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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone

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Collection	D4 : CTD
Chemical Name	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone ( From PubChem : FCCP )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 254.168 g/mol 1 5 2.47326 True
Structure
InChI	InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
InChIKey	BMZRVOVNUMQTIN-UHFFFAOYSA-N
Links
Gene (64 / 77) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) ADCK3 D002259 CTD decreases(expression) BAX D002259 CTD decreases(expression) BCL2L1 D002259 CTD decreases(expression) CASP8 D002259 CTD decreases(expression) CAT D002259 CTD decreases(expression) CCNC D002259 CTD decreases(expression) CCND1 D002259 CTD decreases(expression) CCNG1 D002259 CTD affects(binding) CDK4 D002259 CTD increases(reaction) CDK4 D002259 CTD affects(binding) CDKN1B D002259 CTD increases(reaction) CDKN1B D002259 CTD increases(expression) CDKN1B D002259 CTD decreases(activity) COMT D002259 CTD decreases(abundance) COMT D002259 CTD decreases(expression) COQ10A D002259 CTD increases(expression) COQ2 D002259 CTD decreases(expression) COQ3 D002259 CTD increases(expression) COQ4 D002259 CTD increases(expression) COQ5 D002259 CTD increases(expression) COQ6 D002259 CTD increases(expression) COQ7 D002259 CTD increases(expression) COQ9 D002259 CTD increases(expression) CYP1A1 D002259 CTD decreases(expression) DDB1 D002259 CTD decreases(expression) DNAJA1 D002259 CTD decreases(expression) EGR1 D002259 CTD decreases(expression) EPHX2 D002259 CTD decreases(expression) GADD45A D002259 CTD increases(expression) GDF15 D002259 CTD decreases(expression) GSR D002259 CTD decreases(expression) GSTM3 D002259 CTD increases(expression) HMOX1 D002259 CTD decreases(expression) HMOX2 D002259 CTD decreases(expression) HSF1 D002259 CTD decreases(expression) HSP90AA1 D002259 CTD decreases(expression) HSPA1A D002259 CTD decreases(expression) HSPA1B D002259 CTD decreases(expression) HSPA1L D002259 CTD decreases(expression) HSPA2 D002259 CTD decreases(expression) HSPA4 D002259 CTD decreases(expression) HSPA8 D002259 CTD increases(expression) HSPE1 D002259 CTD decreases(expression) IL18 D002259 CTD decreases(expression) IL1A D002259 CTD decreases(expression) MDM2 D002259 CTD decreases(expression) MT1A D002259 CTD decreases(expression) MT1H D002259 CTD decreases(expression) MT2A D002259 CTD decreases(expression) NFKBIA D002259 CTD decreases(expression) PDSS1 D002259 CTD increases(expression) PDSS2 D002259 CTD increases(expression) PTGS2 D002259 CTD decreases(expression) RAD23A D002259 CTD decreases(expression) RPL13A D002259 CTD decreases(expression) SERPINE1 D002259 CTD increases(expression) SOD2 D002259 CTD decreases(expression) XRCC5 D002259 PubChem Potency uM 2.818 ALDH1A1 - GI(Protien) : PubChem Potency uM 5.012 CYP3A4 - GI(Protien) : PubChem Potency uM 10.000 EHMT2 - GI(Protien) : PubChem Potency uM 3.981 MAPT - GI(Protien) : PubChem Potency uM 7.943 MAPT - GI(Protien) : PubChem None uM S1PR1 - GI(Protien) : PubChem None uM STK33 - GI(Protien) : PubChem Potency uM 1.122 TDP1 - GI(Protien) : PubChem Potency uM 1.122 TDP1 - GI(Protien) : PubChem Potency uM 0.631 TSHR - GI(Protien) : PubChem Potency uM 0.891 VDR - GI(Protien) : PubChem Potency uM 1.995 VDR - GI(Protien) : ChEMBL Potency nM 2818.400 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 15848.900 ALOX15B - Target : CHEMBL2457 ChEMBL Potency nM 5011.900 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 10000.000 EHMT2 - Target : CHEMBL6032 ChEMBL Potency nM 7943.300 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 3981.100 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 631.000 TSHR - Target : CHEMBL1963
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