Tan Lab | DSigDB

Gene Set: D4 : CTD - Chlorpropamide

Collection

D4 : CTD

Chemical Name

Chlorpropamide ( From PubChem : CHLORPROPAMIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
276.74 g/mol	2	5	3.6005	True

Structure

InChI

InChI=1S/C10H13ClN2O3S/c1-2-7-12-10(14)13-17(15,16)9-5-3-8(11)4-6-9/h3-6H,2,7H2,1H3,(H2,12,13,14)

InChIKey

Links

Gene (11 / 18)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			ABCC8		D002747
CTD	decreases(response to substance)			ABCC8		D002747
CTD	decreases(secretion)			AVP		D002747
CTD	increases(expression)			FOS		D002747
CTD	decreases(reaction)			INS		D002747
CTD	decreases(secretion)			INS		D002747
CTD	decreases(expression)			INS		D002747
CTD	increases(expression)			INS		D002747
CTD	affects(cotreatment)			KCNJ11		D002747
CTD	decreases(response to substance)			KCNJ11		D002747
PubChem	Potency	uM	0.447	NFKB1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	446.700	NFKB1	-	Target : CHEMBL3251

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