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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - Adenosine Triphosphate

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Collection	D4 : CTD
Chemical Name	Adenosine Triphosphate ( From PubChem : ADENOSINE TRIPHOSPHATE )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Approved Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 507.181 g/mol 7 18 -1.0478 False(1/4)
Structure
InChI	InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey	ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Links
Gene (84 / 231) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD affects(reaction) ABCA8 D000255 CTD increases(uptake) ABCA8 D000255 CTD affects(binding) ABCB1 D000255 CTD increases(hydrolysis) ABCB1 D000255 CTD increases(hydrolysis) ABCB1 D000255 CTD increases(reaction) ABCB1 D000255 CTD affects(reaction) ABCB1 D000255 CTD increases(reaction) ABCB11 D000255 CTD increases(uptake) ABCB11 D000255 CTD affects(binding) ABCC1 D000255 CTD increases(degradation) ABCC1 D000255 CTD affects(binding) ABCC1 D000255 CTD increases(hydrolysis) ABCC1 D000255 CTD increases(hydrolysis) ABCC1 D000255 CTD affects(binding) ABCC1 D000255 CTD affects(binding) ABCC1 D000255 CTD affects(folding) ABCC1 D000255 CTD affects(transport) ABCC1 D000255 CTD increases(reaction) ABCC1 D000255 CTD affects(transport) ABCC1 D000255 CTD increases(reaction) ABCC1 D000255 CTD affects(transport) ABCC1 D000255 CTD increases(reaction) ABCC1 D000255 CTD increases(reaction) ABCC1 D000255 CTD affects(reaction) ABCC1 D000255 CTD affects(reaction) ABCC1 D000255 CTD decreases(reaction) ABCC1 D000255 CTD affects(metabolic processing) ABCC2 D000255 CTD affects(binding) ABCC4 D000255 CTD increases(hydrolysis) ABCC4 D000255 CTD increases(hydrolysis) ABCC4 D000255 CTD increases(reaction) ABCC4 D000255 CTD decreases(reaction) ABCC4 D000255 CTD affects(reaction) ABCC4 D000255 CTD decreases(reaction) ABCC4 D000255 CTD affects(binding) ABCC6 D000255 CTD affects(cotreatment) ABL1 D000255 CTD increases(phosphorylation) ABL1 D000255 CTD decreases(reaction) ABL1 D000255 CTD affects(binding) ALK D000255 CTD increases(reaction) ALK D000255 CTD decreases(response to substance) ALK D000255 CTD affects(cotreatment) ATP7A D000255 CTD increases(phosphorylation) ATP7A D000255 CTD increases(phosphorylation) ATP7B D000255 CTD affects(cotreatment) ATP7B D000255 CTD increases(phosphorylation) ATP7B D000255 CTD affects(binding) BCL2 D000255 CTD decreases(expression) BCL2 D000255 CTD affects(cotreatment) BCR D000255 CTD increases(phosphorylation) BCR D000255 CTD decreases(reaction) BCR D000255 CTD affects(cotreatment) CASP1 D000255 CTD increases(cleavage) CASP1 D000255 CTD increases(expression) CASP3 D000255 CTD decreases(reaction) CASP3 D000255 CTD increases(expression) CAT D000255 CTD decreases(reaction) CFTR D000255 CTD increases(export) CFTR D000255 CTD increases(reaction) CFTR D000255 CTD affects(reaction) CFTR D000255 CTD increases(activity) CFTR D000255 CTD affects(binding) CFTR D000255 CTD increases(activity) CFTR D000255 CTD affects(cotreatment) CFTR D000255 CTD increases(activity) CFTR D000255 CTD affects(binding) CHORDC1 D000255 CTD increases(reaction) CHORDC1 D000255 CTD