Tan Lab | DSigDB

Gene Set: D4 : CTD - Bumetanide

Collection

D4 : CTD

Chemical Name

Bumetanide ( From PubChem : BUMETANIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
364.416 g/mol	3	7	4.8906	True

Structure

InChI

InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)

InChIKey

Links

Gene (14 / 29)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(transport)			ABCC4		D002034
CTD	decreases(activity)			CFTR		D002034
CTD	decreases(reaction)			F2RL1		D002034
CTD	increases(transport)			F2RL1		D002034
CTD	affects(cotreatment)			REN		D002034
CTD	increases(expression)			REN		D002034
CTD	increases(secretion)			REN		D002034
CTD	decreases(reaction)			REN		D002034
CTD	increases(activity)			REN		D002034
CTD	decreases(reaction)			REN		D002034
CTD	affects(transport)			SLC17A3		D002034
CTD	affects(transport)			SLC22A11		D002034
CTD	decreases(reaction)			SLC22A11		D002034
CTD	decreases(reaction)			SLC22A7		D002034
CTD	increases(transport)			SLC22A7		D002034
CTD	affects(transport)			SLC22A8		D002034
CTD	decreases(reaction)			SLC22A8		D002034
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	Potency	uM	5.805	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	6.513	NFE2L2	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	25118.900	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	5804.800	NFE2L2	-	Target : CHEMBL1075094

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