Tan Lab | DSigDB

Gene Set: D4 : CTD - Alprostadil

Collection

D4 : CTD

Chemical Name

Alprostadil ( From PubChem : ALPROSTADIL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
354.481 g/mol	3	5	3.4751	True

Structure

InChI

InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChIKey

GMVPRGQOIOIIMI-DWKJAMRDSA-N

Links

Gene (16 / 20)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCC4		D000527
CTD	increases(hydrolysis)			ABCC4		D000527
CTD	increases(reaction)			ABCC4		D000527
CTD	increases(phosphorylation)			ADRB2		D000527
CTD	increases(expression)			AGT		D000527
CTD	decreases(expression)			NPPA		D000527
CTD	decreases(expression)			NPPB		D000527
CTD	increases(expression)			REN		D000527
CTD	decreases(reaction)			TNF		D000527
CTD	increases(expression)			TNF		D000527
CTD	increases(phosphorylation)			VASP		D000527
PubChem	AR Potency (uM)	uM	0.024	AR	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

Download gene sets

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