Tan Lab | DSigDB

Gene Set: D4 : CTD - Danazol

Collection

D4 : CTD

Chemical Name

Danazol ( From PubChem : MLS003115428 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
337.455 g/mol	1	3	4.221	True

Structure

InChI

InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3

InChIKey

POZRVZJJTULAOH-UHFFFAOYSA-N

Links

Gene (24 / 67)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB11		D003613
CTD	affects(binding)			AR		D003613
CTD	increases(activity)			AR		D003613
CTD	increases(activity)			AR		D003613
CTD	increases(expression)			C3		D003613
CTD	increases(expression)			CFB		D003613
CTD	affects(cotreatment)			CXCL8		D003613
CTD	decreases(reaction)			CXCL8		D003613
CTD	increases(expression)			CXCL8		D003613
CTD	decreases(activity)			HSD11B2		D003613
CTD	decreases(reaction)			HSD11B2		D003613
CTD	affects(cotreatment)			NFKB1		D003613
CTD	decreases(reaction)			NFKB1		D003613
CTD	increases(activity)			NFKB1		D003613
CTD	decreases(reaction)			PRL		D003613
CTD	increases(expression)			PRL		D003613
CTD	increases(expression)			SERPING1		D003613
CTD	decreases(activity)			STS		D003613
CTD	affects(cotreatment)			TNF		D003613
CTD	decreases(reaction)			TNF		D003613
CTD	increases(activity)			TNF		D003613
CTD	increases(expression)			TNF		D003613
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.010	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.016	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.035	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.075	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.221	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.028	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.832	AR	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.668	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.969	ESR1	-	GI(Protien) :
PubChem	Potency	uM	3.162	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.378	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	5.775	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.166	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	6.658	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	47.123	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.966	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.131	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	61.131	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	59.324	HSPB1	-	GI(Protien) :
PubChem	None	uM		MYC	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	5.354	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	None	uM		GNA15	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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