBL	Potency	nM	31622.800	THRB	-	Target : CHEMBL1947
ChEMBL	Potency	nM	22387.200	THRB	-	Target : CHEMBL1947
ChEMBL	Potency	nM	44668.400	THRB	-	Target : CHEMBL1947
ChEMBL	Inhibition	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Inhibition	-		TOP2A	-	Target : CHEMBL1806
ChEMBL	Inhibition	-		TOP2A	-	Target : CHEMBL1806
ChEMBL	Inhibition	-		TOP2A	-	Target : CHEMBL1806

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