Tan Lab | DSigDB

Gene Set: D4 : CTD - Berberine

Collection

D4 : CTD

Chemical Name

Berberine ( From PubChem : BERBERINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
336.361 g/mol	0	4	3.0963	True

Structure

InChI

InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

InChIKey

YBHILYKTIRIUTE-UHFFFAOYSA-N

Links

Gene (45 / 87)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			AHR		D001599
CTD	decreases(phosphorylation)			AKT1		D001599
CTD	decreases(reaction)			AKT1		D001599
CTD	increases(phosphorylation)			AKT1		D001599
CTD	increases(expression)			BAX		D001599
CTD	increases(expression)			BAX		D001599
CTD	decreases(expression)			BCL2		D001599
CTD	decreases(reaction)			BCL2		D001599
CTD	decreases(expression)			BCL2		D001599
CTD	decreases(expression)			BCL2		D001599
CTD	increases(expression)			BCL2		D001599
CTD	decreases(expression)			BCL2L1		D001599
CTD	affects(binding)			BIRC5		D001599
CTD	increases(activity)			CASP3		D001599
CTD	increases(activity)			CASP3		D001599
CTD	increases(cleavage)			CASP3		D001599
CTD	increases(expression)			CASP3		D001599
CTD	increases(activity)			CASP8		D001599
CTD	increases(cleavage)			CASP9		D001599
CTD	decreases(reaction)			CCL2		D001599
CTD	increases(expression)			CCL2		D001599
CTD	increases(secretion)			CCL2		D001599
CTD	decreases(expression)			CCND1		D001599
CTD	decreases(expression)			CCND2		D001599
CTD	decreases(expression)			CCNE1		D001599
CTD	decreases(expression)			CDK2		D001599
CTD	decreases(expression)			CDK4		D001599
CTD	decreases(expression)			CDK6		D001599
CTD	increases(expression)			CDKN1A		D001599
CTD	increases(expression)			CDKN1B		D001599
CTD	increases(expression)			CHEK1		D001599
CTD	increases(expression)			CHEK2		D001599
CTD	decreases(reaction)			CXCL8		D001599
CTD	increases(expression)			CXCL8		D001599
CTD	increases(secretion)			CXCL8		D001599
CTD	affects(localization)			CYCS		D001599
CTD	decreases(activity)			CYP1A1		D001599
CTD	increases(expression)			CYP1A1		D001599
CTD	increases(expression)			FAS		D001599
CTD	increases(expression)			FASLG		D001599
CTD	decreases(phosphorylation)			GSK3B		D001599
CTD	decreases(reaction)			GSK3B		D001599
CTD	increases(phosphorylation)			GSK3B		D001599
CTD	increases(expression)			H2AFX		D001599
CTD	affects(reaction)			H2AFX		D001599
CTD	increases(expression)			HMOX1		D001599
CTD	increases(reaction)			HMOX1		D001599
CTD	decreases(reaction)			HMOX1		D001599
CTD	decreases(expression)			IGF1R		D001599
CTD	decreases(reaction)			IGF1R		D001599
CTD	increases(expression)			IGF1R		D001599
CTD	decreases(reaction)			IL1B		D001599
CTD	increases(expression)			IL1B		D001599
CTD	increases(secretion)			IL1B		D001599
CTD	decreases(activity)			MMP2		D001599
CTD	increases(reaction)			MMP2		D001599
CTD	increases(expression)			NFE2L2		D001599
CTD	decreases(reaction)			NFE2L2		D001599
CTD	increases(abundance)			NFE2L2		D001599
CTD	decreases(expression)			NGF		D001599
CTD	decreases(reaction)			NGF		D001599
CTD	increases(expression)			NGF		D001599
CTD	affects(reaction)			P2RX7		D001599
CTD	increases(activity)			P2RX7		D001599
CTD	increases(cleavage)			PARP1		D001599
CTD	decreases(expression)			SI		D001599
CTD	decreases(reaction)			SI		D001599
CTD	decreases(reaction)			TNF		D001599
CTD	increases(expression)			TNF		D001599
CTD	increases(secretion)			TNF		D001599
CTD	increases(expression)			TNF		D001599
CTD	increases(secretion)			TNF		D001599
CTD	decreases(activity)			TOP1		D001599
CTD	affects(reaction)			TOP2A		D001599
CTD	increases(expression)			TOP2A		D001599
CTD	affects(response to substance)			TOP2A		D001599
CTD	increases(expression)			TP53		D001599
CTD	increases(expression)			TRAF1		D001599
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	2.512	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
ChEMBL	AC50	nM	5011.870	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	2511.890	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	2511.900	CYP2D6	-	Target : CHEMBL289

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