Tan Lab | DSigDB

Gene Set: D4 : CTD - Acrolein

Collection

D4 : CTD

Chemical Name

Acrolein ( From PubChem : ACROLEIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
56.0633 g/mol	0	1	0.3713	True

Structure

InChI

InChI=1S/C3H4O/c1-2-3-4/h2-3H,1H2

InChIKey

HGINCPLSRVDWNT-UHFFFAOYSA-N

Links

Gene (139 / 319)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ADAM17		D000171
CTD	increases(reaction)			ADAM17		D000171
CTD	affects(localization)			AIFM1		D000171
CTD	increases(reduction)			AKR1A1		D000171
CTD	affects(reduction)			AKR1B1		D000171
CTD	increases(reduction)			AKR1B1		D000171
CTD	increases(reduction)			AKR1B1		D000171
CTD	affects(metabolic processing)			AKR1B10		D000171
CTD	affects(metabolic processing)			AKR1B10		D000171
CTD	decreases(response to substance)			AKR1B10		D000171
CTD	increases(reduction)			AKR1B10		D000171
CTD	increases(expression)			AKT1		D000171
CTD	increases(phosphorylation)			AKT1		D000171
CTD	affects(binding)			ALB		D000171
CTD	affects(binding)			ALDH1A1		D000171
CTD	decreases(activity)			ALDH1A1		D000171
CTD	increases(oxidation)			ALDH1A1		D000171
CTD	affects(cotreatment)			ALDH1A1		D000171
CTD	decreases(reaction)			ALDH1A1		D000171
CTD	affects(binding)			ALDH2		D000171
CTD	decreases(activity)			ALDH2		D000171
CTD	increases(oxidation)			ALDH2		D000171
CTD	decreases(reaction)			ALDH2		D000171
CTD	increases(expression)			AMPD3		D000171
CTD	affects(metabolic processing)			APOA1		D000171
CTD	affects(metabolic processing)			APOA1		D000171
CTD	decreases(secretion)			APOA1		D000171
CTD	affects(transport)			APOA1		D000171
CTD	decreases(reaction)			APOA1		D000171
CTD	affects(folding)			APOE		D000171
CTD	decreases(activity)			APOE		D000171
CTD	affects(binding)			APP		D000171
CTD	increases(reaction)			APP		D000171
CTD	affects(localization)			ATF3		D000171
CTD	increases(expression)			ATF3		D000171
CTD	decreases(reaction)			ATF3		D000171
CTD	affects(localization)			ATF4		D000171
CTD	increases(expression)			ATF4		D000171
CTD	decreases(reaction)			BAD		D000171
CTD	increases(phosphorylation)			BAD		D000171
CTD	affects(localization)			BAX		D000171
CTD	decreases(reaction)			BIRC2		D000171
CTD	increases(expression)			BIRC2		D000171
CTD	decreases(reaction)			BIRC3		D000171
CTD	increases(expression)			BIRC3		D000171
CTD	affects(alkylation)			CASP3		D000171
CTD	decreases(activity)			CASP3		D000171
CTD	increases(activity)			CASP3		D000171
CTD	increases(activity)			CASP6		D000171
CTD	increases(activity)			CASP7		D000171
CTD	affects(activity)			CASP8		D000171
CTD	affects(alkylation)			CASP8		D000171
CTD	affects(cleavage)			CASP8		D000171
CTD	decreases(reaction)			CASP8		D000171
CTD	increases(activity)			CASP8		D000171
CTD	increases(cleavage)			CASP8		D000171
CTD	increases(activity)			CASP9		D000171
CTD	decreases(expression)			CDC34		D000171
CTD	decreases(reaction)			CLDN5		D000171
CTD	increases(expression)			CLDN5		D000171
CTD	decreases(expression)			CLDN5		D000171
CTD	increases(phosphorylation)			CREB1		D000171
CTD	decreases(secretion)			CSF2		D000171
CTD	increases(expression)			CTNNB1		D000171
CTD	affects(cotreatment)			CXCL8		D000171
CTD	increases(expression)			CXCL8		D000171
CTD	decreases(reaction)			CXCL8		D000171
CTD	increases(expression)			CXCL8		D000171
CTD	decreases(expression)			CXCL8		D000171
CTD	increases(expression)			CXCL8		D000171
CTD	increases(secretion)			CXCL8		D000171
CTD	decreases(reaction)			CXCL8		D000171
CTD	decreases(reaction)			CXCL8		D000171
CTD	affects(localization)			CYCS		D000171
CTD	affects(localization)			DDIT3		D000171
