Tan Lab | DSigDB

Gene Set: D4 : CTD - Alprazolam

Collection

D4 : CTD

Chemical Name

Alprazolam ( From PubChem : ALPRAZOLAM )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	4

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
308.765 g/mol	0	4	3.0157	True

Structure

InChI

InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

InChIKey

Links

Gene (19 / 35)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			CAPN1		D000525
CTD	increases(activity)			CAPN1		D000525
CTD	increases(reaction)			CAPN1		D000525
CTD	affects(cotreatment)			CASP3		D000525
CTD	increases(cleavage)			CASP3		D000525
CTD	affects(cotreatment)			CTSB		D000525
CTD	increases(secretion)			CTSB		D000525
CTD	affects(metabolic processing)			CYP3A4		D000525
CTD	affects(binding)			CYP3A4		D000525
CTD	affects(metabolic processing)			CYP3A4		D000525
CTD	increases(hydroxylation)			CYP3A5		D000525
CTD	increases(secretion)			LHB		D000525
CTD	affects(cotreatment)			PARP1		D000525
CTD	increases(activity)			PARP1		D000525
CTD	increases(hydroxylation)			PPIA		D000525
CTD	decreases(reaction)			SLC22A2		D000525
CTD	increases(uptake)			SLC22A2		D000525
PubChem	Ratio Potency (uM)	uM	4.253	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	6.007	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	10.192	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.883	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.314	ESR1	-	GI(Protien) :
PubChem	Potency	uM	15.849	HPGD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.007	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
ChEMBL	Activity	-		BRD2	-	Target : CHEMBL1293289
ChEMBL	Activity	-		BRD2	-	Target : CHEMBL1293289
ChEMBL	Activity	-		BRD3	-	Target : CHEMBL1795186
ChEMBL	Activity	-		BRD3	-	Target : CHEMBL1795186
ChEMBL	Activity	-		BRD4	-	Target : CHEMBL1163125
ChEMBL	Activity	-		BRD4	-	Target : CHEMBL1163125
ChEMBL	Activity	-		BRDT	-	Target : CHEMBL1795185
ChEMBL	Activity	-		CREBBP	-	Target : CHEMBL5747
ChEMBL	Potency	nM	15848.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Activity	-		PBRM1	-	Target : CHEMBL1795184

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