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Gene Set: D4 : CTD - Dacarbazine

Collection D4 : CTD
Chemical Name Dacarbazine ( From PubChem : DACARBAZINE )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
NotNotNotNotNotNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
182.183 g/mol 2 7 -1.7033 True
Structure
InChI InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3,11H,1-2H3,(H2,7,13)/b10-6-
InChIKey OMJKFYKNWZZKTK-POHAHGRESA-N
Links

Gene (27 / 66)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDincreases(response to substance)APEX1
D003606
CTDdecreases(response to substance)APEX1
D003606
CTDincreases(expression)BIRC5
D003606
CTDincreases(activity)CASP3
D003606
CTDincreases(cleavage)CASP3
D003606
CTDincreases(reaction)CASP3
D003606
CTDincreases(activity)CASP8
D003606
CTDincreases(cleavage)CASP8
D003606
CTDincreases(reaction)CASP8
D003606
CTDaffects(cotreatment)CD38
D003606
CTDincreases(expression)CD38
D003606
CTDaffects(cotreatment)CD38
D003606
CTDincreases(expression)CD38
D003606
CTDincreases(expression)CD38
D003606
CTDincreases(reaction)CD38
D003606
CTDaffects(reaction)CD69
D003606
CTDincreases(expression)CD69
D003606
CTDaffects(cotreatment)CD69
D003606
CTDincreases(expression)CD69
D003606
CTDaffects(cotreatment)CD69
D003606
CTDaffects(response to substance)CLU
D003606
CTDdecreases(response to substance)CXCL8
D003606
CTDincreases(expression)CXCL8
D003606
CTDincreases(expression)CXCL8
D003606
CTDincreases(secretion)CXCL8
D003606
CTDincreases(metabolic processing)CYP1A1
D003606
CTDdecreases(reaction)CYP1A1
D003606
CTDincreases(metabolic processing)CYP1A2
D003606
CTDdecreases(reaction)CYP1A2
D003606
CTDdecreases(response to substance)EPO
D003606
CTDaffects(cotreatment)IFNA1
D003606
CTDincreases(expression)IFNA1
D003606
CTDincreases(expression)IFNA1
D003606
CTDincreases(reaction)IFNA1
D003606
CTDaffects(reaction)IFNA2
D003606
CTDincreases(expression)IFNA2
D003606
CTDaffects(cotreatment)IFNA2
D003606
CTDincreases(expression)IFNA2
D003606
CTDaffects(cotreatment)IFNA2
D003606
CTDincreases(expression)IRF1
D003606
CTDincreases(reaction)IRF1
D003606
CTDdecreases(response to substance)MAP3K1
D003606
CTDdecreases(response to substance)MAPK1
D003606
CTDdecreases(response to substance)MAPK3
D003606
CTDdecreases(response to substance)MCL1
D003606
CTDdecreases(activity)MGMT
D003606
CTDdecreases(expression)MGMT
D003606
CTDaffects(response to substance)MGMT
D003606
CTDdecreases(response to substance)MGMT
D003606
CTDdecreases(response to substance)SLC2A1
D003606
CTDincreases(activity)TNFSF10
D003606
CTDincreases(cleavage)TNFSF10
D003606
CTDincreases(reaction)TNFSF10
D003606
CTDincreases(expression)VEGFA
D003606
CTDincreases(expression)VEGFA
D003606
CTDincreases(secretion)VEGFA
D003606
CTDdecreases(response to substance)VEGFA
D003606
PubChem PotencyuM74.978CXCL8-GI(Protien) :
PubChem AC50_uMuM5.340PAX8-GI(Protien) :
PubChem NoneuMPAX8-GI(Protien) :
ChEMBLInhibition-CYP1A2
-Target : CHEMBL3356
ChEMBLInhibition-CYP2C19
-Target : CHEMBL3622
ChEMBLInhibition-CYP2C9
-Target : CHEMBL3397
ChEMBLInhibition-CYP2D6
-Target : CHEMBL289
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
Download gene sets gmt, text, Detailed text
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Aurora, CO 80045, USA

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