CTD	increases(expression)			DDIT3		D000171
CTD	increases(expression)			DDIT3		D000171
CTD	decreases(expression)			DEFB4A		D000171
CTD	increases(expression)			EDN1		D000171
CTD	decreases(reaction)			EDN1		D000171
CTD	increases(activity)			EGFR		D000171
CTD	increases(phosphorylation)			EGFR		D000171
CTD	affects(reaction)			EGFR		D000171
CTD	increases(expression)			EGFR		D000171
CTD	decreases(reaction)			EGFR		D000171
CTD	increases(phosphorylation)			EGFR		D000171
CTD	increases(expression)			EGR1		D000171
CTD	increases(phosphorylation)			EIF2S1		D000171
CTD	affects(expression)			EMD		D000171
CTD	affects(expression)			ESR1		D000171
CTD	decreases(reaction)			FAS		D000171
CTD	increases(activity)			FAS		D000171
CTD	increases(cleavage)			FAS		D000171
CTD	increases(phosphorylation)			FOXO1		D000171
CTD	increases(expression)			FTH1		D000171
CTD	increases(expression)			FTL		D000171
CTD	increases(expression)			GADD45B		D000171
CTD	affects(expression)			GAL3ST1		D000171
CTD	affects(binding)			GAPDH		D000171
CTD	decreases(activity)			GAPDH		D000171
CTD	increases(expression)			GCLC		D000171
CTD	increases(expression)			GCLM		D000171
CTD	affects(binding)			GSTP1		D000171
CTD	decreases(activity)			GSTP1		D000171
CTD	increases(metabolic processing)			GSTP1		D000171
CTD	increases(expression)			HERPUD1		D000171
CTD	decreases(reaction)			HMOX1		D000171
CTD	increases(expression)			HMOX1		D000171
CTD	increases(expression)			HMOX1		D000171
CTD	increases(expression)			HMOX1		D000171
CTD	increases(reaction)			HMOX1		D000171
CTD	increases(expression)			HSPA5		D000171
CTD	decreases(secretion)			IFNG		D000171
CTD	affects(metabolic processing)			IKBKB		D000171
CTD	decreases(secretion)			IL10		D000171
CTD	affects(binding)			IL2		D000171
CTD	decreases(reaction)			IL2		D000171
CTD	decreases(secretion)			IL2		D000171
CTD	affects(cotreatment)			IL6		D000171
CTD	increases(expression)			IL6		D000171
CTD	decreases(reaction)			IL6		D000171
CTD	increases(expression)			IL6		D000171
CTD	decreases(expression)			ITGB3		D000171
CTD	affects(metabolic processing)			JUN		D000171
CTD	affects(binding)			JUN		D000171
CTD	decreases(activity)			JUN		D000171
CTD	increases(phosphorylation)			JUN		D000171
CTD	decreases(reaction)			JUN		D000171
CTD	increases(phosphorylation)			JUN		D000171
CTD	increases(expression)			KCNA5		D000171
CTD	decreases(reaction)			KCNA5		D000171
CTD	decreases(reaction)			KEAP1		D000171
CTD	decreases(response to substance)			KEAP1		D000171
CTD	increases(activity)			KEAP1		D000171
CTD	decreases(expression)			KRAS		D000171
CTD	increases(metabolic processing)			KRT18		D000171
CTD	increases(metabolic processing)			KRT7		D000171
CTD	increases(metabolic processing)			KRT8		D000171
CTD	increases(phosphorylation)			KRT8		D000171
CTD	decreases(reaction)			MAPK1		D000171
CTD	increases(phosphorylation)			MAPK1		D000171
CTD	increases(phosphorylation)			MAPK1		D000171
CTD	decreases(reaction)			MAPK1		D000171
CTD	increases(phosphorylation)			MAPK1		D000171
CTD	increases(phosphorylation)			MAPK14		D000171
CTD	decreases(reaction)			MAPK14		D000171
CTD	increases(phosphorylation)			MAPK14		D000171
CTD	decreases(reaction)			MAPK3		D000171
CTD	increases(phosphorylation)			MAPK3		D000171
CTD	increases(phosphorylation)			MAPK3		D000171
CTD	decreases(reaction)			MAPK3		D000171
CTD	increases(phosphorylation)			MAPK3		D000171
CTD	increases(phosphorylation)			MAPK8		D000171
CTD	decreases(reaction)			MAPK8		D000171
CTD	increases(phosphorylation)			MAPK8		D000171
CTD	decreases(reaction)			MAPK8		D000171
CTD	increases(phosphorylation)			MAPK8		D000171
