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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

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Collection	D4 : CTD
Chemical Name	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid ( From PubChem : TROLOX )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 250.29 g/mol 2 4 2.4857 True
Structure
InChI	InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/t14-/m0/s1
InChIKey	GLEVLJDDWXEYCO-AWEZNQCLSA-N
Links
Gene (36 / 95) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) ABCA1 C010643 CTD decreases(reaction) ABCA1 C010643 CTD decreases(reaction) ACTA2 C010643 CTD increases(expression) ACTA2 C010643 CTD decreases(reaction) CASP3 C010643 CTD increases(activity) CASP3 C010643 CTD decreases(reaction) CASP3 C010643 CTD increases(activity) CASP3 C010643 CTD decreases(reaction) CASP3 C010643 CTD increases(cleavage) CASP3 C010643 CTD decreases(reaction) CASP6 C010643 CTD increases(activity) CASP6 C010643 CTD decreases(reaction) CASP8 C010643 CTD increases(activity) CASP8 C010643 CTD decreases(reaction) CASP9 C010643 CTD increases(activity) CASP9 C010643 CTD decreases(reaction) CASP9 C010643 CTD increases(activity) CASP9 C010643 CTD affects(localization) CYCS C010643 CTD decreases(reaction) CYCS C010643 CTD decreases(reaction) CYP2E1 C010643 CTD increases(degradation) CYP2E1 C010643 CTD decreases(expression) FLT1 C010643 CTD decreases(reaction) FN1 C010643 CTD increases(expression) FN1 C010643 CTD increases(secretion) FN1 C010643 CTD affects(cotreatment) FOS C010643 CTD decreases(reaction) FOS C010643 CTD increases(expression) FOS C010643 CTD decreases(reaction) HGF C010643 CTD increases(expression) HGF C010643 CTD decreases(reaction) HIF1A C010643 CTD increases(expression) HIF1A C010643 CTD decreases(reaction) HIF1A C010643 CTD increases(expression) HIF1A C010643 CTD decreases(reaction) HSPA5 C010643 CTD increases(expression) HSPA5 C010643 CTD decreases(reaction) IL1A C010643 CTD increases(expression) IL1A C010643 CTD decreases(reaction) IL1B C010643 CTD increases(expression) IL1B C010643 CTD decreases(reaction) IL1B C010643 CTD increases(chemical synthesis) IL1B C010643 CTD increases(reaction) IL1B C010643 CTD decreases(response to substance) IL1B C010643 CTD decreases(abundance) IL2 C010643 CTD decreases(expression) IL2 C010643 CTD decreases(reaction) IL6 C010643 CTD increases(expression) IL6 C010643 CTD decreases(expression) KDR C010643 CTD decreases(reaction) MAP3K5 C010643 CTD increases(phosphorylation) MAP3K5 C010643 CTD decreases(reaction) MAPK1 C010643 CTD increases(phosphorylation) MAPK1 C010643 CTD decreases(reaction) MAPK3 C010643 CTD increases(phosphorylation) MAPK3 C010643 CTD decreases(reaction) MAPK8 C010643 CTD increases(phosphorylation) MAPK8 C010643 CTD decreases(reaction) MAPK9 C010643 CTD increases(phosphorylation) MAPK9 C010643 CTD decreases(reaction) MMP1 C010643 CTD increases(expression) MMP1 C010643 CTD decreases(reaction) MMP13 C010643 CTD increases(expression) MMP13 C010643 CTD decreases(reaction) PGK1 C010643 CTD increases(expression) PGK1 C010643 CTD decreases(reaction) PON2 C010643 CTD increases(expression) PON2 C010643 CTD affects(cotreatment) SLC6A3 C010643 CTD decreases(reaction) SLC6A3 C010643 CTD increases(expression) SLC6A3 C010643 CTD decreases(reaction) SOD1 C010643 CTD increases(activity) SOD1 C010643 CTD decreases(reaction) SOD2 C010643 CTD increases(activity) SOD2 C010643 CTD decreases(abundance) SOD2 C010643 CTD decreases(expression) SOD2 C010643 CTD decreases(reaction) TGFB1 C010643 CTD increases(expression) TGFB1 C010643 CTD decreases(reaction) TNF C010643 CTD increases(expression) TNF C010643 CTD decreases(response to substance) TNF C010643 CTD increases(response to substance) TNF C010643 CTD affects(localization) TNFSF10 C010643 CTD decreases(reaction) TNFSF10 C010643 CTD decreases(reaction) TNFSF10 C010643 CTD increases(abundance) TNFSF10 C010643 CTD increases(activity) TNFSF10 C010643 CTD increases(chemical synthesis) TNFSF10 C010643 CTD decreases(response to substance) TNFSF10 C010643 CTD decreases(reaction) VEGFA C010643 CTD increases(expression) VEGFA C010643 CTD decreases(secretion) VEGFA C010643 PubChem Potency uM 14.125 EHMT2 - GI(Protien) : ChEMBL Potency nM 14125.400 EHMT2 - Target : CHEMBL6032
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