Tan Lab | DSigDB

Gene Set: D4 : CTD - Clofibrate

Collection

D4 : CTD

Chemical Name

Clofibrate ( From PubChem : CLOFIBRATE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
242.699 g/mol	0	3	3.0605	True

Structure

InChI

InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

InChIKey

KNHUKKLJHYUCFP-UHFFFAOYSA-N

Links

Gene (51 / 109)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(expression)			ABCA1		D002994
CTD	increases(expression)			ABCA1		D002994
CTD	affects(reaction)			ABCA1		D002994
CTD	decreases(activity)			ABCB11		D002994
CTD	increases(expression)			ALB		D002994
CTD	increases(secretion)			APOA1		D002994
CTD	increases(reaction)			APOA1		D002994
CTD	decreases(reaction)			BSG		D002994
CTD	increases(expression)			BSG		D002994
CTD	affects(expression)			CAV1		D002994
CTD	decreases(reaction)			CCL2		D002994
CTD	increases(expression)			CCL2		D002994
CTD	decreases(reaction)			CCL2		D002994
CTD	increases(secretion)			CCL2		D002994
CTD	decreases(expression)			CCNA2		D002994
CTD	decreases(expression)			CCND2		D002994
CTD	increases(expression)			CD14		D002994
CTD	decreases(expression)			CDK1		D002994
CTD	decreases(reaction)			CDK1		D002994
CTD	decreases(expression)			CDK4		D002994
CTD	decreases(reaction)			CDK4		D002994
CTD	decreases(expression)			CP		D002994
CTD	increases(expression)			CPT1A		D002994
CTD	affects(binding)			CREBBP		D002994
CTD	decreases(reaction)			CREBBP		D002994
CTD	affects(response to substance)			CREBBP		D002994
CTD	decreases(expression)			CREBBP		D002994
CTD	decreases(reaction)			CX3CL1		D002994
CTD	increases(expression)			CX3CL1		D002994
CTD	increases(expression)			CYP1A1		D002994
CTD	increases(expression)			CYP4A11		D002994
CTD	affects(binding)			EGFR		D002994
CTD	decreases(reaction)			EGFR		D002994
CTD	decreases(expression)			EGFR		D002994
CTD	affects(secretion)			GCG		D002994
CTD	decreases(activity)			HIF1A		D002994
CTD	decreases(expression)			HMGCR		D002994
CTD	affects(cotreatment)			IFNG		D002994
CTD	decreases(reaction)			IFNG		D002994
CTD	increases(abundance)			IFNG		D002994
CTD	increases(expression)			IFNG		D002994
CTD	affects(cotreatment)			IL1B		D002994
CTD	decreases(reaction)			IL1B		D002994
CTD	increases(abundance)			IL1B		D002994
CTD	increases(expression)			IL1B		D002994
CTD	affects(secretion)			INS		D002994
CTD	decreases(secretion)			INS		D002994
CTD	decreases(reaction)			JUN		D002994
CTD	increases(expression)			JUN		D002994
CTD	increases(activity)			LPL		D002994
CTD	increases(expression)			LPL		D002994
CTD	decreases(expression)			MAPK3		D002994
CTD	decreases(reaction)			MAPK3		D002994
CTD	decreases(secretion)			MMP9		D002994
CTD	decreases(expression)			MYB		D002994
CTD	decreases(expression)			MYC		D002994
CTD	decreases(reaction)			MYC		D002994
CTD	affects(binding)			NCOA1		D002994
CTD	decreases(reaction)			NCOA1		D002994
CTD	affects(response to substance)			NCOA1		D002994
CTD	decreases(expression)			NCOA1		D002994
CTD	decreases(reaction)			NOS2		D002994
CTD	increases(methylation)			NOS2		D002994
CTD	affects(cotreatment)			NOS2		D002994
CTD	decreases(reaction)			NOS2		D002994
CTD	increases(expression)			NOS2		D002994
CTD	affects(localization)			PCTP		D002994
CTD	affects(expression)			PLG		D002994
CTD	affects(binding)			PPARA		D002994
CTD	increases(activity)			PPARA		D002994
CTD	increases(activity)			PPARA		D002994
CTD	affects(binding)			PPARA		D002994
CTD	increases(activity)			PPARA		D002994
CTD	increases(expression)			PPARA		D002994
CTD	increases(expression)			PPARA		D002994
CTD	affects(reaction)			PPARA		D002994
CTD	increases(expression)			PPARA		D002994
CTD	affects(binding)			PPARD		D002994
CTD	increases(activity)			PPARD		D002994
CTD	affects(binding)			PPARG		D002994
CTD	increases(activity)			PPARG		D002994
CTD	decreases(reaction)			RELA		D002994
CTD	increases(expression)			RELA		D002994
CTD	affects(binding)			RXRA		D002994
CTD	increases(activity)			RXRA		D002994
CTD	decreases(expression)			SERPINC1		D002994
CTD	decreases(expression)			SOD1		D002994
CTD	increases(expression)			TF		D002994
CTD	decreases(reaction)			TGFB1		D002994
CTD	increases(expression)			TGFB1		D002994
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.603	ESR1	-	GI(Protien) :
ChEMBL	Activity	-		CDK1	-	Target : CHEMBL308
ChEMBL	Activity	-		CDK1	-	Target : CHEMBL308
ChEMBL	Inhibition	-		CDK1	-	Target : CHEMBL308
ChEMBL	Activity	-		CFL1	-	Target : CHEMBL1075129
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	12589.200	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	CYP3A4	-	Target : CHEMBL340
ChEMBL	Activity	-		JUN	-	Target : CHEMBL4977
ChEMBL	Activity	-		JUN	-	Target : CHEMBL4977
ChEMBL	Activity	-		TP53	-	Target : CHEMBL4096
ChEMBL	Inhibition	-		TP53	-	Target : CHEMBL4096

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