CTD	increases(phosphorylation)			MAPT		D000171
CTD	decreases(reaction)			MAPT		D000171
CTD	decreases(response to substance)			MGMT		D000171
CTD	decreases(expression)			MIR188		D000171
CTD	increases(expression)			MIR191		D000171
CTD	decreases(expression)			MIR198		D000171
CTD	increases(expression)			MIR218-1		D000171
CTD	increases(expression)			MIR223		D000171
CTD	increases(expression)			MIR224		D000171
CTD	decreases(expression)			MIR296		D000171
CTD	increases(expression)			MIR301A		D000171
CTD	decreases(expression)			MIR370		D000171
CTD	decreases(expression)			MIR373		D000171
CTD	decreases(expression)			MIR452		D000171
CTD	decreases(expression)			MIR601		D000171
CTD	decreases(expression)			MIR622		D000171
CTD	decreases(expression)			MIR623		D000171
CTD	increases(expression)			MIR629		D000171
CTD	increases(expression)			MIR636		D000171
CTD	decreases(expression)			MIR638		D000171
CTD	decreases(expression)			MIR663A		D000171
CTD	decreases(expression)			MIR671		D000171
CTD	decreases(expression)			MIR765		D000171
CTD	increases(expression)			MIR98		D000171
CTD	increases(expression)			MIRLET7D		D000171
CTD	increases(expression)			MIRLET7E		D000171
CTD	increases(expression)			MMP1		D000171
CTD	increases(secretion)			MMP1		D000171
CTD	decreases(reaction)			MMP14		D000171
CTD	increases(expression)			MMP14		D000171
CTD	affects(binding)			MMP14		D000171
CTD	increases(activity)			MMP14		D000171
CTD	affects(reaction)			MMP14		D000171
CTD	increases(secretion)			MMP2		D000171
CTD	decreases(reaction)			MMP9		D000171
CTD	increases(expression)			MMP9		D000171
CTD	decreases(reaction)			MMP9		D000171
CTD	increases(expression)			MMP9		D000171
CTD	increases(activity)			MMP9		D000171
CTD	increases(cleavage)			MMP9		D000171
CTD	increases(secretion)			MMP9		D000171
CTD	increases(expression)			MMP9		D000171
CTD	increases(expression)			MMP9		D000171
CTD	increases(secretion)			MMP9		D000171
CTD	increases(reaction)			MMP9		D000171
CTD	decreases(reaction)			MUC5AC		D000171
CTD	increases(expression)			MUC5AC		D000171
CTD	increases(expression)			MUC5AC		D000171
CTD	increases(expression)			MUC5AC		D000171
CTD	increases(reaction)			MUC5AC		D000171
CTD	affects(reaction)			MUC5AC		D000171
CTD	decreases(reaction)			MUC5AC		D000171
CTD	affects(reaction)			MUC5AC		D000171
CTD	increases(expression)			MUC5AC		D000171
CTD	increases(expression)			MYC		D000171
CTD	affects(metabolic processing)			NCF1		D000171
CTD	affects(localization)			NCF1		D000171
CTD	decreases(reaction)			NCF1		D000171
CTD	affects(localization)			NCF2		D000171
CTD	decreases(reaction)			NCF2		D000171
CTD	decreases(expression)			NFE2L1		D000171
CTD	decreases(reaction)			NFE2L1		D000171
CTD	affects(localization)			NFE2L2		D000171
CTD	decreases(expression)			NFE2L2		D000171
CTD	increases(activity)			NFE2L2		D000171
CTD	decreases(reaction)			NFE2L2		D000171
CTD	decreases(response to substance)			NFE2L2		D000171
CTD	increases(activity)			NFE2L2		D000171
CTD	decreases(expression)			NFE2L2		D000171
CTD	decreases(reaction)			NFE2L2		D000171
CTD	increases(response to substance)			NFE2L2		D000171
CTD	affects(reaction)			NFE2L2		D000171
CTD	decreases(response to substance)			NFE2L2		D000171
CTD	increases(expression)			NFE2L2		D000171
CTD	increases(reaction)			NFE2L2		D000171
CTD	affects(localization)			NFE2L2		D000171
CTD	decreases(reaction)			NFE2L2		D000171
CTD	decreases(reaction)			NFE2L2		D000171
CTD	affects(binding)			NFKB1		D000171
CTD	decreases(reaction)			NFKB1		D000171
CTD	decreases(reaction)			NFKB1		D000171
CTD	increases(activity)			NFKB1		D000171
