Tan Lab | DSigDB

Gene Set: D4 : CTD - Chlordan

Collection

D4 : CTD

Chemical Name

Chlordan ( From PubChem : CHLORDANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
409.779 g/mol	0	0	5.6828	False(3/4)

Structure

InChI

InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2

InChIKey

BIWJNBZANLAXMG-UHFFFAOYSA-N

Links

Gene (20 / 56)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCB1		D002706
CTD	decreases(activity)			ABCC2		D002706
CTD	increases(expression)			ABCC2		D002706
CTD	decreases(activity)			ABCG2		D002706
CTD	increases(expression)			ABCG2		D002706
CTD	affects(cotreatment)			AR		D002706
CTD	decreases(reaction)			AR		D002706
CTD	increases(expression)			AR		D002706
CTD	decreases(reaction)			AR		D002706
CTD	increases(activity)			AR		D002706
CTD	increases(activity)			CYP19A1		D002706
CTD	increases(expression)			CYP19A1		D002706
CTD	decreases(reaction)			CYP26A1		D002706
CTD	increases(expression)			CYP26A1		D002706
CTD	increases(expression)			CYP2B6		D002706
CTD	increases(expression)			CYP3A4		D002706
CTD	increases(reaction)			CYP3A4		D002706
CTD	increases(expression)			CYP3A4		D002706
CTD	increases(activity)			ESR1		D002706
CTD	increases(activity)			ESR1		D002706
CTD	affects(cotreatment)			ESR1		D002706
CTD	increases(expression)			ESR1		D002706
CTD	affects(binding)			ESR1		D002706
CTD	affects(cotreatment)			ESR1		D002706
CTD	decreases(reaction)			ESR1		D002706
CTD	affects(binding)			ESR2		D002706
CTD	increases(activity)			ESR2		D002706
CTD	increases(activity)			ESR2		D002706
CTD	affects(binding)			ESRRA		D002706
CTD	decreases(activity)			ESRRA		D002706
CTD	decreases(activity)			ESRRA		D002706
CTD	affects(binding)			NR1I2		D002706
CTD	increases(activity)			NR1I2		D002706
CTD	increases(expression)			NR1I2		D002706
CTD	increases(reaction)			NR1I2		D002706
CTD	increases(activity)			NR1I2		D002706
CTD	affects(binding)			RARB		D002706
CTD	decreases(reaction)			RARB		D002706
CTD	increases(expression)			RARB		D002706
CTD	affects(binding)			RARG		D002706
CTD	decreases(reaction)			RARG		D002706
CTD	increases(expression)			RARG		D002706
CTD	decreases(expression)			RB1		D002706
CTD	decreases(expression)			SLC10A1		D002706
CTD	decreases(activity)			SLC22A1		D002706
PubChem	Potency-Replicate_1	uM	48.828	AR	-	GI(Protien) :
PubChem	Potency	uM	42.163	CXCL8	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	68.380	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	54.753	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.786	ESR1	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	14.125	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	39.811	TSHR	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	39810.700	TSHR	-	Target : CHEMBL1963

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