Tan Lab | DSigDB

Gene Set: D4 : CTD - Clonidine

Collection

D4 : CTD

Chemical Name

Clonidine ( From PubChem : CLONIDINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
230.094 g/mol	2	3	2.2019	True

Structure

InChI

InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)

InChIKey

GJSURZIOUXUGAL-UHFFFAOYSA-N

Links

Gene (25 / 70)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			ADRA2A		D003000
CTD	increases(activity)			ADRA2A		D003000
CTD	affects(binding)			ADRA2B		D003000
CTD	increases(activity)			ADRA2B		D003000
CTD	affects(binding)			ADRA2C		D003000
CTD	increases(activity)			ADRA2C		D003000
CTD	decreases(expression)			APOA1		D003000
CTD	decreases(expression)			APOA2		D003000
CTD	decreases(reaction)			CCL2		D003000
CTD	increases(expression)			CCL2		D003000
CTD	decreases(reaction)			CXCL8		D003000
CTD	increases(secretion)			CXCL8		D003000
CTD	decreases(reaction)			CXCL8		D003000
CTD	increases(expression)			CXCL8		D003000
CTD	increases(expression)			GH1		D003000
CTD	increases(expression)			GH1		D003000
CTD	increases(secretion)			GH1		D003000
CTD	decreases(reaction)			GH1		D003000
CTD	increases(expression)			GH1		D003000
CTD	increases(secretion)			IL10		D003000
CTD	affects(binding)			IL1B		D003000
CTD	decreases(reaction)			IL1B		D003000
CTD	increases(activity)			IL1B		D003000
CTD	increases(secretion)			IL1B		D003000
CTD	decreases(secretion)			INS		D003000
CTD	affects(binding)			NFKB1		D003000
CTD	decreases(reaction)			NFKB1		D003000
CTD	increases(activity)			NFKB1		D003000
CTD	affects(localization)			NFKB1		D003000
CTD	decreases(reaction)			NFKB1		D003000
CTD	increases(activity)			NFKB1		D003000
CTD	decreases(expression)			PDCD4		D003000
CTD	increases(expression)			POMC		D003000
CTD	increases(expression)			POMC		D003000
CTD	increases(response to substance)			POMC		D003000
CTD	increases(expression)			PRL		D003000
CTD	affects(binding)			RELA		D003000
CTD	decreases(reaction)			RELA		D003000
CTD	increases(activity)			RELA		D003000
CTD	affects(localization)			RELA		D003000
CTD	decreases(reaction)			RELA		D003000
CTD	increases(activity)			RELA		D003000
CTD	affects(cotreatment)			REN		D003000
CTD	decreases(expression)			REN		D003000
CTD	decreases(activity)			REN		D003000
CTD	decreases(expression)			REN		D003000
CTD	increases(activity)			REN		D003000
CTD	decreases(reaction)			SLC22A1		D003000
CTD	increases(transport)			SLC22A1		D003000
CTD	decreases(reaction)			SLC22A2		D003000
CTD	increases(transport)			SLC22A2		D003000
CTD	decreases(reaction)			SLC22A2		D003000
CTD	increases(uptake)			SLC22A2		D003000
CTD	decreases(reaction)			SLC22A3		D003000
CTD	increases(transport)			SLC22A3		D003000
CTD	increases(expression)			TNFAIP3		D003000
CTD	increases(expression)			TPD52		D003000
PubChem	Potency	uM	5.012	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Potency	nM	5011.900	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	5011.870	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	7943.280	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	7943.300	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	10000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	10000.000	CYP2D6	-	Target : CHEMBL289

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