Tan Lab | DSigDB

Gene Set: D4 : CTD - Clomipramine

Collection

D4 : CTD

Chemical Name

Clomipramine ( From PubChem : CLOMIPRAMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
314.852 g/mol	0	1	4.5934	True

Structure

InChI

InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3

InChIKey

GDLIGKIOYRNHDA-UHFFFAOYSA-N

Links

Gene (42 / 73)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			AP1S1		D002997
CTD	increases(expression)			ASNS		D002997
CTD	increases(expression)			C10ORF10		D002997
CTD	increases(activity)			CASP3		D002997
CTD	increases(activity)			CASP3		D002997
CTD	increases(cleavage)			CASP3		D002997
CTD	increases(reaction)			CASP3		D002997
CTD	increases(activity)			CASP7		D002997
CTD	increases(reaction)			CASP7		D002997
CTD	decreases(expression)			CAT		D002997
CTD	increases(expression)			FABP1		D002997
CTD	decreases(expression)			FNDC4		D002997
CTD	increases(expression)			FNDC4		D002997
CTD	increases(expression)			GDPD3		D002997
CTD	decreases(activity)			GSTP1		D002997
CTD	increases(expression)			HMGCS1		D002997
CTD	increases(expression)			HPN		D002997
CTD	affects(binding)			HTR2C		D002997
CTD	affects(cotreatment)			IL1A		D002997
CTD	increases(response to substance)			IL1A		D002997
CTD	affects(cotreatment)			IL6		D002997
CTD	increases(response to substance)			IL6		D002997
CTD	increases(expression)			INHBE		D002997
CTD	decreases(reaction)			KCNH2		D002997
CTD	increases(transport)			KCNH2		D002997
CTD	increases(expression)			LSS		D002997
CTD	increases(expression)			NR0B2		D002997
CTD	increases(expression)			NUPR1		D002997
CTD	increases(cleavage)			PARP1		D002997
CTD	increases(expression)			PHYH		D002997
CTD	affects(secretion)			PRL		D002997
CTD	increases(expression)			PRL		D002997
CTD	increases(secretion)			PRL		D002997
CTD	decreases(reaction)			PRL		D002997
CTD	increases(expression)			PROC		D002997
CTD	increases(expression)			SCD		D002997
CTD	increases(expression)			SERPINA3		D002997
CTD	decreases(reaction)			SLC22A2		D002997
CTD	increases(uptake)			SLC22A2		D002997
CTD	decreases(expression)			SLC2A3		D002997
CTD	affects(binding)			SLC6A4		D002997
CTD	decreases(activity)			SLC6A4		D002997
CTD	affects(secretion)			SLC6A4		D002997
CTD	decreases(reaction)			SLC6A4		D002997
CTD	increases(activity)			SREBF1		D002997
CTD	increases(cleavage)			SREBF1		D002997
CTD	increases(activity)			SREBF2		D002997
CTD	increases(cleavage)			SREBF2		D002997
CTD	decreases(expression)			TAGLN		D002997
CTD	affects(cotreatment)			TNF		D002997
CTD	increases(response to substance)			TNF		D002997
CTD	increases(expression)			WIPI1		D002997
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	1.995	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	2.512	DRD1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.847	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.882	PPARG	-	GI(Protien) :
PubChem	Potency	uM	16.789	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.715	TDP1	-	GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :
PubChem	Potency	uM	19.953	TP53	-	GI(Protien) :
ChEMBL	AC50	nM	15848.900	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	5011.870	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1995.260	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	1995.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	2511.900	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	19952.600	TP53	-	Target : CHEMBL4096

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