Tan Lab | DSigDB

Gene Set: D4 : CTD - Cyproheptadine

Collection

D4 : CTD

Chemical Name

Cyproheptadine ( From PubChem : CYPROHEPTADINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
287.398 g/mol	0	1	4.6358	True

Structure

InChI

InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3

InChIKey

Links

Gene (10 / 25)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			GH1		D003533
CTD	affects(binding)			HTR7		D003533
CTD	decreases(activity)			HTR7		D003533
CTD	decreases(reaction)			HTR7		D003533
CTD	decreases(secretion)			POMC		D003533
CTD	decreases(secretion)			PRL		D003533
CTD	decreases(reaction)			SLC22A2		D003533
CTD	increases(uptake)			SLC22A2		D003533
PubChem	AR Potency (uM)	uM	21.958	AR	-	GI(Protien) :
PubChem	Potency	uM	2.512	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	1.995	DRD1	-	GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :
PubChem	Potency	uM	29.855	TDP1	-	GI(Protien) :
ChEMBL	AC50	nM	2511.890	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3981.070	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	12589.200	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	2511.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3981.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	12589.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	1995.300	DRD1	-	Target : CHEMBL2056

Download gene sets