Tan Lab | DSigDB

Gene Set: D4 : CTD - Cholecalciferol

Collection

D4 : CTD

Chemical Name

Cholecalciferol ( From PubChem : CHOLECALCIFEROL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
384.638 g/mol	1	1	7.619	False(3/4)

Structure

InChI

InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3

InChIKey

QYSXJUFSXHHAJI-UHFFFAOYSA-N

Links

Gene (104 / 238)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ABCC4		D002762
CTD	affects(expression)			ADGRG1		D014807
CTD	affects(expression)			ANKRD22		D014807
CTD	affects(expression)			ANXA2		D014807
CTD	increases(expression)			AQP9		D014807
CTD	increases(phosphorylation)			BAD		D002762
CTD	affects(binding)			BAD		D002762
CTD	decreases(reaction)			BAD		D002762
CTD	increases(expression)			BCL2		D002762
CTD	affects(binding)			BCL2L1		D002762
CTD	decreases(reaction)			BCL2L1		D002762
CTD	increases(reaction)			BCL2L1		D002762
CTD	increases(expression)			BCL2L1		D002762
CTD	increases(phosphorylation)			BCL2L1		D002762
CTD	affects(binding)			BECN1		D002762
CTD	decreases(reaction)			BECN1		D002762
CTD	increases(reaction)			BECN1		D002762
CTD	affects(binding)			BECN1		D002762
CTD	decreases(reaction)			BECN1		D002762
CTD	increases(reaction)			BECN1		D002762
CTD	increases(expression)			BECN1		D002762
CTD	decreases(reaction)			BGLAP		D014807
CTD	increases(expression)			BGLAP		D014807
CTD	affects(cotreatment)			BGLAP		D002762
CTD	increases(expression)			BGLAP		D002762
CTD	increases(secretion)			BGLAP		D002762
CTD	decreases(expression)			CASP9		D002762
CTD	decreases(expression)			CCNE1		D002762
CTD	increases(expression)			CD14		D014807
CTD	increases(reaction)			CD14		D014807
CTD	affects(cotreatment)			CD14		D002762
CTD	increases(expression)			CD14		D002762
CTD	increases(expression)			CD14		D002762
CTD	decreases(reaction)			CD14		D002762
CTD	decreases(reaction)			CD14		D002762
CTD	affects(expression)			CD300A		D014807
CTD	increases(expression)			CDA		D002762
CTD	affects(binding)			CDK2		D002762
CTD	increases(reaction)			CDK2		D002762
CTD	decreases(activity)			CDK2		D002762
CTD	decreases(phosphorylation)			CDK2		D002762
CTD	decreases(expression)			CDKN1A		D002762
CTD	affects(binding)			CDKN1B		D002762
CTD	increases(reaction)			CDKN1B		D002762
CTD	decreases(degradation)			CDKN1B		D002762
CTD	increases(expression)			CDKN1B		D002762
CTD	increases(expression)			CDKN2D		D002762
CTD	affects(expression)			CSTF2T		D014807
CTD	decreases(reaction)			CXCL8		D014807
CTD	increases(secretion)			CXCL8		D014807
CTD	decreases(reaction)			CYP24A1		D014807
CTD	increases(expression)			CYP24A1		D014807
CTD	affects(binding)			CYP24A1		D014807
CTD	decreases(reaction)			CYP24A1		D014807
CTD	increases(reaction)			CYP24A1		D014807
CTD	increases(expression)			CYP24A1		D014807
CTD	decreases(reaction)			CYP24A1		D002762
CTD	increases(expression)			CYP24A1		D002762
CTD	increases(expression)			CYP24A1		D002762
CTD	increases(expression)			CYP2B6		D002762
CTD	increases(expression)			CYP2C9		D002762
CTD	decreases(activity)			CYP2C9		D002762
CTD	decreases(activity)			CYP2D6		D002762
CTD	increases(expression)			CYP3A4		D014807
CTD	increases(expression)			CYP3A4		D002762
CTD	decreases(activity)			CYP3A4		D002762
CTD	increases(expression)			CYP3A4		D002762
CTD	increases(hydroxylation)			CYP3A4		D002762
CTD	decreases(reaction)			CYP3A4		D002762
CTD	increases(reaction)			CYP3A4		D002762
CTD	increases(hydroxylation)			CYP3A5		D002762
CTD	affects(expression)			F13A1		D014807
