Tan Lab | DSigDB

Gene Set: D4 : CTD - Corticosterone

Collection

D4 : CTD

Chemical Name

Corticosterone ( From PubChem : CORTICOSTERONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
346.461 g/mol	2	4	2.6667	True

Structure

InChI

InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChIKey

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Links

Gene (15 / 68)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCG2		D003345
CTD	affects(binding)			AR		D003345
CTD	increases(activity)			AR		D003345
CTD	decreases(reaction)			AR		D003345
CTD	increases(activity)			AR		D003345
CTD	increases(activity)			AR		D003345
CTD	increases(chemical synthesis)			CYP11B1		D003345
CTD	affects(metabolic processing)			CYP11B2		D003345
CTD	increases(chemical synthesis)			CYP11B2		D003345
CTD	increases(hydroxylation)			CYP11B2		D003345
CTD	affects(binding)			CYP3A4		D003345
CTD	increases(expression)			CYP3A4		D003345
CTD	affects(binding)			CYP3A4		D003345
CTD	increases(expression)			CYP3A4		D003345
CTD	increases(reaction)			CYP3A4		D003345
CTD	increases(response to substance)			IL1B		D003345
CTD	increases(secretion)			IL1B		D003345
CTD	affects(binding)			NCOA1		D003345
CTD	increases(expression)			NCOA1		D003345
CTD	increases(reaction)			NCOA1		D003345
CTD	affects(binding)			NR1I2		D003345
CTD	increases(activity)			NR1I2		D003345
CTD	affects(binding)			NR1I2		D003345
CTD	increases(expression)			NR1I2		D003345
CTD	increases(reaction)			NR1I2		D003345
CTD	affects(binding)			NR3C1		D003345
CTD	increases(activity)			NR3C1		D003345
CTD	affects(binding)			NR3C1		D003345
CTD	affects(binding)			NR3C2		D003345
CTD	decreases(expression)			SLC1A2		D003345
CTD	decreases(reaction)			SLC1A2		D003345
CTD	increases(expression)			SLC1A2		D003345
CTD	increases(reaction)			SLC1A2		D003345
CTD	affects(transport)			SLC22A11		D003345
CTD	decreases(reaction)			SLC22A11		D003345
CTD	decreases(reaction)			SLC22A3		D003345
CTD	increases(uptake)			SLC22A3		D003345
CTD	decreases(reaction)			SLC22A3		D003345
CTD	increases(uptake)			SLC22A3		D003345
CTD	decreases(activity)			SLC22A3		D003345
PubChem	Potency-Replicate_1	uM	0.109	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.122	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.155	AR	-	GI(Protien) :
PubChem	Potency	uM	0.224	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.275	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.292	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.312	AR	-	GI(Protien) :
PubChem	Potency	uM	0.316	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.376	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.601	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.882	AR	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	Potency	uM	0.411	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	1.300	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	6.513	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	68.729	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.069	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.084	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.123	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.138	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.169	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.262	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.390	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.674	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
ChEMBL	Potency	nM	6513.100	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	410.900	NFE2L2	-	Target : CHEMBL1075094

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