Tan Lab | DSigDB

Gene Set: D4 : CTD - Amphotericin B

Collection

D4 : CTD

Chemical Name

Amphotericin B ( From PubChem : AMPHOTERICIN B )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
924.079 g/mol	12	18	1.412	False(1/4)

Structure

InChI

InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38?,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChIKey

APKFDSVGJQXUKY-ZCGADPMASA-N

Links

Gene (39 / 60)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ARHGEF26		D000666
CTD	affects(binding)			ARNT		D000666
CTD	decreases(reaction)			ARNT		D000666
CTD	decreases(expression)			ATG3		D000666
CTD	increases(expression)			EDNRB		D000666
CTD	decreases(reaction)			ENO1		D000666
CTD	increases(expression)			ENO1		D000666
CTD	affects(binding)			EP300		D000666
CTD	decreases(reaction)			EP300		D000666
CTD	increases(reaction)			EP300		D000666
CTD	affects(binding)			EPO		D000666
CTD	decreases(reaction)			EPO		D000666
CTD	increases(expression)			EPO		D000666
CTD	decreases(expression)			EPO		D000666
CTD	decreases(expression)			GLOD4		D000666
CTD	increases(expression)			GPR20		D000666
CTD	decreases(reaction)			GSTP1		D000666
CTD	increases(metabolic processing)			GSTP1		D000666
CTD	affects(binding)			HIF1A		D000666
CTD	decreases(reaction)			HIF1A		D000666
CTD	increases(reaction)			HIF1A		D000666
CTD	decreases(activity)			HIF1A		D000666
CTD	increases(hydroxylation)			HIF1A		D000666
CTD	affects(binding)			HIF1AN		D000666
CTD	decreases(activity)			HIF1AN		D000666
CTD	increases(hydroxylation)			HIF1AN		D000666
CTD	increases(reaction)			HIF1AN		D000666
CTD	increases(expression)			HLA-F		D000666
CTD	affects(cotreatment)			IFNG		D000666
CTD	increases(expression)			IFNG		D000666
CTD	increases(expression)			IFNGR1		D000666
CTD	decreases(expression)			IGFBP5		D000666
CTD	affects(cotreatment)			IL10		D000666
CTD	decreases(expression)			IL10		D000666
CTD	decreases(expression)			KCNQ4		D000666
CTD	decreases(expression)			LSG1		D000666
CTD	decreases(expression)			NPRL2		D000666
CTD	increases(expression)			NT5C2		D000666
CTD	decreases(expression)			PAIP1		D000666
CTD	decreases(expression)			PARD3		D000666
CTD	decreases(reaction)			PGK1		D000666
CTD	increases(expression)			PGK1		D000666
CTD	increases(expression)			POLM		D000666
CTD	decreases(expression)			RUNX3		D000666
CTD	decreases(expression)			SLIT1		D000666
CTD	affects(cotreatment)			TGFB1		D000666
CTD	decreases(expression)			TGFB1		D000666
CTD	increases(expression)			USP36		D000666
CTD	decreases(expression)			ZNF671		D000666
PubChem	Ratio Potency (uM)	uM	61.131	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	54.954	NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.978	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	42.163	TNF	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159

Download gene sets

gmt, text, Detailed text