Tan Lab | DSigDB

Gene Set: D4 : CTD - Coumarins

Collection

D4 : CTD

Chemical Name

Coumarins ( From PubChem : WARFARIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
308.328 g/mol	1	4	3.6096	True

Structure

InChI

InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m1/s1

InChIKey

PJVWKTKQMONHTI-OAHLLOKOSA-N

Links

Gene (35 / 148)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(localization)			AIFM1		D003374
CTD	affects(binding)			ALB		D014859
CTD	decreases(reaction)			ALB		D014859
CTD	affects(binding)			ALB		D014859
CTD	decreases(reaction)			ALB		D014859
CTD	affects(binding)			ALB		D014859
CTD	affects(binding)			ALB		D014859
CTD	decreases(reaction)			ALB		D014859
CTD	increases(expression)			ALOX5AP		D014859
CTD	affects(response to substance)			APOE		D014859
CTD	affects(response to substance)			APOE		D014859
CTD	affects(response to substance)			APOE		D014859
CTD	affects(metabolic processing)			CYP1A2		D014859
CTD	affects(response to substance)			CYP2C18		D014859
CTD	affects(response to substance)			CYP2C19		D014859
CTD	increases(metabolic processing)			CYP2C9		D003374
CTD	increases(reaction)			CYP2C9		D003374
CTD	decreases(reaction)			CYP2C9		D014859
CTD	increases(chemical synthesis)			CYP2C9		D014859
CTD	increases(hydroxylation)			CYP2C9		D014859
CTD	affects(metabolic processing)			CYP2C9		D014859
CTD	decreases(reaction)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	affects(metabolic processing)			CYP2C9		D014859
CTD	affects(metabolic processing)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	affects(hydrolysis)			CYP2C9		D014859
CTD	affects(metabolic processing)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	decreases(hydroxylation)			CYP2C9		D014859
CTD	decreases(metabolic processing)			CYP2C9		D014859
CTD	decreases(response to substance)			CYP2C9		D014859
CTD	increases(response to substance)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	affects(hydroxylation)			CYP2C9		D014859
CTD	affects(metabolic processing)			CYP2C9		D014859
CTD	affects(response to substance)			CYP2C9		D014859
CTD	increases(hydrolysis)			CYP2C9		D014859
CTD	increases(hydroxylation)			CYP2C9		D014859
CTD	increases(metabolic processing)			CYP2C9		D014859
CTD	increases(chemical synthesis)			CYP2C9		D014859
CTD	increases(metabolic processing)			CYP2C9		D014859
CTD	increases(response to substance)			CYP2C9		D014859
CTD	increases(response to substance)			CYP2C9		D014859
CTD	affects(binding)			CYP2C9		D014859
CTD	increases(activity)			CYP2C9		D014859
CTD	increases(expression)			CYP2C9		D014859
CTD	affects(metabolic processing)			CYP2C9		D014859
CTD	decreases(reaction)			CYP2C9		D014859
CTD	decreases(activity)			CYP2C9		D014859
CTD	increases(chemical synthesis)			CYP2D6		D003374
CTD	increases(metabolic processing)			CYP2D6		D003374
CTD	decreases(reaction)			CYP2D6		D003374
CTD	decreases(activity)			CYP2D6		D014859
CTD	affects(metabolic processing)			CYP3A		D014859
CTD	affects(hydroxylation)			CYP3A4		D014859
CTD	affects(metabolic processing)			CYP3A4		D014859
CTD	affects(binding)			CYP3A4		D014859
CTD	increases(activity)			CYP3A4		D014859
CTD	increases(expression)			CYP3A4		D014859
CTD	decreases(activity)			CYP3A4		D014859
CTD	affects(response to substance)			CYP3A5		D014859
CTD	affects(response to substance)			CYP4F2		D014859
CTD	affects(response to substance)			CYP4F2		D014859
CTD	affects(response to substance)			CYP4F2		D014859
CTD	affects(cotreatment)			CYP4F2		D014859
CTD	affects(response to substance)			CYP4F2		D014859
CTD	affects(response to substance)			CYP4F2		D014859
CTD	affects(response to substance)			CYP4F2		D014859
CTD	increases(response to substance)			CYP4F2		D014859
CTD	affects(response to substance)			EPHX1		D014859
CTD	affects(response to substance)			EPHX1		D014859
CTD	affects(response to substance)			EPHX1		D014859
CTD	increases(response to substance)			EPHX1		D014859
CTD	decreases(expression)			ESR1		D003374
CTD	affects(response to substance)			F2		D014859
CTD	decreases(expression)			F2		D014859
CTD	increases(reaction)			F2		D014859
CTD	affects(response to substance)			F5		D014859
CTD	affects(response to substance)			F7		D014859
CTD	affects(response to substance)			F7		D014859
CTD	decreases(expression)			F7		D014859
CTD	increases(reaction)			F7		D014859
CTD	affects(response to substance)			GGCX		D014859
CTD	decreases(response to substance)			GGCX		D014859
CTD	affects(response to substance)			GGCX		D014859
CTD	affects(response to substance)			GGCX		D014859
CTD	increases(response to substance)			GGCX		D014859
CTD	decreases(reaction)			IL1B		D014859
CTD	decreases(response to substance)			IL1B		D014859
CTD	affects(binding)			NR1I2		D014859
CTD	increases(activity)			NR1I2		D014859
CTD	increases(expression)			NR1I2		D014859
CTD	affects(binding)			ORM1		D014859
CTD	decreases(reaction)			ORM1		D014859
CTD	affects(response to substance)			ORM1		D014859
CTD	affects(response to substance)			ORM1		D014859
CTD	increases(response to substance)			ORM1		D014859
CTD	increases(hydrolysis)			PON1		D003374
CTD	increases(hydrolysis)			PON2		D003374
CTD	increases(hydrolysis)			PON3		D003374
CTD	affects(response to substance)			PROC		D014859
CTD	increases(response to substance)			PROC		D014859
CTD	affects(response to substance)			PROS1		D014859
CTD	affects(response to substance)			PRSS53		D014859
CTD	increases(expression)			SERPINC1		D014859
CTD	increases(degradation)			TP53		D014859
CTD	increases(metabolic processing)			UGT1A1		D014859
CTD	increases(chemical synthesis)			UGT1A1		D014859
CTD	increases(metabolic processing)			UGT1A10		D014859
CTD	increases(chemical synthesis)			UGT1A10		D014859
CTD	affects(activity)			VKORC1		D003374
CTD	affects(cotreatment)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	decreases(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	decreases(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	decreases(metabolic processing)			VKORC1		D014859
CTD	decreases(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	increases(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(metabolic processing)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	affects(response to substance)			VKORC1		D014859
CTD	increases(response to substance)			VKORC1		D014859
CTD	increases(response to substance)			VKORC1		D014859
CTD	decreases(reaction)			VKORC1		D014859
CTD	increases(reduction)			VKORC1		D014859
CTD	decreases(activity)			VKORC1		D014859
CTD	affects(reaction)			VKORC1L1		D014859
CTD	increases(reduction)			VKORC1L1		D014859
CTD	decreases(reaction)			VKORC1L1		D014859
CTD	increases(metabolic processing)			VKORC1L1		D014859
PubChem	Ratio Potency (uM)	uM	9.086	PPARG	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.008	PPARG	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	11.100	PPARG	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.801	PPARG	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.089	PPARG	-	GI(Protien) :
ChEMBL	Activity	-		ALB	-	Target : CHEMBL3253

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