decreases(abundance) COMT D000255 CTD decreases(activity) COMT D000255 CTD increases(abundance) COX3 D000255 CTD increases(abundance) CPT2 D000255 CTD increases(activity) CPT2 D000255 CTD increases(reaction) CPT2 D000255 CTD affects(cotreatment) CRKL D000255 CTD increases(phosphorylation) CRKL D000255 CTD decreases(reaction) CRKL D000255 CTD decreases(activity) ENPP7 D000255 CTD affects(reaction) F2 D000255 CTD increases(secretion) F2 D000255 CTD increases(abundance) F2 D000255 CTD decreases(reaction) F2 D000255 CTD affects(cotreatment) GAPDH D000255 CTD decreases(reaction) GAPDH D000255 CTD increases(reduction) GAPDH D000255 CTD increases(secretion) GH1 D000255 CTD decreases(reaction) GH1 D000255 CTD affects(reaction) GH1 D000255 CTD increases(export) GJA1 D000255 CTD affects(cotreatment) GSTP1 D000255 CTD decreases(reaction) GSTP1 D000255 CTD increases(activity) GSTP1 D000255 CTD increases(abundance) GSTP1 D000255 CTD increases(metabolic processing) GSTP1 D000255 CTD decreases(activity) HIF1A D000255 CTD decreases(reaction) HIF1A D000255 CTD decreases(reaction) ICAM1 D000255 CTD increases(expression) ICAM1 D000255 CTD decreases(reaction) IL12B D000255 CTD increases(expression) IL12B D000255 CTD affects(cotreatment) IL18 D000255 CTD increases(secretion) IL18 D000255 CTD affects(cotreatment) IL1B D000255 CTD increases(secretion) IL1B D000255 CTD affects(cotreatment) IL1B D000255 CTD increases(cleavage) IL1B D000255 CTD increases(secretion) IL1B D000255 CTD decreases(reaction) IL6 D000255 CTD increases(expression) IL6 D000255 CTD increases(expression) IL6 D000255 CTD decreases(reaction) IL6 D000255 CTD increases(activity) INS D000255 CTD increases(secretion) INS D000255 CTD decreases(reaction) INS D000255 CTD affects(binding) ITGB1BP2 D000255 CTD increases(reaction) ITGB1BP2 D000255 CTD increases(activity) KCNJ15 D000255 CTD decreases(abundance) KHK D000255 CTD increases(reaction) KHK D000255 CTD decreases(reaction) KIF5A D000255 CTD increases(hydrolysis) KIF5A D000255 CTD increases(activity) LIPE D000255 CTD affects(response to substance) LPL D000255 CTD decreases(reaction) MAPK1 D000255 CTD increases(phosphorylation) MAPK1 D000255 CTD increases(phosphorylation) MAPK1 D000255 CTD decreases(reaction) MAPK3 D000255 CTD increases(phosphorylation) MAPK3 D000255 CTD increases(phosphorylation) MAPK3 D000255 CTD affects(cotreatment) NADSYN1 D000255 CTD increases(activity) NADSYN1 D000255 CTD increases(chemical synthesis) NADSYN1 D000255 CTD affects(cotreatment) NLRP3 D000255 CTD increases(activity) NLRP3 D000255 CTD affects(binding) NOLC1 D000255 CTD affects(reaction) NOLC1 D000255 CTD affects(reaction) NOS2 D000255 CTD increases(metabolic processing) NOS2 D000255 CTD affects(response to substance) NPY D000255 CTD increases(chemical synthesis) OAS1 D000255 CTD increases(metabolic processing) OAS1 D000255 CTD increases(activity) P2RX7 D000255 CTD affects(reaction) P2RX7 D000255 CTD increases(secretion) P2RX7 D000255 CTD increases(transport) P2RX7 D000255 CTD affects(binding) P2RY1 D000255 CTD increases(activity) P2RY1 D000255 CTD increases(abundance) P2RY1 D000255 CTD decreases(reaction) P2RY1 D000255 CTD decreases(response to substance) P2RY1 D000255 CTD increases(reaction) P2RY1 D000255 CTD