CTD	decreases(activity)			NFKB1		D000171
CTD	decreases(activity)			NFKB1		D000171
CTD	increases(alkylation)			NFKB1		D000171
CTD	increases(expression)			NFKBIA		D000171
CTD	increases(reaction)			NFKBIA		D000171
CTD	affects(expression)			NPR3		D000171
CTD	increases(expression)			NQO1		D000171
CTD	increases(expression)			NQO1		D000171
CTD	increases(expression)			NR4A1		D000171
CTD	increases(cleavage)			PARP1		D000171
CTD	affects(binding)			PON1		D000171
CTD	increases(metabolic processing)			PON1		D000171
CTD	increases(chemical synthesis)			PON1		D000171
CTD	affects(binding)			PON2		D000171
CTD	increases(metabolic processing)			PON2		D000171
CTD	increases(chemical synthesis)			PON2		D000171
CTD	increases(oxidation)			PRDX1		D000171
CTD	increases(oxidation)			PRDX3		D000171
CTD	affects(localization)			PRKCD		D000171
CTD	increases(reaction)			PRKCD		D000171
CTD	decreases(expression)			PTGIS		D000171
CTD	increases(expression)			PTGS2		D000171
CTD	decreases(reaction)			PTGS2		D000171
CTD	decreases(activity)			PTPN1		D000171
CTD	decreases(reaction)			PTPN1		D000171
CTD	affects(localization)			RELA		D000171
CTD	increases(activity)			RELA		D000171
CTD	decreases(reaction)			RELA		D000171
CTD	decreases(expression)			RPS6KB1		D000171
CTD	increases(expression)			SEL1L3		D000171
CTD	increases(expression)			SLC7A11		D000171
CTD	increases(abundance)			SMOX		D000171
CTD	increases(response to substance)			SMOX		D000171
CTD	affects(metabolic processing)			SNCA		D000171
CTD	affects(binding)			SNCA		D000171
CTD	increases(expression)			SQSTM1		D000171
CTD	decreases(expression)			SYNE2		D000171
CTD	decreases(expression)			TFAM		D000171
CTD	decreases(reaction)			TFAM		D000171
CTD	decreases(expression)			TIMP3		D000171
CTD	decreases(reaction)			TIMP3		D000171
CTD	increases(expression)			TIMP3		D000171
CTD	decreases(reaction)			TNF		D000171
CTD	increases(activity)			TNF		D000171
CTD	increases(expression)			TNF		D000171
CTD	increases(reaction)			TNF		D000171
CTD	decreases(secretion)			TNF		D000171
CTD	increases(expression)			TNF		D000171
CTD	decreases(reaction)			TNF		D000171
CTD	decreases(expression)			TNNT2		D000171
CTD	affects(metabolic processing)			TP53		D000171
CTD	affects(binding)			TP53		D000171
CTD	decreases(reaction)			TP53		D000171
CTD	increases(activity)			TP53		D000171
CTD	decreases(activity)			TP53		D000171
CTD	increases(mutagenesis)			TP53		D000171
CTD	increases(expression)			TRIM16L		D000171
CTD	increases(activity)			TRPA1		D000171
CTD	affects(reaction)			TRPA1		D000171
CTD	increases(secretion)			TRPA1		D000171
CTD	increases(uptake)			TRPA1		D000171
CTD	affects(response to substance)			TRPA1		D000171
CTD	decreases(reaction)			TXN		D000171
CTD	increases(oxidation)			TXN		D000171
CTD	affects(metabolic processing)			TXN		D000171
CTD	decreases(activity)			TXN		D000171
CTD	increases(oxidation)			TXN		D000171
CTD	increases(oxidation)			TXN2		D000171
CTD	decreases(reaction)			TXNRD1		D000171
CTD	increases(expression)			TXNRD1		D000171
CTD	decreases(activity)			TXNRD1		D000171
CTD	increases(expression)			TXNRD1		D000171
CTD	increases(expression)			VEGFA		D000171
CTD	decreases(reaction)			VEGFA		D000171
CTD	increases(metabolic processing)			VIM		D000171
CTD	affects(splicing)			XBP1		D000171
PubChem	Potency	uM	0.022	ALDH1A1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	24.882	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	47.308	NFE2L2	-	GI(Protien) :
ChEMBL	Potency	nM	22.400	ALDH1A1	-	Target : CHEMBL3577

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