CTD	affects(metabolic processing)			FGF23		D014807
CTD	increases(metabolic processing)			FGF23		D014807
CTD	affects(abundance)			FGF23		D014807
CTD	affects(reaction)			FGF23		D014807
CTD	increases(expression)			FOS		D014807
CTD	affects(expression)			GAS7		D014807
CTD	affects(binding)			GC		D014807
CTD	decreases(reaction)			IFNG		D002762
CTD	increases(secretion)			IFNG		D002762
CTD	increases(expression)			IL10		D002762
CTD	increases(reaction)			IL10		D002762
CTD	increases(expression)			IL6		D002762
CTD	increases(expression)			ITGAM		D014807
CTD	increases(reaction)			ITGAM		D014807
CTD	increases(expression)			ITGAM		D014807
CTD	increases(reaction)			ITGAM		D014807
CTD	affects(cotreatment)			ITGAM		D002762
CTD	increases(expression)			ITGAM		D002762
CTD	increases(expression)			ITGAX		D014807
CTD	increases(reaction)			ITGAX		D014807
CTD	affects(cotreatment)			ITGAX		D002762
CTD	increases(expression)			ITGAX		D002762
CTD	increases(expression)			ITGB2		D014807
CTD	increases(expression)			JUN		D014807
CTD	affects(expression)			KIT		D014807
CTD	affects(abundance)			KL		D014807
CTD	affects(reaction)			KL		D014807
CTD	affects(expression)			LRRC25		D014807
CTD	affects(expression)			LY75		D014807
CTD	affects(expression)			MCEMP1		D014807
CTD	affects(expression)			ME1		D014807
CTD	decreases(activity)			MMP2		D002762
CTD	increases(reaction)			MMP2		D002762
CTD	affects(expression)			MS4A6A		D014807
CTD	decreases(expression)			MTOR		D002762
CTD	increases(expression)			MTOR		D002762
CTD	increases(reaction)			MTOR		D002762
CTD	decreases(response to substance)			MTOR		D002762
CTD	affects(binding)			NCOA1		D014807
CTD	increases(reaction)			NCOA1		D014807
CTD	affects(binding)			NCOR2		D014807
CTD	decreases(reaction)			NCOR2		D014807
CTD	increases(reaction)			NCOR2		D014807
CTD	decreases(expression)			ND4		D002762
CTD	increases(activity)			NR1I2		D014807
CTD	affects(expression)			PARP1		D002762
CTD	affects(binding)			PIK3C3		D002762
CTD	decreases(reaction)			PIK3C3		D002762
CTD	increases(reaction)			PIK3C3		D002762
CTD	increases(expression)			PIK3C3		D002762
CTD	affects(binding)			PIK3C3		D002762
CTD	decreases(reaction)			PIK3C3		D002762
CTD	increases(reaction)			PIK3C3		D002762
CTD	affects(expression)			PIP5K1B		D014807
CTD	affects(expression)			PLD4		D014807
CTD	affects(cotreatment)			PML		D002762
CTD	decreases(reaction)			PML		D002762
CTD	increases(expression)			PML		D002762
CTD	affects(expression)			PPARG		D014807
CTD	decreases(expression)			PTH		D014807
CTD	affects(cotreatment)			PTH		D002762
CTD	decreases(expression)			PTH		D002762
CTD	decreases(expression)			PTH		D002762
CTD	increases(expression)			PXN		D002762
CTD	decreases(reaction)			RAF1		D002762
CTD	increases(expression)			RAF1		D002762
CTD	increases(response to substance)			RAF1		D002762
CTD	affects(cotreatment)			RARA		D002762
CTD	decreases(reaction)			RARA		D002762
CTD	increases(expression)			RARA		D002762
CTD	increases(expression)			RB1		D002762
CTD	decreases(reaction)			RB1		D002762
CTD	affects(expression)			RGS1		D014807
CTD	decreases(phosphorylation)			RPS6KB1		D002762
CTD	affects(cotreatment)			RUNX2		D002762
CTD	increases(expression)			RUNX2		D002762
CTD	affects(binding)			RXRA		D014807
CTD	increases(reaction)			RXRA		D014807
CTD	affects(binding)			RXRA		D002762
CTD	affects(cotreatment)			RXRA		D002762
CTD	increases(reaction)			RXRA		D002762
CTD	increases(expression)			SFTPB		D014807