decreases(reaction) P2RY1 D000255 CTD affects(binding) P2RY11 D000255 CTD decreases(expression) P2RY11 D000255 CTD increases(response to substance) P2RY11 D000255 CTD decreases(reaction) P2RY13 D000255 CTD decreases(response to substance) P2RY13 D000255 CTD increases(reaction) P2RY13 D000255 CTD increases(activity) P2RY2 D000255 CTD increases(abundance) P2RY2 D000255 CTD affects(binding) P2RY4 D000255 CTD increases(activity) P2RY4 D000255 CTD increases(abundance) P2RY4 D000255 CTD decreases(reaction) P2RY4 D000255 CTD decreases(reaction) P2RY6 D000255 CTD decreases(response to substance) P2RY6 D000255 CTD increases(reaction) P2RY6 D000255 CTD decreases(activity) PANX1 D000255 CTD decreases(reaction) PANX1 D000255 CTD increases(export) PANX1 D000255 CTD decreases(abundance) PARP1 D000255 CTD decreases(reaction) PARP1 D000255 CTD affects(binding) PIK3CA D000255 CTD decreases(reaction) PIK3CA D000255 CTD affects(binding) PIK3CA D000255 CTD decreases(activity) PIK3CA D000255 CTD decreases(reaction) PIK3CA D000255 CTD affects(binding) PIK3R1 D000255 CTD decreases(activity) PIK3R1 D000255 CTD decreases(reaction) PIK3R1 D000255 CTD affects(binding) PPP5C D000255 CTD affects(folding) PPP5C D000255 CTD increases(reaction) PPP5C D000255 CTD affects(cotreatment) PRKCA D000255 CTD increases(phosphorylation) PRKCA D000255 CTD increases(transport) PRKCA D000255 CTD affects(cotreatment) RALBP1 D000255 CTD increases(phosphorylation) RALBP1 D000255 CTD increases(transport) RALBP1 D000255 CTD affects(transport) RALBP1 D000255 CTD increases(reaction) RALBP1 D000255 CTD affects(reaction) RELA D000255 CTD increases(metabolic processing) RELA D000255 CTD increases(reaction) RELA D000255 CTD affects(reaction) SELL D000255 CTD increases(secretion) SELL D000255 CTD affects(binding) SFTPA1 D000255 CTD decreases(reaction) SFTPA1 D000255 CTD increases(secretion) SFTPA1 D000255 CTD affects(binding) SFTPA2 D000255 CTD decreases(reaction) SFTPA2 D000255 CTD increases(secretion) SFTPA2 D000255 CTD decreases(chemical synthesis) SLC25A14 D000255 CTD decreases(stability) SLC2A1 D000255 CTD decreases(chemical synthesis) SLC46A1 D000255 CTD increases(response to substance) SLC46A1 D000255 CTD decreases(reaction) SLC5A5 D000255 CTD increases(expression) SLC5A5 D000255 CTD increases(expression) SOD1 D000255 CTD affects(binding) SUGT1 D000255 CTD increases(reaction) SUGT1 D000255 CTD decreases(expression) TIMM17A D000255 CTD decreases(reaction) TIMM17A D000255 CTD decreases(reaction) TNF D000255 CTD increases(expression) TNF D000255 CTD decreases(reaction) TOP2A D000255 CTD increases(hydrolysis) TOP2A D000255 CTD decreases(abundance) TP53 D000255 CTD decreases(reaction) TP53 D000255 CTD decreases(reaction) TSHB D000255 CTD increases(expression) TSHB D000255 CTD increases(expression) TXN D000255 CTD decreases(reaction) UCP2 D000255 CTD increases(transport) UCP2 D000255 CTD decreases(reaction) UCP3 D000255 CTD increases(transport) UCP3 D000255 CTD decreases(abundance) VDAC1 D000255 CTD decreases(reaction) VDAC1 D000255 ChEMBL Activity - ABL1 - Target : CHEMBL1862 ChEMBL IC50 nM 3370.000 HSPA1A; HSPA1B - Target : CHEMBL5460 ChEMBL IC50 nM 17300.000 HSPA8 - Target : CHEMBL1275223
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