CTD	affects(expression)			SLC26A11		D014807
CTD	affects(expression)			SLC2A14		D014807
CTD	increases(expression)			SLC46A1		D002762
CTD	affects(binding)			SLCO1A2		D002762
CTD	increases(expression)			SLCO1A2		D002762
CTD	affects(cotreatment)			SLCO1A2		D002762
CTD	increases(reaction)			SLCO1A2		D002762
CTD	affects(binding)			SLCO1A2		D002762
CTD	increases(expression)			SLCO1A2		D002762
CTD	increases(reaction)			SLCO1A2		D002762
CTD	affects(reaction)			SLCO1A2		D002762
CTD	affects(cotreatment)			SPARC		D002762
CTD	increases(expression)			SPARC		D002762
CTD	affects(cotreatment)			SPP1		D002762
CTD	increases(expression)			SPP1		D002762
CTD	affects(expression)			SULF2		D014807
CTD	affects(cotreatment)			TAZ		D002762
CTD	increases(expression)			TAZ		D002762
CTD	affects(cotreatment)			TGFB1		D002762
CTD	increases(expression)			TGFB1		D002762
CTD	decreases(reaction)			TGFB1		D002762
CTD	increases(expression)			TGM2		D014807
CTD	increases(reaction)			TGM2		D014807
CTD	decreases(expression)			TLR2		D014807
CTD	decreases(expression)			TLR4		D014807
CTD	affects(cotreatment)			TNFRSF11B		D002762
CTD	increases(expression)			TNFRSF11B		D002762
CTD	affects(expression)			TNFSF10		D014807
CTD	decreases(reaction)			TNFSF11		D014807
CTD	increases(expression)			TNFSF11		D014807
CTD	increases(expression)			TNFSF11		D002762
CTD	affects(cotreatment)			TNFSF11		D002762
CTD	decreases(reaction)			TNFSF11		D002762
CTD	increases(expression)			TXNIP		D002762
CTD	affects(expression)			UBE2E1		D014807
CTD	affects(binding)			VDR		D014807
CTD	decreases(reaction)			VDR		D014807
CTD	increases(reaction)			VDR		D014807
CTD	affects(activity)			VDR		D014807
CTD	affects(binding)			VDR		D002762
CTD	increases(activity)			VDR		D002762
CTD	affects(binding)			VDR		D002762
CTD	increases(expression)			VDR		D002762
CTD	affects(cotreatment)			VDR		D002762
CTD	increases(reaction)			VDR		D002762
CTD	increases(expression)			VDR		D002762
CTD	increases(reaction)			VDR		D002762
CTD	affects(reaction)			VDR		D002762
CTD	decreases(expression)			VIM		D002762
CTD	increases(reaction)			VIM		D002762
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency	uM	15.849	ALOX15	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	19.317	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	67.962	AR	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	15.849	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	15.849	ESR1	-	GI(Protien) :
PubChem	Potency	uM	23.715	GMNN	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	51.398	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	22.387	MAPT	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	20.682	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.492	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	23.710	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.444	PPARG	-	GI(Protien) :
PubChem	Potency	uM	25.119	VDR	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	23.715	TDP1	-	GI(Protien) :
PubChem	Potency	uM	26.609	TDP1	-	GI(Protien) :
PubChem	None	uM		NR1H2	-	GI(Protien) :
PubChem	None	uM		NR2F1	-	GI(Protien) :
PubChem	None	uM		NR4A2	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		RARA	-	GI(Protien) :
PubChem	None	uM		RXRA	-	GI(Protien) :
PubChem	None	uM		RXRG	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	31622.800	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	22387.200	MAPT	-	Target : CHEMBL1293224

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